Multifunctional biodegradable nanoparticles for enhanced DNA vaccine delivery. DNA vaccine, which shows better immunological and economic merits than conventional vaccines, suffers clinical failure due to the difficulty of delivering intact DNA molecules to relevant cells. This project seeks to develop smart polymer nanospheres to protect the DNA molecules from premature degradation in order to improve its efficacy.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100125
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Advanced fluorescence imaging facility: from super high resolution to whole animal imaging. The establishment of this advanced fluorescence imaging facility will provide cutting-edge infrastructure to examine cells, pathogens and interactions between engineered drug delivery systems in both cells and whole animals. The facility will foster the development of new nanomedicines.
Synergistic nanostimulation of nerve cells using atomic force microscopy technology. The research will develop multifunctional nanoelectrodes for neural prosthetic devices of the future. They will be smaller and more effective, enabling integration with single neural networks in the body, to improve the clinical treatment of severe neurological disorders and loss of sensory (hearing and vision) and motor functions.
Discovery Early Career Researcher Award - Grant ID: DE180100775
Funder
Australian Research Council
Funding Amount
$368,446.00
Summary
Using nanostructured scaffolds to understand and engineer neuronal circuits. This project aims to understand the formation of neuronal circuits in the brain. While the role of biochemical features in the brain is well understood, it is not clear how the biophysical properties of the brain affect circuit formation. The outcomes of this project will improve our understanding of neuronal circuit formation as well as provide design rules for creating scaffolds to repair neuronal circuits after brain ....Using nanostructured scaffolds to understand and engineer neuronal circuits. This project aims to understand the formation of neuronal circuits in the brain. While the role of biochemical features in the brain is well understood, it is not clear how the biophysical properties of the brain affect circuit formation. The outcomes of this project will improve our understanding of neuronal circuit formation as well as provide design rules for creating scaffolds to repair neuronal circuits after brain damage. This project will integrate Australia’s strengths in nanotechnology and neurosciences, bringing Australian research at the forefront of neural engineering.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100100
Funder
Australian Research Council
Funding Amount
$440,000.00
Summary
Cytometer by Time of Flight (CyTOF): A New Paradigm in Cytometry. Cytometer by Time of Flight (CyTOF) - a new paradigm in cytometry: The acquisition of a Cytometer by Time of Flight will allow multiparametric characterisation of biological systems and quantitative analysis of nano-bio interactions at the single cell level. The convergence of nanotechnology with biomedicine offers unprecedented opportunities for biological applications, including targeted therapeutics. One of the major challenges ....Cytometer by Time of Flight (CyTOF): A New Paradigm in Cytometry. Cytometer by Time of Flight (CyTOF) - a new paradigm in cytometry: The acquisition of a Cytometer by Time of Flight will allow multiparametric characterisation of biological systems and quantitative analysis of nano-bio interactions at the single cell level. The convergence of nanotechnology with biomedicine offers unprecedented opportunities for biological applications, including targeted therapeutics. One of the major challenges lies in understanding the complex interactions between nanoengineered materials and biological systems.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100163
Funder
Australian Research Council
Funding Amount
$700,000.00
Summary
Live Cell Super Resolution Imaging Facility. The recent convergence of nanoscience and biology heralds a new era for the development of new biotechnologies. Advances in this field are critically dependent on being able to explore and understand the interactions of nanomaterials with cells in their live, dynamic state. This proposal aims to establish a Live Cell Super Resolution Imaging Facility, which will enable dynamic nanomaterial–cell interactions to be interrogated. This facility will under ....Live Cell Super Resolution Imaging Facility. The recent convergence of nanoscience and biology heralds a new era for the development of new biotechnologies. Advances in this field are critically dependent on being able to explore and understand the interactions of nanomaterials with cells in their live, dynamic state. This proposal aims to establish a Live Cell Super Resolution Imaging Facility, which will enable dynamic nanomaterial–cell interactions to be interrogated. This facility will underpin leading research programs at The University of Melbourne, Monash University, RMIT, the Peter MacCallum Cancer Centre and the Bionics Institute, promoting synergies across the physical and biological sciences for generating new knowledge and advancing bio-nanoscience and technology.Read moreRead less
Bioprogramming the behaviour of nanoparticles in live cells by nanoscopy . The project aims to develop safer materials that are sustainably sourced from sweet corn, and investigate using advanced imaging technologies, how these materials are processed in biological systems, including human and plant cells. This project expects to generate new knowledge in the optimal design of materials that can be used safely and effectively in biological applications in medicine and in agriculture. Expected ou ....Bioprogramming the behaviour of nanoparticles in live cells by nanoscopy . The project aims to develop safer materials that are sustainably sourced from sweet corn, and investigate using advanced imaging technologies, how these materials are processed in biological systems, including human and plant cells. This project expects to generate new knowledge in the optimal design of materials that can be used safely and effectively in biological applications in medicine and in agriculture. Expected outcomes of this multidisciplinary project include a library of highly biocompatible nanomaterials and expanded knowledge on imaging technologies and structure-function relationship of nanomaterials in biological cells. This should provide significant benefits, such as improved crop yields and safer transfection agents.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100146
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Multiphoton confocal microscope for high-speed, deep tissue imaging and multimodal nanoscale characterisation. This facility will provide the ability to optically section deep nanoparticles, cells, tissues and whole animals at high speed with unsurpassed spatial resolution at the atomic level. It will give biomedical, physical and life scientists and materials engineers the opportunity to image a range of dynamic processes and reconstruct these in three dimensions for the first time.
Porous Silica-Based Nanocapsules for Targeted and Controlled Release of Biocides. The project will lead to significant advances in nanotechnology and agrichemical biocide applications. A highly efficient insect control technology will be developed, that will be cost-effective with the ability for targeted control and release of biocides. The encapsulation technology will reduce the total usage and costs of biocides thus benefit the environment in terms of reduced environment pollution and enhanc ....Porous Silica-Based Nanocapsules for Targeted and Controlled Release of Biocides. The project will lead to significant advances in nanotechnology and agrichemical biocide applications. A highly efficient insect control technology will be developed, that will be cost-effective with the ability for targeted control and release of biocides. The encapsulation technology will reduce the total usage and costs of biocides thus benefit the environment in terms of reduced environment pollution and enhanced ecological safety.Read moreRead less