Cell polarity is the property of cells to be spatially oriented in a tissue or organ. We have now shown that the gene Scribble, a key regulator of cell orientation, may keep tumour development in check. In this proposal, we will examine how disruption of Scribble promotes cancer using a combination of tissue culture studies and a newly established mouse model. Understanding how this new pathway can regulate tumour development may provide novel targets for therapeutic intervention in cancer.
Understanding The Regulation Of Cell Polarity In Development And Cancer
Funder
National Health and Medical Research Council
Funding Amount
$428,602.00
Summary
Cell polarity is the property of cells to be spatially oriented in a tissue or organ. We have now shown that the gene Scribble, a key regulator of cell orientation, may keep tumour development in check. In this proposal, we will examine how disruption of Scribble and associated molecules affects normal development and promotes cancer using a combination of tissue culture studies and a newly established mouse model. These studies may provide novel targets for therapeutic intervention in cancer.
The Tumour Suppressor Lgl In The Regulation Of Cell Signaling, Proliferation And Apoptosis
Funder
National Health and Medical Research Council
Funding Amount
$534,871.00
Summary
Cancer is a disease that affects 1-3 people at some point in their lifetime. Therefore, understanding what causes cancer is of major importance to medical science. This proposal focuses on a group of tumour suppressors, Scrib-Dlg-Lgl, which act in a common pathway to regulate cell polarity (cell shape) and proliferation. We have shown that Lgl also regulates cell death. This proposal focuses on understanding the mechanism by which Lgl regulates the cell proliferation and death machinery.