Defining The Role Of Nlrp1 And The Inflammasome In Host Defence And Inflammatory Disease
Funder
National Health and Medical Research Council
Funding Amount
$634,459.00
Summary
The immune system protects the body from invading pathogens, but it can also attack the body causing inflammatory and autoimmune diseases like arthritis and multiple sclerosis. This project will focus on the molecular regulation of the ïinflammasomeÍ, a protein complex that senses invading pathogens and triggers the immune response. Understanding the inflammasome may hold the key to a better understanding of how the good and bad functions of the immune system can be balanced to prevent disease.
Control Of Combined Simian-human Immunodeficiency Virus Infection Utilising NK Cells Mediating Antigen-specific Antibody Dependent Cellular Cytotoxicity - A Novel Vaccine Modality
Funder
National Health and Medical Research Council
Funding Amount
$432,587.00
Summary
Recently, progress was made in developing a vaccine against HIV. Our laboratory was selected to join a global collaboration trying to elucidate the key to this success. Attention has focused on non-neutralizing antibodies and our laboratory has developed a unique expertise in detecting such immune responses. This research will define, purify and manufacture these antibodies and test their ability to prevent HIV in animals with the ultimate aim of producing a vaccine for human use.