Immunological mechanisms underlying the protective immune responses induced by botulinum oil adjuvanted vaccine. Botulism is recognised as an important bacterial pathogen in commercial beef cattle in Australia and around the world. Development of affective, well-researched vaccine against Clostridium botulinum is a high priority for the cattle industry. A novel oil adjuvanted vaccine (Singvac from Fort Dodge Pty Ltd) has advantage over conventional vaccines as it provides full protection follo ....Immunological mechanisms underlying the protective immune responses induced by botulinum oil adjuvanted vaccine. Botulism is recognised as an important bacterial pathogen in commercial beef cattle in Australia and around the world. Development of affective, well-researched vaccine against Clostridium botulinum is a high priority for the cattle industry. A novel oil adjuvanted vaccine (Singvac from Fort Dodge Pty Ltd) has advantage over conventional vaccines as it provides full protection following a single administration. The aims of this study are to investigate the immunological mechanisms underlying the protective response by this novel vaccine using bovine and murine models. This study will discover new control measures for botulism in Australia.Read moreRead less
An Open Source Approach to Understanding an Important Parasite Ion Pump. This project plans to synthesise new compounds that bind the protein ATP4, an essential ion pump in the malaria parasite. It plans to generate a three-dimensional map to understand how these compounds stop ATP4 from working. Several promising new medicines for malaria target ATP4, yet we do not understand properly how they do so. The project’s intended aims will be achieved using new methods in synthetic chemistry and membr ....An Open Source Approach to Understanding an Important Parasite Ion Pump. This project plans to synthesise new compounds that bind the protein ATP4, an essential ion pump in the malaria parasite. It plans to generate a three-dimensional map to understand how these compounds stop ATP4 from working. Several promising new medicines for malaria target ATP4, yet we do not understand properly how they do so. The project’s intended aims will be achieved using new methods in synthetic chemistry and membrane biology, and by leveraging global scientific inputs through online research methods allowing anyone to participate.Read moreRead less
Making Green Guard® greener: enhancing the efficacy of a biopesticide. The project aims to identify naturally occurring micro-organisms to increase the effectiveness of Green Guard ®, which is a biopesticide used against the Australian plague locust. The project will use next-generation sequencing and other molecular techniques to potentially identify candidate microbes or combinations of microbes that can be added to Green Guard to enhance locust susceptibility. The project also aims to quantif ....Making Green Guard® greener: enhancing the efficacy of a biopesticide. The project aims to identify naturally occurring micro-organisms to increase the effectiveness of Green Guard ®, which is a biopesticide used against the Australian plague locust. The project will use next-generation sequencing and other molecular techniques to potentially identify candidate microbes or combinations of microbes that can be added to Green Guard to enhance locust susceptibility. The project also aims to quantify the interactive impact of temperature and nutrition on immune function, disease resistance and host-plant quality of plague locusts; and to explore the combined effects of temperature, habitat and Green Guard, in combination with candidate microbes or pathogens, on the behaviour and collective movement of locusts. It is anticipated that this will have implications for management and control strategies.Read moreRead less