Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560657
Funder
Australian Research Council
Funding Amount
$740,000.00
Summary
Ultra-High Resolution NMR Imaging System for Nanotechnology including Nanobiotechnology. The ultra-high resolution imaging NMR spectrometer at the centre of this application is a generation ahead of comparable facilities in Australia and will extend the research capacity of numerous research groups comprising in excess of 50 academics and postgraduate students. The aims and significance of this infrastructure lie in it being one of the centrepieces of the partner institutions' aspirations to tak ....Ultra-High Resolution NMR Imaging System for Nanotechnology including Nanobiotechnology. The ultra-high resolution imaging NMR spectrometer at the centre of this application is a generation ahead of comparable facilities in Australia and will extend the research capacity of numerous research groups comprising in excess of 50 academics and postgraduate students. The aims and significance of this infrastructure lie in it being one of the centrepieces of the partner institutions' aspirations to take Australia to the cutting edge of nanotechnology and cognate disciplines many of which are areas of national priority. The expected manifold outcomes include research of the highest rank into fundamental problems of drug development through to applied outcomes such as new nanomaterials and improved horticulture/fruit preservation.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989648
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
Optical test-bed facility for mid infrared components for sensing, imaging and astrophotonics. This test facility will enable Australian researchers to validate optical components and technologies at wavelengths from 2.5 to 20 microns, that are crucial for a wide range of applications including biophotonics, sensing, imaging, defense, and astro-photonics. Technologies related to the Mid IR are
expected to have a significant impact on quality of life and global economy. It will enable Australi ....Optical test-bed facility for mid infrared components for sensing, imaging and astrophotonics. This test facility will enable Australian researchers to validate optical components and technologies at wavelengths from 2.5 to 20 microns, that are crucial for a wide range of applications including biophotonics, sensing, imaging, defense, and astro-photonics. Technologies related to the Mid IR are
expected to have a significant impact on quality of life and global economy. It will enable Australian researchers to achieve a major impact in many areas of Mid IR fundamental and applied science as well as industry sectors such as sensing, biophotonics, defence, health, bio-security and imaging. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0238898
Funder
Australian Research Council
Funding Amount
$352,000.00
Summary
Novel Optical Microprobes - fluorescence excitation, lifetime and surface enhanced Raman spectroscopies. State-of-the-art technologies in microscopy will be combined with the versatility and diagnostic power of spectroscopy for the analysis and identification of materials by methods sensitive to chemical structure as well as spatial inhomogeneity. The proposed systems will operate within an existing multi-user optical characterisation facility at Macquarie University thus supporting the research ....Novel Optical Microprobes - fluorescence excitation, lifetime and surface enhanced Raman spectroscopies. State-of-the-art technologies in microscopy will be combined with the versatility and diagnostic power of spectroscopy for the analysis and identification of materials by methods sensitive to chemical structure as well as spatial inhomogeneity. The proposed systems will operate within an existing multi-user optical characterisation facility at Macquarie University thus supporting the research of an established and expanding network of researchers in the Sydney area and in Melbourne. The suite of instruments will provide new and exciting avenues for interdisciplinary research between the physical and biological sciencesRead moreRead less
Regulation of large artery stiffness by endothelium-derived mediators and effects on the arterial pressure waveform. Stiffening of arteries is an important cardiovascular risk factor and increases with age, high blood pressure, high cholesterol and diabetes. Cells that line the blood vessels (endothelial cells), become damaged and this reduces the available amount of a dilator substance, nitric oxide, and increases the activity of a constrictor substance, endothelin-1. We have shown that nitric ....Regulation of large artery stiffness by endothelium-derived mediators and effects on the arterial pressure waveform. Stiffening of arteries is an important cardiovascular risk factor and increases with age, high blood pressure, high cholesterol and diabetes. Cells that line the blood vessels (endothelial cells), become damaged and this reduces the available amount of a dilator substance, nitric oxide, and increases the activity of a constrictor substance, endothelin-1. We have shown that nitric oxide regulates large artery stiffness and we believe that other endothelial mediators are also important regulators. Therefore, we aim to explore this in a series of studies. Regulation of stiffness of large arteries will improve treatment of age-related cardiovascular disease (eg isolated systolic hypertension)Read moreRead less
Special Research Initiatives - Grant ID: SR0354576
Funder
Australian Research Council
Funding Amount
$30,000.00
Summary
Spatially Integrated Social Science Research in Australia. Rapid change across society has resulted in shifts to the scope of social science research including the emergence of space and place as an important concept. Across research fields the result has been that a range of innovative and unique techniques, methodologies and theories that are space based are now being developed. While research is progressing rapidly, it is undertaken in parallel by researchers who can not always collaborate. ....Spatially Integrated Social Science Research in Australia. Rapid change across society has resulted in shifts to the scope of social science research including the emergence of space and place as an important concept. Across research fields the result has been that a range of innovative and unique techniques, methodologies and theories that are space based are now being developed. While research is progressing rapidly, it is undertaken in parallel by researchers who can not always collaborate. Recognising these advances, this initiative focuses on harnessing Australia's capacity and potential in the use of spatially based methods and theories and brings researchers together in collaboration across a number of fields. Read moreRead less
ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial ....ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial concepts into statistical analysis and modelling, powerful visualisation of information, and the building spatial decision support systems, to provide an improved evidence base and better informed decision-making to address the significant challenges facing Australia's people and its places.Read moreRead less
Understanding contested human-plant geographies for urban greening success. Urban greening is vital for sustainable, liveable and climate-adapted cities. However, conflicts over urban greening continue to cause delays and even failure of initiatives. Such disputes, and the diverse socio-cultural relations that drive them, remain poorly understood. In ground-breaking research employing innovative concepts and methods developed by the team, this project aims to generate new knowledge about how peo ....Understanding contested human-plant geographies for urban greening success. Urban greening is vital for sustainable, liveable and climate-adapted cities. However, conflicts over urban greening continue to cause delays and even failure of initiatives. Such disputes, and the diverse socio-cultural relations that drive them, remain poorly understood. In ground-breaking research employing innovative concepts and methods developed by the team, this project aims to generate new knowledge about how people experience urban greening in their everyday lives and how urban greening is contested in three Australian cities. Expected outcomes include new, crucial understandings of key human-plant relationships, facilitated international collaborations, and significant findings for improving urban greening policies and governance.Read moreRead less
Disability and ability: how young people with impairments make the transition to adulthood. Compared to their able-bodied peers, 15-29 year olds with disabilities have an increased risk of negative social, physical and mental health outcomes. By analysing the life histories of 100 young people with physical impairments and tracking their development over four years, this project will explore how to reduce these risks.
Industrial Transformation Training Centres - Grant ID: IC170100016
Funder
Australian Research Council
Funding Amount
$3,123,492.00
Summary
ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therap ....ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therapeutics. The use of an individual patient’s cellular and molecular research findings will ultimately enable personalised diagnostic and therapeutic decisions.Read moreRead less
How cholesterol optimises ion pump function in animal membranes. This project aims to determine how cholesterol optimises ion pump function in animal membranes and to identify the major effects of cholesterol and its derivatives on membranes’ physical properties. All animal cells need high levels of cholesterol in the plasma membrane for survival. Insufficient cholesterol biosynthesis leads to severe birth defects. The need for cholesterol is likely linked to its acceleration of sodium pump acti ....How cholesterol optimises ion pump function in animal membranes. This project aims to determine how cholesterol optimises ion pump function in animal membranes and to identify the major effects of cholesterol and its derivatives on membranes’ physical properties. All animal cells need high levels of cholesterol in the plasma membrane for survival. Insufficient cholesterol biosynthesis leads to severe birth defects. The need for cholesterol is likely linked to its acceleration of sodium pump activity, essential to physiological processes including cell division, nerve, muscle and kidney activity. An expected benefit of the project is knowledge on the molecular origin of diseases associated with inhibition of cholesterol production, and a more complete understanding of the crucial role played by cholesterol via its effect on ion pumping towards the healthy functioning of vital organs, particularly in heart muscle and nerves.Read moreRead less