The Role Of Membrane Condensation In T Lymphocyte Activation And Signal Transduction
Funder
National Health and Medical Research Council
Funding Amount
$82,421.00
Summary
T cell lymphocytes are essential cells in our immune system. They respond to signals from foreign bodies to mount an immune response. Many diseases arise from errors in their activation processes. The key steps in the translation of the initial arrival of a foreign-body to a T cell into an immune response will be examined in these studies, where we will look at the cooperation of components of the cell membrane during T cell activation. This will help us to understand and treat immune disorders.
The Genetic Study Of Diabetic Retinopathy Risk In Type 1 Diabetes Mellitus
Funder
National Health and Medical Research Council
Funding Amount
$32,628.00
Summary
Type 1 diabetes is a disorder leading to high blood sugars, which can damage the small blood vessels of the the back of the eye and potentially lead to blindness. However not all diabetics will develop blinding eye disease. Our project aims to find the genes that contribute to the development of blinding diabetic eye disease so that patients who carry the genes can be managed and treated appropriately. This will help to reduce the incidence of blindness related to diabetic eye disease.
Regulation Of Mesenchymal Stem Cell Paracrine Activity In Post-myocardial Infarction Cardiac Repair
Funder
National Health and Medical Research Council
Funding Amount
$73,212.00
Summary
Heart failure remains to be a major cause of morbidity in Australian population. After myocardial infarction, the damaged heart undergoes a series of compensatory adjustments to maintain the workload, termed cardiac remodeling. The resultant beneficial response in the short term eventually becomes deleterious. Using adult stem cells, the project aims to develop a better treatment to manipulate the progression of such responses and prevent hearts from entering the end stage heart failure.
Lifetime Alcohol Consumption And Risk Of Mortality And Morbidity: The Melbourne Collaborative Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$71,765.00
Summary
Australia has a high alcohol consumption rate with many people drinking above recommended national guidelines. Alcohol is attributed with a dual effect on disease outcomes: as a risk factor for cardiovascular disease, cancer and liver cirrhosis and a protective effect on coronary heart disease and type 2 diabetes mellitus, depending on the volume and pattern of consumption. We aim to study these associations using lifetime alcohol consumption data from the Melbourne Collaborative Cohort Study.