Development Of Microscope-in-a-needle Devices For Improved Clinical Diagnostics
Funder
National Health and Medical Research Council
Funding Amount
$327,746.00
Summary
We have developed a new high-resolution optical imaging technology. The unique aspect of our research has been to redesign the imaging probe, miniaturising it to a few hundred microns in diameter, and encase it in a hypodermic needle – a ‘microscope-in-a-needle’. We are developing specific imaging probes to aid in the assessment of lung disease; the diagnosis of liver disease; and integrated into a brain biopsy needle to enable safer brain biopsies.
Developing Interpretable Machine Learning Models For Clinical Imaging And Single-cell Genomics
Funder
National Health and Medical Research Council
Funding Amount
$1,312,250.00
Summary
Machine learning methods will be vital to make best use of the deluge of data generated by high-throughput technologies in biomedical science. To get the most out of these models, however, we need to be able to unpack the 'black box'. I will use curated clinical and public research data to benchmark and develop interpretable deep learning models and software tools. These models will be used for breast cancer screening programs and for analysis of complex, large-scale single-cell genomics data.
Aspirin For The Prevention Of Cognitive Decline In The Elderly: A Neuro-Vascular Imaging Study (ENVIS-ion) From ASPREE
Funder
National Health and Medical Research Council
Funding Amount
$1,341,232.00
Summary
The ENVIS-ion trial will examine whether Aspirin is effective in delaying the onset of worsening of thinking and memory abilities in healthy older adults. Magnetic resonance imaging (MRI) of brain structure will detect markers of early worsening of thinking and memory abilities. Blood vessels in the back of the eye (retina) share many features with vessels in the brain. We will compare whether aspirin lessens changes over time of features shown with brain MRI and retinal photography.
Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are inn ....Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are innovative semi-automated nephron visualisation and quantitation tools that enable efficient renal phenotyping. Techniques tailored to widely accessible preclinical research scanners are expected to accelerate research into genetic and environmental factors affecting kidney microstructure in embryonic and post-natal life.Read moreRead less
The Role Of Intense Physical Activity In Protecting The Ageing Brain
Funder
National Health and Medical Research Council
Funding Amount
$600,079.00
Summary
Previous research supports the notion that physical activity plays a role in maintaining brain health and preventing Alzheimer’s disease. Nevertheless, the type of activity (i.e. intensity of physical activity) that is of greatest benefit to the brain is yet to be established. This project aims to identify the most beneficial exercise intensity, in terms of brain health, measured utilising brain imaging technology.
Elastic and biodegradable sponges/aerogels from exfoliated silk nanofibres . The aim of this project is to investigate methods to produce highly porous elastic sponges from silk protein nanofibres. These sponges will have optimal mechanical, insulation and degradation properties making them suitable for a wide range of applications including the biomedical and personal care sectors, where current products have significant drawbacks due to the use of non-biodegradable synthetic materials. Outco ....Elastic and biodegradable sponges/aerogels from exfoliated silk nanofibres . The aim of this project is to investigate methods to produce highly porous elastic sponges from silk protein nanofibres. These sponges will have optimal mechanical, insulation and degradation properties making them suitable for a wide range of applications including the biomedical and personal care sectors, where current products have significant drawbacks due to the use of non-biodegradable synthetic materials. Outcomes include new knowledge on controlling porous structures and tailoring properties to targeted applications. This project, by laying the groundwork for a new generation of bio-based materials, will benefit the Australian advanced manufacturing sector, and enhance Australia's standing in materials science and engineering.Read moreRead less
Use of Gas Expanded Liquids to Facilitate Process Intensification. The aim of this research is the utilisation of gas expanded liquids (GXLs) in technology platforms based on the principles of process intensification (PI). In order to facilitate the attainment of project objectives a comprehensive investigation of the fundamental properties of GXLs, and their interactions is proposed. A significant component of the programme is expected to be to use the knowledge obtained to facilitate the devel ....Use of Gas Expanded Liquids to Facilitate Process Intensification. The aim of this research is the utilisation of gas expanded liquids (GXLs) in technology platforms based on the principles of process intensification (PI). In order to facilitate the attainment of project objectives a comprehensive investigation of the fundamental properties of GXLs, and their interactions is proposed. A significant component of the programme is expected to be to use the knowledge obtained to facilitate the development of scale-up protocol for PI based methodologies, with particular emphasis on the production of biomaterials. GXLs technology is frontier technology with regard to the biomaterials sector.Read moreRead less
Extending Leadership and Learning: Improving the effectiveness of new learning technology for culture change and improved regional business performance. This research project explores the complex relationships between new technology and learning, and the subsequent impact on organisational change and business effectiveness. The study will examine the use of video-conferencing and on-line training packages in the regional locations of a major bank, in order to determine more effective configurati ....Extending Leadership and Learning: Improving the effectiveness of new learning technology for culture change and improved regional business performance. This research project explores the complex relationships between new technology and learning, and the subsequent impact on organisational change and business effectiveness. The study will examine the use of video-conferencing and on-line training packages in the regional locations of a major bank, in order to determine more effective configurations of learning architecture that support organisational culture change and impact on business performance. The organisation has a strategic commitment to cultural change towards leadership and learning. This research intends to examine how new learning technologies can more effectively impact on achieving such cultural change and improved regional equity.Read moreRead less
Designing Bandwidth-Efficient High-Speed Underwater Acoustic Communication Systems with Block-by-Block Turbo Processing. Australia has one of the largest exclusive economic zones in the world, and it is vitally important for Australia to understand and benefit from the oceans. This project will give new perspectives in developing underwater acoustic communications that are important for marine industries and scientific research in areas such as the exploration and exploitation of offshore oil an ....Designing Bandwidth-Efficient High-Speed Underwater Acoustic Communication Systems with Block-by-Block Turbo Processing. Australia has one of the largest exclusive economic zones in the world, and it is vitally important for Australia to understand and benefit from the oceans. This project will give new perspectives in developing underwater acoustic communications that are important for marine industries and scientific research in areas such as the exploration and exploitation of offshore oil and gas, and ocean environment and climate monitoring. This project will lift the international profile of Australia in underwater acoustic communications research and, through the training of early career researchers and PhD students, this project will also develop a skills base for Australia in underwater acoustic communications.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH130200025
Funder
Australian Research Council
Funding Amount
$2,181,756.00
Summary
ARC Research Hub for transforming waste directly in cost-effective green manufacturing. ARC Research Hub for transforming waste directly in cost-effective green manufacturing. This Research Hub aims to create a unique opportunity for completely different industries to come together, with a common goal of creating value from mixed plastic and glass waste in manufacturing. Starting with fundamental investigations of the transformation behaviour of waste materials under high temperature conditions, ....ARC Research Hub for transforming waste directly in cost-effective green manufacturing. ARC Research Hub for transforming waste directly in cost-effective green manufacturing. This Research Hub aims to create a unique opportunity for completely different industries to come together, with a common goal of creating value from mixed plastic and glass waste in manufacturing. Starting with fundamental investigations of the transformation behaviour of waste materials under high temperature conditions, the hub will focus on developing scalable solutions for its manufacturing partners towards reducing the consumption of primary resources while simultaneously diverting waste streams from landfill. Additionally, the potential of using such transformations to yield improved products such as wear-resistant grinding media and light-weight building materials will be investigated to enhance Australian manufacturing.Read moreRead less