Tracking Epidermal Clonal Evolution During Skin Cancer Induction And Progression
Funder
National Health and Medical Research Council
Funding Amount
$558,168.00
Summary
Skin cancer is the most frequent form of cancer in Australia and in many parts of the world. It is strongly connected to ultraviolet radiation from the sun. In this project, we will use our capacity to track individual cells, to observe the heterogeneity of tumours and the lesions that precede them. We will show the importance of this heterogeneity in tumour progression unveiling the limits of current therapies against skin cancer.
Mitochondrially targeted anti-cancer drugs modulate the mitochondrial genome. Successful cancer management requires novel therapeutical approaches. This project will test the effect of a new class of compounds that target mitochondria, the powerhouse of the cells, where they suppress expression of mitochondrial genes. By this mechanism, cancers that are resistant to apoptosis induction can be inhibited.
Discovery Early Career Researcher Award - Grant ID: DE140100433
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
Optimising light harvesting using quantum transport. Observations of wavelike energy transport in photosynthetic systems have exposed the role of quantum mechanics in natural light harvesting. This project is a study of how light harvesting functions for an incoherent source like sunlight. In sunlight, energy transport occurs at steady state, a dramatically simpler regime than when a coherent source like lasers are used. This project will exploit this simplification to develop new methods for tr ....Optimising light harvesting using quantum transport. Observations of wavelike energy transport in photosynthetic systems have exposed the role of quantum mechanics in natural light harvesting. This project is a study of how light harvesting functions for an incoherent source like sunlight. In sunlight, energy transport occurs at steady state, a dramatically simpler regime than when a coherent source like lasers are used. This project will exploit this simplification to develop new methods for treating light harvesting in sunlight and apply them to a variety of natural and artificial systems. It will clarify how bacteria and plants harvest sunlight and lead to design principles that will enable artificial light harvesting to take advantage of quantum effects.Read moreRead less