Identification Of Genes For X-linked Mental Retardation.
Funder
National Health and Medical Research Council
Funding Amount
$675,228.00
Summary
We propose to identify novel heritable causes of intellectual disability using 22 large and well-characterised families from Australia. In these families we have refined the location of the genetic defect to the chromosome X and excluded the contribution of all so far known genes. We will achieve this using the technology of massive parallel sequencing. At the completion of the project we will have identified novel causes of intellectual disability and devised tests to identify them.
Transforming The Diagnosis And Management Of Severe Neurocognitive Disorders Through Genomics
Funder
National Health and Medical Research Council
Funding Amount
$2,499,330.00
Summary
Neurocognitive disorders (NCD) are one of the most common genetic conditions in our society and it results with a need for ongoing permanent care for many affected people. Until recently, only 30% of people with NCD could be diagnosed but this has changed with the availability of genomic testing where all genes can be tested at once. The use of genomics in the CRE will lead to new NCD genes being identified and this information being translated into a clinical setting.
Cultural heritage in the sustainability of remote planned communities. The project responds to one objective of ARC Linkage grants 'to support collaborative research on issues of benefit to regional and rural communities'. It will assist remote settlements struggling for survival because of the demise or downturn of specialised employment bases. Focusing on the heritage importance and attraction of planned settlements in particular, economic and social benefits include increased knowledge of the ....Cultural heritage in the sustainability of remote planned communities. The project responds to one objective of ARC Linkage grants 'to support collaborative research on issues of benefit to regional and rural communities'. It will assist remote settlements struggling for survival because of the demise or downturn of specialised employment bases. Focusing on the heritage importance and attraction of planned settlements in particular, economic and social benefits include increased knowledge of the design history and heritage of Australian post-WW2 planned special-purpose towns in international perspective; strategies for identifying how cultural heritage might be harnessed to revitalise and sustain at risk communities; and postgraduate training in applied history and heritage. Read moreRead less
The Role Of UPF3B And Nonsense Mediated MRNA Decay Surveillance In The Pathology Of Intellectual Disability.
Funder
National Health and Medical Research Council
Funding Amount
$789,954.00
Summary
Proper functioning of the nonsense mediated mRNA decay (NMD or 'mRNA police') is crucial for any cell to ensure normal development and function. When NMD is compromised the outcome is learning and memory problems, autism or schizophrenia. Under this project we study malfunctioning NMD using stem and neuronal cells derived from patients' skin cells. Some of the affected genes might be considered for therapeutic interventions. NMD is relevant to 1000s of human disorders and as such it is of fundam ....Proper functioning of the nonsense mediated mRNA decay (NMD or 'mRNA police') is crucial for any cell to ensure normal development and function. When NMD is compromised the outcome is learning and memory problems, autism or schizophrenia. Under this project we study malfunctioning NMD using stem and neuronal cells derived from patients' skin cells. Some of the affected genes might be considered for therapeutic interventions. NMD is relevant to 1000s of human disorders and as such it is of fundamental importance.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775716
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
Infrastructure for a Spatially Integrated Social Science e-Research Facility. The requested facility with its Nationally Distributed Socio-Spatial Data System and On-Line Analysis, Modeling and Visualisation Research Facility will enhance Australia's national research capacity for secondary data analysis and modeling of socio-spatial information with visualisation, substantially reducing the cost of innovative research conducted at various levels of spatial scale to investigate both local and na ....Infrastructure for a Spatially Integrated Social Science e-Research Facility. The requested facility with its Nationally Distributed Socio-Spatial Data System and On-Line Analysis, Modeling and Visualisation Research Facility will enhance Australia's national research capacity for secondary data analysis and modeling of socio-spatial information with visualisation, substantially reducing the cost of innovative research conducted at various levels of spatial scale to investigate both local and nationally significant demographic, social, economic and behavioural issues. It will deliver national/community benefits through enabling hundreds of researchers and graduate students across the university system to investigate demographic, economic and social issues at various levels of spatial scale.Read moreRead less
An integrated model for the assessment of urban sustainability. The redevelopment and improvement of outdated urban infrastructure and the establishment of new infrastructure to meet needs of a growing population and increased services is a challenge faced by urban planners and developers in most Australian cities. This research will develop a systems-based framework within which combinations of models and tools will be evaluated for inclusion in an integrated assessment tool. The tool will ena ....An integrated model for the assessment of urban sustainability. The redevelopment and improvement of outdated urban infrastructure and the establishment of new infrastructure to meet needs of a growing population and increased services is a challenge faced by urban planners and developers in most Australian cities. This research will develop a systems-based framework within which combinations of models and tools will be evaluated for inclusion in an integrated assessment tool. The tool will enable us to address urban growth and its inter-relationship with infrastructure systems and services, including transport, energy, water, affordable housing, education and other land-use issues in relation to a case study of urban development. Read moreRead less
Gambling-related harm in Northern Australia: A Geographic Information Systems (GIS)-based spatiotemporal analysis of venue catchments. There is growing national concern about the impact of electronic gaming (poker) machines yet little is known about the effects of this gambling in rural and remote areas of Australia. We will develop a database to define the geographic distribution of gambling impacts, the nature of high-risk venues, and the characteristics, both spatial and social, of vulnerable ....Gambling-related harm in Northern Australia: A Geographic Information Systems (GIS)-based spatiotemporal analysis of venue catchments. There is growing national concern about the impact of electronic gaming (poker) machines yet little is known about the effects of this gambling in rural and remote areas of Australia. We will develop a database to define the geographic distribution of gambling impacts, the nature of high-risk venues, and the characteristics, both spatial and social, of vulnerable communities. This will enable the design of much needed harm minimisation strategies and will provide regulatory bodies with insights into the capacity of local communities to absorb the impact of electronic gaming machine venues.Read moreRead less
Species and gene turnover across environmental gradients - a landscape-level approach to quantify biodiversity and resilience for climate adaptation. Biodiversity corridor planning in Australia desperately needs to progress beyond the simple linking up of remnant vegetation, based on aerial maps and start incorporating ecosystem features which will promote climate adaptation. This project will develop a new genomics method to assess ecosystem resilience for use in national biodiversity corridor ....Species and gene turnover across environmental gradients - a landscape-level approach to quantify biodiversity and resilience for climate adaptation. Biodiversity corridor planning in Australia desperately needs to progress beyond the simple linking up of remnant vegetation, based on aerial maps and start incorporating ecosystem features which will promote climate adaptation. This project will develop a new genomics method to assess ecosystem resilience for use in national biodiversity corridor planning.Read moreRead less
SOCIAL CAPITAL AND PUBLIC POLICY: HOW SOCIAL CAPITAL CAN INFORM PUBLIC POLICY INTERVENTIONS TO IMPROVE HEALTH AND REDUCE INEQUITIES. This project examines the ways in which social capital affects policy outcomes in Australia. The research aims to examine the processes underpinning the development and implementation of public sector initiatives designed to promote social capital and to identify the role that social capital may play in implementing policy designed to reduce economic and health in ....SOCIAL CAPITAL AND PUBLIC POLICY: HOW SOCIAL CAPITAL CAN INFORM PUBLIC POLICY INTERVENTIONS TO IMPROVE HEALTH AND REDUCE INEQUITIES. This project examines the ways in which social capital affects policy outcomes in Australia. The research aims to examine the processes underpinning the development and implementation of public sector initiatives designed to promote social capital and to identify the role that social capital may play in implementing policy designed to reduce economic and health inequities between different groups in the population. The research will lead to a number of outcomes, including an increased understanding of the value of social capital to policy makers and evidence based recommendations for policies and interventions designed to improve health and reduce inequities.Read moreRead less
Solving the problems of estimating extinction rates in recent and geological time. Human activity is causing species to go extinct at rates not seen for at least 65 million years: this is the sixth mass extinction event in the history of the Earth. This project will use state-of-the-art modelling tools applied to Australian and global species and land-use change data to quantify humanity's influence on recent and future extinctions.