Thioamide ligations: new technologies for peptide and protein synthesis. This project aims to develop novel amide-bond forming reactions for the chemical synthesis of peptides and proteins. New peptide ligation strategies, including an asparagine-based ligation and a residue-independent ligation will be developed that exploit the recent discovery of silver-promoted coupling reactions of thioamides. A novel late-stage, chemo-selective assembly of N-glycosylated asparagine residues in peptides and ....Thioamide ligations: new technologies for peptide and protein synthesis. This project aims to develop novel amide-bond forming reactions for the chemical synthesis of peptides and proteins. New peptide ligation strategies, including an asparagine-based ligation and a residue-independent ligation will be developed that exploit the recent discovery of silver-promoted coupling reactions of thioamides. A novel late-stage, chemo-selective assembly of N-glycosylated asparagine residues in peptides and proteins will also be developed. The outcomes of this research will lead to breakthroughs in synthetic methodologies for the assembly and functionalisation of peptides and proteins, thereby enabling access to a range of homogeneous, post translationally modified proteins though total chemical synthesis. These research outcomes will expand Australia's research capability and global competitiveness in the field of biotechnology, delivering significant benefits to the third largest manufacturing sector in Australia.Read moreRead less
Modular Vortex Fluidic Mediated Molecular Transformations. The project aims to develop the use of electric and magnetic fields to control chemical and biochemical reactions in high shear thin films under readily scalable continuous flow conditions to then be able to precisely build complex functional molecules. Depending on the orientation, strength and frequency of external electric and magnetic fields, and novel shear stress induced electric fields in solution, rates of reactions can be enhanc ....Modular Vortex Fluidic Mediated Molecular Transformations. The project aims to develop the use of electric and magnetic fields to control chemical and biochemical reactions in high shear thin films under readily scalable continuous flow conditions to then be able to precisely build complex functional molecules. Depending on the orientation, strength and frequency of external electric and magnetic fields, and novel shear stress induced electric fields in solution, rates of reactions can be enhanced, with higher yields and tunable selectivity, and reduced waste and energy usage, which is not possible using traditional batch processing. This will be translated into molecular assembly line processing and the development of a new synthetic toolbox, with applications in preparing pharmaceuticals.
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