Tissue Bio-physicochemical Quantification Using Magnetic Resonance Imaging. This project aims to develop novel magnetic resonance imaging methods to investigate tissue structure and function. Current MRI technologies use standard water-based contrast mechanisms to generate images with limited tissue information. In contrast, this project expects to provide a non-invasive, ultra-high-resolution MRI technology that measures the electrical, magnetic, and chemical signals generated from the human bo ....Tissue Bio-physicochemical Quantification Using Magnetic Resonance Imaging. This project aims to develop novel magnetic resonance imaging methods to investigate tissue structure and function. Current MRI technologies use standard water-based contrast mechanisms to generate images with limited tissue information. In contrast, this project expects to provide a non-invasive, ultra-high-resolution MRI technology that measures the electrical, magnetic, and chemical signals generated from the human body. Thus, the new imaging methods can probe deeper biological functionality while examining tissue structure. The potential benefits include: expanding the scope and capabilities of current MRI, facilitating a wide range of imaging-based research and applications, and accelerating knowledge expansion in life science.Read moreRead less
Atomic scale imaging with high coherence electrons and ions. This project aims to combine a cold atom electron-ion source with a commercial microscope column for atomic-scale imaging in biosciences and materials science. Nanoscale imaging with electron and ion microscopy are tools for investigating the world at the atomic scale, underpinning development in modern technologies from semiconductor devices to medical treatments. This project will use ideas from laser cooling of atoms and atom optics ....Atomic scale imaging with high coherence electrons and ions. This project aims to combine a cold atom electron-ion source with a commercial microscope column for atomic-scale imaging in biosciences and materials science. Nanoscale imaging with electron and ion microscopy are tools for investigating the world at the atomic scale, underpinning development in modern technologies from semiconductor devices to medical treatments. This project will use ideas from laser cooling of atoms and atom optics to achieve new imaging modalities for time-lapse imaging of fundamental processes at the nano-scale. It will allow increasingly small scale resolution of fundamental processes at the nano-scale.Read moreRead less
Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are inn ....Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are innovative semi-automated nephron visualisation and quantitation tools that enable efficient renal phenotyping. Techniques tailored to widely accessible preclinical research scanners are expected to accelerate research into genetic and environmental factors affecting kidney microstructure in embryonic and post-natal life.Read moreRead less