Complex nano-systems for highly selective imaging and targeting of cells. The aim of the project is to design multi-functional nanoparticles that can be tracked by multiple bio-imaging techniques, such as magnetic resonance imaging (MRI) and positron emission tomography imaging. The nanoparticles are designed to be targetable to specific cell populations and capable of delivering drugs. The project plans to concentrate the MRI-active gadolinium into nanoparticles to generate enhanced images, and ....Complex nano-systems for highly selective imaging and targeting of cells. The aim of the project is to design multi-functional nanoparticles that can be tracked by multiple bio-imaging techniques, such as magnetic resonance imaging (MRI) and positron emission tomography imaging. The nanoparticles are designed to be targetable to specific cell populations and capable of delivering drugs. The project plans to concentrate the MRI-active gadolinium into nanoparticles to generate enhanced images, and to combine this with other imaging modalities to facilitate tracking and sensitivity. Expected outcomes would enable a new approach to extremely accurate and sensitive imaging of tumours to enable the imaging of much smaller tumours than currently possible. This would allow early therapeutic intervention. The nanoparticles are also designed to deliver a therapeutic payload to specific locations, avoiding systemic delivery of toxic anticancer drugs.Read moreRead less
Prerequisite conditions for Indigenous nation self-government. This project aims to produce new knowledge about Indigenous nation building (INB) processes. Based on research that self-governance increases Indigenous socioeconomic and community capacity, this project will collaborate with two Aboriginal communities to investigate factors that impact the transition from 'identifying' to 'organising' as political collectives to enable self-governance. Such knowledge has the potential to directly co ....Prerequisite conditions for Indigenous nation self-government. This project aims to produce new knowledge about Indigenous nation building (INB) processes. Based on research that self-governance increases Indigenous socioeconomic and community capacity, this project will collaborate with two Aboriginal communities to investigate factors that impact the transition from 'identifying' to 'organising' as political collectives to enable self-governance. Such knowledge has the potential to directly contribute to increased wellbeing for Indigenous communities as they define it. It aims to contribute to Australian and international Indigenous governance, political science and Indigenous methodologies literatures. The project could significantly benefit Indigenous peoples, the broader Australian community, Australian governments, and Australian and international INB researchers.Read moreRead less
Big-Picture Bioethics: policy-making and liberal democracy. We live an era of rapid growth in biotechnology generating new and difficult ethical questions that need to be tackled by bioethicists and politicians. This project goes beyond typical approaches in bioethics to explore the "big picture": how policies are generated in ethically-contentious domains. It is important to examine how the values of different stakeholders are reflected in such processes to ensure that they are in accordance wi ....Big-Picture Bioethics: policy-making and liberal democracy. We live an era of rapid growth in biotechnology generating new and difficult ethical questions that need to be tackled by bioethicists and politicians. This project goes beyond typical approaches in bioethics to explore the "big picture": how policies are generated in ethically-contentious domains. It is important to examine how the values of different stakeholders are reflected in such processes to ensure that they are in accordance with Australia's commitment to fostering a multicultural, pluralistic, democratic society. This project will produce practical recommendations for refining public consultation in healthcare policy-making through an examination of three relevant contentious case studies in Australia with comparison to Canada.Read moreRead less
Enhanced Humans, Robotics and the Future of Work. The aim of the project is to generate new and powerful understandings of the social consequences of robotics and artificial intelligence. The project aims to develop an understanding of technologically-mediated mobility processes and test their capacity to address such issues as social futures and the sorts of digital skills that Australians will require for future jobs. It plans to use social theory to explore technological scenarios and hypothe ....Enhanced Humans, Robotics and the Future of Work. The aim of the project is to generate new and powerful understandings of the social consequences of robotics and artificial intelligence. The project aims to develop an understanding of technologically-mediated mobility processes and test their capacity to address such issues as social futures and the sorts of digital skills that Australians will require for future jobs. It plans to use social theory to explore technological scenarios and hypotheses concerning possible societal futures in Australia and beyond. Project outcomes may inform social science and contribute to worldwide efforts to solve global policy problems from work and unemployment to lifestyle change.Read moreRead less
Skin penetration of nanoparticles promoted by particle design, formulation and application method. This project seeks to better define the determinants of nanoparticle skin penetration and subsequent disposition in the body. The data would be used to guide minimal skin penetration of 'undesirable' nanoparticles and the properties required of 'safe' nanoparticles to enable effective human skin delivery in cosmetic and dermatological products.
Identifying optimal daily levels of movement behaviours in early childhood. This project aims to discover how much physical activity, sedentary behaviour and sleep young children need each day to best support their development. Through the creation of an international database and the application of innovative analytics, the project seeks to determine the optimal daily balance of these behaviours that results in the best developmental outcomes for young children. The project is expected to infor ....Identifying optimal daily levels of movement behaviours in early childhood. This project aims to discover how much physical activity, sedentary behaviour and sleep young children need each day to best support their development. Through the creation of an international database and the application of innovative analytics, the project seeks to determine the optimal daily balance of these behaviours that results in the best developmental outcomes for young children. The project is expected to inform national movement behaviour guidelines. The expected benefit for parents and professionals is improved confidence in supporting children’s physical activity, sedentary behaviour and sleep. The expected benefit for children is positive development, given the broad impacts of these behaviours on health and well-being.Read moreRead less
Testing the integration and differentiation of national employment systems: multinational enterprises in an international comparative context. Multinational enterprises play a leading role in shaping employment practices as their power disproportionately influences the direction of change in managing people. This project, conducted across six countries, enhances our understanding of how these organisations influence and shape the employment practices and systems in host contexts.
Situational Assessment as a Marker of Cognitive Skill Decay. The aim of this study is to test how differences in exposure to complex tasks change the capacity for situational assessment. Amongst drivers, pilots and electricity controllers, the capacity to assess and respond effectively to changes in the operational environment are critical in sustaining performance and ensuring the safety and security of the public. Establishing the nature of this relationship will enable, for the first time, ob ....Situational Assessment as a Marker of Cognitive Skill Decay. The aim of this study is to test how differences in exposure to complex tasks change the capacity for situational assessment. Amongst drivers, pilots and electricity controllers, the capacity to assess and respond effectively to changes in the operational environment are critical in sustaining performance and ensuring the safety and security of the public. Establishing the nature of this relationship will enable, for the first time, objective measures of cognitive skill decay. In evaluating cognitive skill decay more accurately, we will provide a cost-effective, easily administered tool, enabling practitioners to identify and address areas of development and providing data to anticipate when cognitive skill decay is most likely to occur.Read moreRead less
Taking control: variations in forced psychiatric treatment in the community. This interdisciplinary project aims to produce a comprehensive understanding of the drivers underpinning variations in the use of legal orders to enforce psychiatric treatment in the community without consent. Australia’s rate of use of these controversial orders is very high and there are unexplained variations in rates of use within and between jurisdictions, with some minority groups disproportionately affected. Unco ....Taking control: variations in forced psychiatric treatment in the community. This interdisciplinary project aims to produce a comprehensive understanding of the drivers underpinning variations in the use of legal orders to enforce psychiatric treatment in the community without consent. Australia’s rate of use of these controversial orders is very high and there are unexplained variations in rates of use within and between jurisdictions, with some minority groups disproportionately affected. Uncovering this knowledge will act as a form of procedural justice for those who have had their human rights limited by compulsion. This knowledge is expected to lead to innovations in law and policy, with subsequent organisational and system improvements, generating profound benefits for those affected by forced treatment. Read moreRead less
Urban cultural policy and the changing dynamics of cultural production. This project aims to identify new directions for urban cultural policy by conducting international comparative research around the emerging nexus between the cultural industries and manufacturing. Policies that govern Australia’s cultural economy focus predominately on cultural consumption. This approach does not account for the changing dynamics of the cultural economy, particularly the emergent relationships with a complex ....Urban cultural policy and the changing dynamics of cultural production. This project aims to identify new directions for urban cultural policy by conducting international comparative research around the emerging nexus between the cultural industries and manufacturing. Policies that govern Australia’s cultural economy focus predominately on cultural consumption. This approach does not account for the changing dynamics of the cultural economy, particularly the emergent relationships with a complex urban manufacturing sector. As a result, many innovation, employment and urban development opportunities around cultural production are unrealised. The results of the project are expected to yield insights into urban industry dynamics and change how Australians conceptualise urban cultural policy.Read moreRead less