Longitudinal Study Of Modifiable Influences For The Development Of Harmful Young Adult Alcohol Use And Related-problems.
Funder
National Health and Medical Research Council
Funding Amount
$1,484,496.00
Summary
Young adulthood is a time of high vulnerability for alcohol use problems that are the major preventable contributor to death and injury in this age period. This 5-year project will identify modifiable influences in adolescence and young adulthood that contribute to harmful alcohol use. A cohort of almost 3,000 young people initially recruited in Victoria in 2002 (aged 11 to 15) will be followed for two further waves of data collection in 2010-11 (age 19 to 23) and 2012-13 (age 21 to 25).
A Randomized Controlled Trial Of A General Practice Based Intervention To Prevent Chronic Vascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$774,357.00
Summary
Chronic diseases such as heart disease, stroke and diabetes contribute greatly to the burden of disease in Australian society. Prevention of these conditions is a high priority for the health system. There is increasing evidence for the effectiveness of interventions to prevent chronic disease in those at high risk. However the feasibility of intervening through general practice and other existing services has not been demonstrated. We have previously conducted research on a structured approach ....Chronic diseases such as heart disease, stroke and diabetes contribute greatly to the burden of disease in Australian society. Prevention of these conditions is a high priority for the health system. There is increasing evidence for the effectiveness of interventions to prevent chronic disease in those at high risk. However the feasibility of intervening through general practice and other existing services has not been demonstrated. We have previously conducted research on a structured approach to helping patients with risk factors for chronic disease (such as smoking, poor nutrition, hazardous alcohol consumption and physical inactivity) including both cardiovascular disease and diabetes in general practice. This study aims to evaluate the impact of recalling patients to general practice for a visit to assess their risk of chronic disease and to help them to lower their risk by changes to smoking, diet, alcohol consumption and physical activity behaviours. Practices in the intervention group will receive training, practice visits, resources, and referral pathways to enable them to invite eligible patients to attend the practice for an assessment and management of their risk factors. This will include provision of education materials, support for behaviour change, referral to diet education and physical activity program and follow up. The feasibility of this type of vascular disease prevention intervention for high-risk patients has not been trialled previously in Australia. The findings of this research will help to inform Australian and State health policy especially the preventive care initiatives recently announced by the Council of Australian Governments. It will also inform practice leading to better guidelines for general practice preventive care, better support for general practice to provide preventive care for patients at risk of chronic disease and better support for patients to reduce their risk of chronic disease by changing their behaviour.Read moreRead less
Improving Metabolic Fitness In Aboriginal And Torres Straight Islander Women: A Pragmatic Controlled Trial Of Waist Loss
Funder
National Health and Medical Research Council
Funding Amount
$556,193.00
Summary
Torres Strait Islanders have the highest prevalence of diabetes in Australia and weight gain in young women can increase further the risk of diabetes for themselves and their babies. Waist loss can reduce the risk of diabetes and heart disease. A pilot study in the Torres Strait in 2007, has demonstrated that this is achievable and acceptable in young Indigenous women. This proposal aims to conduct a larger trial, to look at effectiveness and sustainability of waist loss in young women.
An International Randomised Trial Of Low-dose Aspirin To Prevent Recurrent Venous Thromboembolism (INSPIRE)
Funder
National Health and Medical Research Council
Funding Amount
$1,989,986.00
Summary
Patients who develop venous blood clots or pulmonary embolism, without an underyling cause, are at very high risk of recurrence once anticoagulant treatment (warfarin) is discontinued. The international INSPIRE trial is assessing whether low-dose aspirin treatment (a simple and cheap alternative to warfarin) is effective and safe in preventing further blood clots. If proven effective, aspirin could potentially prevent thousands of patients worldwide from experiencing such events.
Low-dose Aspirin To Prevent Recurrent Venous Thromboembolism (ASPIRE) Study: A Multicentre Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,108,600.00
Summary
In approximately one-third of patients who develop deep vein thrombosis or pulmonary embolism, this event is 'unprovoked' . These patients are at very high risk of recurrence once treatment with warfarin is discontinued. Warfarin treatment is very effective to prevent recurrence but is inconvenient because it has to be very closely monitored with blood tests and also causes serious bleeding complications in a significant number of patients. There are currently no other treatments available to pr ....In approximately one-third of patients who develop deep vein thrombosis or pulmonary embolism, this event is 'unprovoked' . These patients are at very high risk of recurrence once treatment with warfarin is discontinued. Warfarin treatment is very effective to prevent recurrence but is inconvenient because it has to be very closely monitored with blood tests and also causes serious bleeding complications in a significant number of patients. There are currently no other treatments available to prevent recurrent thrombosis. Low-dose aspirin treatment offers a simple, inexpensive, and widely practicable alternative to warfarin but has not yet been proven to be effective for preventing recurrent thrombosis. This study will investigate the effectiveness and safety of aspirin to prevent recurrence in patients with unprovoked deep vein thrombosis or pulmonary embolism who have completed standard anticoagulation with heparin and warfarin. If proven to be effective, aspirin could potentially prevent thousands of patients from experiencing recurrent venous thromboembolism or fatal pulmonary embolism worldwide and also save millions of dollars in health care costs each year.Read moreRead less
Cluster Randomised Controlled Trial Of An Innovative Intervention To Increase Childrens Physical Activity
Funder
National Health and Medical Research Council
Funding Amount
$505,530.00
Summary
Rates of childhood obesity are increasing and outdoor free play is decreasing. Research suggests that these patterns are inter-related, and that adults perceive outdoor free play to be risky for children. In this study we will reprioritise play, reframe teachers' perceptions of risk and modify the playground environment to increase children's physical activity. We will assess the effectiveness of this simple, cost-effective intervention in a randomised controlled trial.
The Future Of Tobacco Control: Exploring The Feasibility, Acceptability And Cost-effectiveness Of New Policy Directions
Funder
National Health and Medical Research Council
Funding Amount
$495,752.00
Summary
We will examine the practical feasibility, ethical and public acceptability, and likely cost effectiveness of a number of different ways of reducing tobacco smoking and the harm caused by smoking in Australia. These policy options will include: (1) more restrictive policies towards tobacco products (such as prohibiting tobacco smoking and creating a government monopoly on the manufacture and supply of tobacco); (2) encouraging smokers to switch from smoking cigarettes to less harmful ways of usi ....We will examine the practical feasibility, ethical and public acceptability, and likely cost effectiveness of a number of different ways of reducing tobacco smoking and the harm caused by smoking in Australia. These policy options will include: (1) more restrictive policies towards tobacco products (such as prohibiting tobacco smoking and creating a government monopoly on the manufacture and supply of tobacco); (2) encouraging smokers to switch from smoking cigarettes to less harmful ways of using nicotine, such as using nicotine patches or gum ; (3) using new biotechnologies to improve smokers chances of quitting (e.g. genetic screening of smokers to select the most effective way of helping them to stop smoking and vaccinating ex-smokers against the effects of nicotine); and (4) new biotechnologies that may prevent nonsmokers from beginning to smoke (e.g. vaccinating nonsmokers against the effects of nicotine) or reduce the chances of their developing tobacco-related diseases (e.g. screening the population for genes that predict an increased susceptibility to nicotine dependence and tobacco-related diseases). The project will provide important information that will assist government in formulating policies to reduce the rate of cigarette smoking in the Australian population below current levels.Read moreRead less
The Effects Of Mixing Alcohol And Prescription Drugs On Driving And Cognitive Performance: A Randomised Simulator Study.
Funder
National Health and Medical Research Council
Funding Amount
$495,226.00
Summary
A large proportion of traffic accidents are linked to alcohol and prescription drug use. There is poor understanding of these drugs on driving performance, both alone and in combination with alcohol. This study examines the effects of commonly used prescription medications (diazepam and codeine) and alcohol, in combination, on driving-related skills and cognitive performance in healthy volunteers. The results of this study will inform future policy, and clinical and public health strategies.
Optimal Design Of Antimalarial Population Pharmacokinetic Studies
Funder
National Health and Medical Research Council
Funding Amount
$110,300.00
Summary
Each year there are more than 500 million episodes of malaria and over a million deaths. One of the main causes of this burden is inadequate treatment of young children and pregnant women. This project will improve research methods for determining effective treatment for all malaria patients, which in turn, will improve cure rates and slow the emergence and spread of drug resistance.