Engineering functional nerves using microtailored culture systems. The aim of this work is to develop new culture systems for developing and growing nerves outside of the body. The project will generate knowledge and engineering technology for production of neural implants suitable for medical applications. The availability of engineered nerve grafts to repair neural injuries will improve patient health outcomes.
Genesis and evolution of coherent structures in wall-bounded turbulence. This project aims to capture conditions responsible for the generation of the coherent structures that are formed in wall-bounded turbulent flows, through the use of variational data assimilation and adjoint-based optimisation techniques. The project is expected to provide knowledge and intellectual property that is essential for the accurate modelling and prediction of the interaction between the ground-level activities li ....Genesis and evolution of coherent structures in wall-bounded turbulence. This project aims to capture conditions responsible for the generation of the coherent structures that are formed in wall-bounded turbulent flows, through the use of variational data assimilation and adjoint-based optimisation techniques. The project is expected to provide knowledge and intellectual property that is essential for the accurate modelling and prediction of the interaction between the ground-level activities like pollutant emissions and the atmosphere and the flow over vehicles through pipes, turbines and compressors. This project will provide benefits such as reducing the risk in environmental and commercial design and decision making and will facilitate new opportunities for the commercial development of devices to reduce drag and enhance mixing and heat transfer via the direct manipulation of coherent structures.Read moreRead less
A multiplex microscope platform to define molecular events in fluid systems. This project aims to develop a novel microscopy platform that will enable the visualisation and quantification of molecular events occurring under fluid shear stress. The project will generate new knowledge in platelet biology that will allow characterisation and prediction of key molecular and morphological changes occurring across a blood thrombus under flowing conditions as found in the blood vessels. These new tools ....A multiplex microscope platform to define molecular events in fluid systems. This project aims to develop a novel microscopy platform that will enable the visualisation and quantification of molecular events occurring under fluid shear stress. The project will generate new knowledge in platelet biology that will allow characterisation and prediction of key molecular and morphological changes occurring across a blood thrombus under flowing conditions as found in the blood vessels. These new tools and the imaging platform will have applications for researchers wishing to visualise small and rapid molecular events in four dimensions (length, width, height and across time) under fluid shear stress, which is applicable across a range of industries. The project expects to deliver the next generation of intravital microscopes that can visualise and quantify events in a challenging flow environment.Read moreRead less
A novel and efficient approach for optimisation involving iterative solvers. Computationally expensive simulations involving iterative solvers are increasingly being used in industry to assess performance of products and processes. Repeated use of such simulations is necessary to identify optimum solutions. Even with today's computing power, many such tasks remain computationally prohibitive. This project presents a novel approach to solve optimisation problems involving iterative solvers with l ....A novel and efficient approach for optimisation involving iterative solvers. Computationally expensive simulations involving iterative solvers are increasingly being used in industry to assess performance of products and processes. Repeated use of such simulations is necessary to identify optimum solutions. Even with today's computing power, many such tasks remain computationally prohibitive. This project presents a novel approach to solve optimisation problems involving iterative solvers with limited computing budget. A wide range of industries involved in product and process design would gain a significant competitive advantage from this unique technical innovation. In addition, this technology will be invaluable to uncover and understand complex natural phenomena.Read moreRead less
Towards an event based model of combustion generated sound. This proposal will develop new tools for predicting combustion generated sound. Since combustion noise often limits system performance, these new tools could be used to significantly reduce emissions of greenhouse gases and other pollutants from power generation and transportation.