Novel Strategies In Cancer Cell Invasion In High-density 3D Matrix
Funder
National Health and Medical Research Council
Funding Amount
$60,768.00
Summary
The use of high-density (HD) matrix to study cell invasion sets precedence in mimicking the HD breast tissue condition that pose a real cancer risk. Cell invasion promotes the spread of cancer causing organ failures and death. The aims of this project are to determine the molecular mechanisms and to isolate new regulatory markers of cell invasion into HD matrix. Putative markers will be confirmed by investigating their expression levels in tissue arrays of 195 breast cancer samples.
The Role Of IQGAP1 In Human High-Grade Glioma And Its Regulation By MiR-124-A
Funder
National Health and Medical Research Council
Funding Amount
$69,137.00
Summary
Survival rates for many cancers are improving, however, for most patients diagnosed with a high grade glioma (HGG) there is limited long term survival. The treatments administered have limited effectiveness due to extensive infiltration of the tumour cells. New therapeutic strategies targeting the invading cell population to further reduce tumour spread are needed. Hence, a better understanding of the mechanisms promoting glioma migration and invasion are urgently required in this fatal disease.
Molecular And Epidemiological Investigation Of Cutaneous Squamous Cell Carcinoma Of The Head And Neck With Perineural Invasion
Funder
National Health and Medical Research Council
Funding Amount
$42,862.00
Summary
Queensland has the highest recorded rates of skin cancer in the world. Invasion into nearby nerves or �perineural invasion� occurs in approximately 5% of cases. This signifies that the tumour is aggressive and able to spread along nerves back to the brain and reduce survival. Why some tumours invade nerves remains unclear. This project will study the factors involved and the characteristics of affected patients to enable a better understanding of the disease and potentially improve treatment.