Atomic scale imaging with high coherence electrons and ions. This project aims to combine a cold atom electron-ion source with a commercial microscope column for atomic-scale imaging in biosciences and materials science. Nanoscale imaging with electron and ion microscopy are tools for investigating the world at the atomic scale, underpinning development in modern technologies from semiconductor devices to medical treatments. This project will use ideas from laser cooling of atoms and atom optics ....Atomic scale imaging with high coherence electrons and ions. This project aims to combine a cold atom electron-ion source with a commercial microscope column for atomic-scale imaging in biosciences and materials science. Nanoscale imaging with electron and ion microscopy are tools for investigating the world at the atomic scale, underpinning development in modern technologies from semiconductor devices to medical treatments. This project will use ideas from laser cooling of atoms and atom optics to achieve new imaging modalities for time-lapse imaging of fundamental processes at the nano-scale. It will allow increasingly small scale resolution of fundamental processes at the nano-scale.Read moreRead less
Impact of evaluation-based funding on the content of scientific research. Evidence suggests that evaluation-based funding mechanisms trigger adaptive behaviour in scientists, leading to unintended changes in knowledge production. However, there is no conclusive evidence about when (under what circumstances), how (by what processes) and with what effects researchers adapt to these mechanisms. This study aims to answer these crucial questions. To overcome the methodological weaknesses of earlier s ....Impact of evaluation-based funding on the content of scientific research. Evidence suggests that evaluation-based funding mechanisms trigger adaptive behaviour in scientists, leading to unintended changes in knowledge production. However, there is no conclusive evidence about when (under what circumstances), how (by what processes) and with what effects researchers adapt to these mechanisms. This study aims to answer these crucial questions. To overcome the methodological weaknesses of earlier studies, a comparative investigation of several research fields and universities will be conducted, combining for the first time: qualitative interviews, ethnographic observations and bibliometric studies. It will enhance Australian research policy with a critical assessment of existing research funding models.Read moreRead less
X-ray Ghost Imaging and Tomography. This project aims to achieve safer, faster, and cheaper 3D X-ray imaging through a technique known as ghost imaging. X-ray imaging provides valuable information about internal structures, however, X-rays are carcinogenic and exposure (or dose) should be limited. Ghost imaging is an unconventional technique developed with visible light that has many potential benefits over conventional imaging. This research group are world leaders in ghost imaging and expect t ....X-ray Ghost Imaging and Tomography. This project aims to achieve safer, faster, and cheaper 3D X-ray imaging through a technique known as ghost imaging. X-ray imaging provides valuable information about internal structures, however, X-rays are carcinogenic and exposure (or dose) should be limited. Ghost imaging is an unconventional technique developed with visible light that has many potential benefits over conventional imaging. This research group are world leaders in ghost imaging and expect to develop software and hardware techniques to realise its potential and extend it to ghost tomography. The focus of this project is on reducing cancer risk in medical imaging, and allowing real-time quality control for 3D printing in safety-critical industries such as aerospace.Read moreRead less
Learning clique potentials for high-order graphical models. This project aims to develop algorithms for computers to automatically learn about visual scenes and objects from images. Using our algorithms, computers will be able to find objects and describe scenes in single images or large image collections such as online photo albums.
Nano-reactors: Protein cages as reusable scaffolds for designer enzymes. This project aims to develop robust protein cages derived from the coats of viruses to contain heat-stable P450 enzymes, for use as specialised protein bio-catalysts in chemical industries. A valuable chemical precursor of renewable bio-plastics will be produced from seed oils by enzymes, reducing the use of fossil fuels. This synthetic biology approach combines biotechnology, nanotechnology and protein engineering to estab ....Nano-reactors: Protein cages as reusable scaffolds for designer enzymes. This project aims to develop robust protein cages derived from the coats of viruses to contain heat-stable P450 enzymes, for use as specialised protein bio-catalysts in chemical industries. A valuable chemical precursor of renewable bio-plastics will be produced from seed oils by enzymes, reducing the use of fossil fuels. This synthetic biology approach combines biotechnology, nanotechnology and protein engineering to establish a plant-based platform biotechnology for using enzymes as catalysts to make high-value molecules. The project aims to show how to engineer clean, sustainable chemistry in designer nano-environments. This should make synthetic processes more sustainable and enhance advanced chemical manufacturing in Australia.Read moreRead less
Controlling the rate of transcription and translation of Rubisco transgenes effectively in higher-plant plastids. Genetic transformation of the circular genome of the plastids provides a containable means for modifying plant growth by manipulating photosynthesis. Although the transformation mechanism is precise, predicting the level of foreign gene expression is difficult because the amounts of messenger RNA and protein produced by foreign genes in plastids varies widely, even when the protein a ....Controlling the rate of transcription and translation of Rubisco transgenes effectively in higher-plant plastids. Genetic transformation of the circular genome of the plastids provides a containable means for modifying plant growth by manipulating photosynthesis. Although the transformation mechanism is precise, predicting the level of foreign gene expression is difficult because the amounts of messenger RNA and protein produced by foreign genes in plastids varies widely, even when the protein assembles without difficulty. This project will devise strategies for controlling this variability that will facilitate attempts to exploit plastid transformation for transplanting better versions of the photosynthetic CO2-fixing enzyme, Rubisco, into plants to improve their growth efficiency in terms of water, fertiliser and light use.Read moreRead less
Dual-ion electrochemical systems. The project aims to develop dual-ion electrochemical systems. In contrast to conventional single-ion rechargeable cells, the charge storage process in the cathodes of these devices is facilitated by a second, negative ion. Dual-ion systems represent robust alternatives to current lithium-ion batteries and lithium-ion capacitors, addressing their sustainability and energy density limitations. The project’s outcomes are in the form of new sustainable energy storag ....Dual-ion electrochemical systems. The project aims to develop dual-ion electrochemical systems. In contrast to conventional single-ion rechargeable cells, the charge storage process in the cathodes of these devices is facilitated by a second, negative ion. Dual-ion systems represent robust alternatives to current lithium-ion batteries and lithium-ion capacitors, addressing their sustainability and energy density limitations. The project’s outcomes are in the form of new sustainable energy storage technologies with attrative energy and power densities for a wide range of applications. This should provide a significant benefit to society, the economy and the environment in enabling an easier transition to clean energy and ensuring energy security in Australia.Read moreRead less
Practical strategies for engineering the CO2-fixing enzyme, Rubisco, whose subunits are encoded in different subcellular compartments. My recent replacement of the plant CO2-fixing enzyme, Rubisco, with a less efficient bacterial version, with a single type of subunit encoded by a single gene, demonstrated the feasibility of replacing Rubisco. This encourages ongoing attempts to replace plant Rubisco with more efficient versions that would allow the plants to grow with less water, fertiliser or ....Practical strategies for engineering the CO2-fixing enzyme, Rubisco, whose subunits are encoded in different subcellular compartments. My recent replacement of the plant CO2-fixing enzyme, Rubisco, with a less efficient bacterial version, with a single type of subunit encoded by a single gene, demonstrated the feasibility of replacing Rubisco. This encourages ongoing attempts to replace plant Rubisco with more efficient versions that would allow the plants to grow with less water, fertiliser or light. The most efficient Rubiscos are more complex, with two different types of subunits which, in plants, are encoded in different subcellular compartments (nucleus and plastid). This proposal addresses the challenges associated with complementary engineering both genomes to substitute foreign Rubiscos into higher-plant chloroplasts.Read moreRead less
When Your Face is Your ID: Public Responses to Automated Facial Recognition. This project would explore public attitudes toward the use of facial recognition technology in public and commercial spaces, schools, and workplaces with a national survey, focus group interviews, and four case studies. The project aims to generate new knowledge about public attitudes through a multi-method interdisciplinary approach that anticipates the future of the technology by studying its use in China. Expected ou ....When Your Face is Your ID: Public Responses to Automated Facial Recognition. This project would explore public attitudes toward the use of facial recognition technology in public and commercial spaces, schools, and workplaces with a national survey, focus group interviews, and four case studies. The project aims to generate new knowledge about public attitudes through a multi-method interdisciplinary approach that anticipates the future of the technology by studying its use in China. Expected outcomes include public reports on the survey and case studies, seven academic journal articles, and a book. The research would provide significant benefits by contributing new knowledge about how to implement the technology in accordance with Australian commitments to civil rights, ethics and democratic values.
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Active Sound Control and Noise Cancellation over Space. This project aims to address the critical issues for creating acoustic quiet zones in a noisy environment. It will provide novel signal processing theory for further development of active noise cancellation techniques over spatial regions. New technologies developed from this project are expected to underpin the future development of acoustic signal processing research and will have a broad range of applications such as reduction of noise i ....Active Sound Control and Noise Cancellation over Space. This project aims to address the critical issues for creating acoustic quiet zones in a noisy environment. It will provide novel signal processing theory for further development of active noise cancellation techniques over spatial regions. New technologies developed from this project are expected to underpin the future development of acoustic signal processing research and will have a broad range of applications such as reduction of noise inside cars, creation of individual quiet zones in passenger planes and mitigation of acoustic noise made by industrial plants to neighbouring suburbs. The outcomes from this proposal will also have economic importance as it can reduce the health risk posed to people working or living in noisy environments.Read moreRead less