Low-Cost Portable Inhalation Therapy Platform For Needle-Free DNA-Based Influenza Vaccination
Funder
National Health and Medical Research Council
Funding Amount
$524,644.00
Summary
Influenza affects a large proportion of the global population and can result in many deaths in a pandemic. A DNA influenza vaccine overcomes the possibility of severe side effects associated with commonly used vaccines based on weakened viruses and can be rapidly produced and easily transported without refrigeration. DNA vaccines are however unstable and difficult to deliver. We propose to address this with a low-cost and portable handheld device which allows the vaccine to simply be inhaled.
Novel Inhalation Formulation Of Colistin And Combination Therapy Against Gram-negative 'superbugs'
Funder
National Health and Medical Research Council
Funding Amount
$513,896.00
Summary
Respiratory infections caused by multidrug-resistant Gram-negative bacteria are major health problems for Australians. Colistin is the last-resort defense in most cases. However, parenteral administration of colistin will cause serious side effects. This proposal applies an interdisciplinary approach using aerosol particle engineering, functional lung imaging and antimicrobial pharmacology to develop and characterise novel inhaled powder formulations of colistin and its rational combinations.
Engineering Powder Aerosols Of Antibacterial Nanomedicines For Treatment Of Respiratory Infections
Funder
National Health and Medical Research Council
Funding Amount
$195,338.00
Summary
This project aims to apply cutting-edge nanotechnology to develop new inhalation therapy for respiratory infections by delivering antibiotics directly to the lungs. The expected outcomes of this work are more efficacious, safer and cost effective treatments for patients suffering from respiratory infectious diseases such as pneumonia.
Rapid point-of-care detection of genomic variations for personalised medicine. Selecting treatment based on a person’s genetic profile can improve drug safety and efficacy, but the application is hampered by the inconvenience, slow result turnaround and high cost of current lab-based tests. Full implementation of personalised medicine in clinical practice requires a point-of-care testing system. This project aims to overcome the challenges involved in developing such a system by validating novel ....Rapid point-of-care detection of genomic variations for personalised medicine. Selecting treatment based on a person’s genetic profile can improve drug safety and efficacy, but the application is hampered by the inconvenience, slow result turnaround and high cost of current lab-based tests. Full implementation of personalised medicine in clinical practice requires a point-of-care testing system. This project aims to overcome the challenges involved in developing such a system by validating novel rapid genotyping methods and developing ultrasensitive real-time DNA detection that will be integrated on a single chip platform to facilitate a small, low cost and reliable test device. The technology will be readily adaptable to areas where prompt access to genomic information is valuable, such as disease diagnosis and risk prediction.Read moreRead less
Novel graphene nanostructures: modelling, synthesis, fabrication and characterisation. As a key nanomaterial for future electronics, graphene is rapidly becoming one of the most promising frontier areas of nanotechnology throughout the world. This project aims to develop a new class of graphene nanostructures that hold great potential for large-scale applications in the next generation nanoelectronic devices, sensors, solar cells and light emitting devices. This project will significantly enhan ....Novel graphene nanostructures: modelling, synthesis, fabrication and characterisation. As a key nanomaterial for future electronics, graphene is rapidly becoming one of the most promising frontier areas of nanotechnology throughout the world. This project aims to develop a new class of graphene nanostructures that hold great potential for large-scale applications in the next generation nanoelectronic devices, sensors, solar cells and light emitting devices. This project will significantly enhance the international competitiveness of Australia in the areas of new materials and nanotechnology and will help place Australia at the forefront of nanotechnology. This project will produce high quality PhD students in nanotechnology.Read moreRead less
Diamond glass: An all-carbon technology for neural networks and biosensing. This project aims to use plasma deposition to synthesise diamond glass with the highest purity and the most diamond-like character so that it meets the strict requirements for emerging device applications. The extreme properties of diamond glass arise from the diamond-like bonding of the majority of its atoms. This amorphous, wide bandgap semiconductor is also the hardest known glass. The maximum diamond-like content pos ....Diamond glass: An all-carbon technology for neural networks and biosensing. This project aims to use plasma deposition to synthesise diamond glass with the highest purity and the most diamond-like character so that it meets the strict requirements for emerging device applications. The extreme properties of diamond glass arise from the diamond-like bonding of the majority of its atoms. This amorphous, wide bandgap semiconductor is also the hardest known glass. The maximum diamond-like content possible in diamond glass coatings is unknown, so determining its ultimate performance is difficult. Expected applications include medical diagnostics, non-volatile memories and programmable chips.Read moreRead less
Surface Integrity Characterization of Sapphire Wafers for Wireless and Fibre Optic Semiconductor Industry. This project aims to uncover the mechanism of surface integrity in sapphire wafers and thus to establish its relationship with the quality processing of integrated circuits. The project will comprehensively consider surface damage, residual stresses, thermal shock and dislocation evolution as an organic whole to provide an effective solution to the problems in the current production practic ....Surface Integrity Characterization of Sapphire Wafers for Wireless and Fibre Optic Semiconductor Industry. This project aims to uncover the mechanism of surface integrity in sapphire wafers and thus to establish its relationship with the quality processing of integrated circuits. The project will comprehensively consider surface damage, residual stresses, thermal shock and dislocation evolution as an organic whole to provide an effective solution to the problems in the current production practice. Problems caused by unsatisfactory surface integrity represent a major outlay for the wireless and fibre optic semiconductor industry. The proposed research holds the very real possibility of reducing the capital cost and enhancing the quality of the integrated circuits of high capacity.Read moreRead less
Higher Order Effects in Miniaturized Piezoelectric Devices. The national benefits of this project are: (a) We will provide opportunities to two postdoctoral researchers to pursue cutting edge research on electromagnetic radiation/scattering and self-heating phenomena in microelectronic devices involving ultrathin lossy electrodes. (b) We will provide industry-oriented research on coating and shielding problems in microelectronic devices to two postgraduate students. (c) We will team up with worl ....Higher Order Effects in Miniaturized Piezoelectric Devices. The national benefits of this project are: (a) We will provide opportunities to two postdoctoral researchers to pursue cutting edge research on electromagnetic radiation/scattering and self-heating phenomena in microelectronic devices involving ultrathin lossy electrodes. (b) We will provide industry-oriented research on coating and shielding problems in microelectronic devices to two postgraduate students. (c) We will team up with world leading industrial partners and transfer high-tech know-how to Australia. (d) The outcomes of our research will position Australia as the prime focal point for the design, modelling and simulation of microacoustic devices.Read moreRead less
Unified platform for real time QA in radiation therapy in brachytherapy based on high resolution silicon detectors (Magic Plate). This project will design and manufacture new devices for measuring the amount of radiation given to the patient during radiotherapy. This will improve the accuracy and safety of cancer treatment as well as greatly reducing the time needed to perform essential safety checks.