Enhanced multivalent vaccine responses using a novel vaccine vector system. Enhanced multivalent vaccine responses using a novel vaccine vector system. This project aims to develop a multicomponent vaccine system to deliver equal effectiveness against several disease targets in a single administration. New and innovative vaccine design strategies incorporating economical commercial production processes are urgently needed for new and existing human and animal health applications. A vaccine capab ....Enhanced multivalent vaccine responses using a novel vaccine vector system. Enhanced multivalent vaccine responses using a novel vaccine vector system. This project aims to develop a multicomponent vaccine system to deliver equal effectiveness against several disease targets in a single administration. New and innovative vaccine design strategies incorporating economical commercial production processes are urgently needed for new and existing human and animal health applications. A vaccine capable of targeting multiple diseases by a single injection is an obvious way to expedite future vaccine development and deployment. However, the recipient’s immune system can repress equivalent responses to these multicomponent vaccines. This project’s research is expected to address these problems, and underpin the future commercial development of this vaccine platform.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100016
Funder
Australian Research Council
Funding Amount
$3,123,492.00
Summary
ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therap ....ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therapeutics. The use of an individual patient’s cellular and molecular research findings will ultimately enable personalised diagnostic and therapeutic decisions.Read moreRead less
Exploring the immunomodulatory potential of Natural Killer T cells. Natural Killer T cells (NKT cells) are an innate-like population of T cells that recognise a range of lipid based antigens when bound to the antigen-presenting molecule, CD1d. Once activated, NKT cells rapidly secrete a variety of cytokines. This project, in partnership with Vaxine Pty Ltd, aims to gain a basic understanding of NKT recognition of lipids and NKT cell activation by lipids. The project aims to use a combination of ....Exploring the immunomodulatory potential of Natural Killer T cells. Natural Killer T cells (NKT cells) are an innate-like population of T cells that recognise a range of lipid based antigens when bound to the antigen-presenting molecule, CD1d. Once activated, NKT cells rapidly secrete a variety of cytokines. This project, in partnership with Vaxine Pty Ltd, aims to gain a basic understanding of NKT recognition of lipids and NKT cell activation by lipids. The project aims to use a combination of cellular immunology and structural biology to gain insight into NKT cell agonism.Read moreRead less
The development of a potent new passive immunotherapeutic for the treatment and prevention of bacterial sepsis and septic shock. Bacterial sepsis and septic shock is a leading cause of death in hospital intensive care units and represents a significant public health burden. By developing a new passive immunotherapeutic regimen to treat and prevent bacterial sepsis and septic shock, the project aims to reverse the significant mortality and morbidity associated with this condition.
Testing co-evolutionary processes driving venom diversity in tiger snakes. Testing co-evolutionary processes driving venom diversity in tiger snakes. This project aims to examine the geographic variation amongst tiger snakes in anatomy, ecology, and life history traits, and the relationship of these factors to venom toxins and production; and to evaluate the true pharmacological potential of tiger snake venom. This project will investigate the role of venom adaptation in long-term animal evoluti ....Testing co-evolutionary processes driving venom diversity in tiger snakes. Testing co-evolutionary processes driving venom diversity in tiger snakes. This project aims to examine the geographic variation amongst tiger snakes in anatomy, ecology, and life history traits, and the relationship of these factors to venom toxins and production; and to evaluate the true pharmacological potential of tiger snake venom. This project will investigate the role of venom adaptation in long-term animal evolution, by identifying rare venom transcripts involved in providing evolutionary potential for adaptation to environmental change. This is essential as continuing climatic and human-induced alteration of our environment affects southern Australia where many people live, work and interact with native wildlife. Anticipated outcomes are maximizing venom harvests and enhanced snakebite treatment capacity.Read moreRead less
Development of a vaccine to protect koalas against koala retrovirus (KoRV). This project aims to develop a vaccine against koala retrovirus (KoRV) to arrest the increasing loss of animals due to this infection. Along with Chlamydia, KoRV threatens the long-term survival of the koala. KoRV infects over 95 per cent of Australia’s koalas and has been strongly linked to lymphoma and leukemia. Although quarantine and antiretroviral drug treatment are possible control measures, they are impractical in ....Development of a vaccine to protect koalas against koala retrovirus (KoRV). This project aims to develop a vaccine against koala retrovirus (KoRV) to arrest the increasing loss of animals due to this infection. Along with Chlamydia, KoRV threatens the long-term survival of the koala. KoRV infects over 95 per cent of Australia’s koalas and has been strongly linked to lymphoma and leukemia. Although quarantine and antiretroviral drug treatment are possible control measures, they are impractical in the wild, leaving vaccination as the only realistic option. This is valuable for both wild and captive koalas; zoos report high animal losses due to KoRV-associated lymphoma. The main outcome will be a KoRV vaccine which can be combined with a Chlamydia vaccine which is being developed in parallel.Read moreRead less
Pair bonding: is it all in the brain? This project aims to understand the interaction between classic pair bonding neural circuits, parasites, and the immune system in sleepy lizards. Social bonds are a cornerstone of human societies, especially true of the pair bond and this project expects to generate knowledge to help understand why healthy adult pair bonds are the single best predictor of longevity in humans. The expected outcomes of this project are to reveal the mechanistic basis of pair b ....Pair bonding: is it all in the brain? This project aims to understand the interaction between classic pair bonding neural circuits, parasites, and the immune system in sleepy lizards. Social bonds are a cornerstone of human societies, especially true of the pair bond and this project expects to generate knowledge to help understand why healthy adult pair bonds are the single best predictor of longevity in humans. The expected outcomes of this project are to reveal the mechanistic basis of pair bonding by identifying the brain regions, cell types and neurochemicals that promote pair bonding behaviour — for the first time in a wild animal. This project should provide significant benefits by increasing our knowledge of how pair bonds promote wellness.Read moreRead less
ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial ....ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial concepts into statistical analysis and modelling, powerful visualisation of information, and the building spatial decision support systems, to provide an improved evidence base and better informed decision-making to address the significant challenges facing Australia's people and its places.Read moreRead less
Improving the health and wellbeing of poorly housed Australians: understanding and responding to multiple housing deficit. Australia is currently in a housing crisis, with many escalating problems, including poor affordability, chronic undersupply, homelessness, insecurity in the private rental market and a shrinking public housing sector. While some Australians are unaffected, increasing numbers of already vulnerable people experience multiple housing problems. This project aims to develop a ne ....Improving the health and wellbeing of poorly housed Australians: understanding and responding to multiple housing deficit. Australia is currently in a housing crisis, with many escalating problems, including poor affordability, chronic undersupply, homelessness, insecurity in the private rental market and a shrinking public housing sector. While some Australians are unaffected, increasing numbers of already vulnerable people experience multiple housing problems. This project aims to develop a new theoretical framework for focusing on Australians who experience multiple housing problems. It aims to identify who will be affected, how this will play out on individual health and wellbeing, and how governments can best respond. It will provide essential evidence and intervention tools for understanding and improving the lives of the most vulnerable.Read moreRead less
Drug Targeting to Immune Cells Using Modified Inulin Particles. Vaxine Pty Ltd is an Australian biotechnology company that has discovered specific particulate forms of inulin that are efficiently internalised by human immune cells. This project aims to exploit cell migration to injury and infection sites by attaching drugs to inulin particles creating a targeted drug delivery system. This system will transport drugs specifically to afflicted areas, reducing systemic concentrations of drugs and h ....Drug Targeting to Immune Cells Using Modified Inulin Particles. Vaxine Pty Ltd is an Australian biotechnology company that has discovered specific particulate forms of inulin that are efficiently internalised by human immune cells. This project aims to exploit cell migration to injury and infection sites by attaching drugs to inulin particles creating a targeted drug delivery system. This system will transport drugs specifically to afflicted areas, reducing systemic concentrations of drugs and hence the risks of dose related side effects. This project has potential both to improve healthcare and to encourage the growth of expertise in the biotechnology industry in Australia.Read moreRead less