From economic benefit to social cost: Antecedents of irresponsible gambling. The social impact of gambling is a challenge for policy-makers. Australia's gambling expenditure in 2001 contributed $4.4 billion in tax revenue. This economic benefit however, is offset by significant social costs ($1.8 to $5.6 billion). We will identify when and how distorted memory for previous gambling outcomes and gaming machine accessibility can cause irresponsible gambling. The results can be used to make informe ....From economic benefit to social cost: Antecedents of irresponsible gambling. The social impact of gambling is a challenge for policy-makers. Australia's gambling expenditure in 2001 contributed $4.4 billion in tax revenue. This economic benefit however, is offset by significant social costs ($1.8 to $5.6 billion). We will identify when and how distorted memory for previous gambling outcomes and gaming machine accessibility can cause irresponsible gambling. The results can be used to make informed assessments of the social impact of increasing the accessibility of gambling opportunities on local communities. The results can also be used to understand how gambling that contributes to the economy of a community becomes a social cost.Read moreRead less
Executive functioning, gender, age and medication as predictors of developmental well-being among students with ADHD. This study constructs social-cognitive phenotypes of ADHD, evaluates mental health and investigates ADHD student perceptions of classroom environment and achievement in science as functions of executive functioning, gender, age and medication. The effect of standard psychostimulant intervention and a novel nonpsychostimulant option on executive function, developmental and educati ....Executive functioning, gender, age and medication as predictors of developmental well-being among students with ADHD. This study constructs social-cognitive phenotypes of ADHD, evaluates mental health and investigates ADHD student perceptions of classroom environment and achievement in science as functions of executive functioning, gender, age and medication. The effect of standard psychostimulant intervention and a novel nonpsychostimulant option on executive function, developmental and educational outcomes will be investigated. The expected outcomes will inform more effective teacher professional development, and reduce school problems associated with psychostimulant medication and its illicit distribution by students. The linkage of health and education partners meets a nationally identified need for more effective collaboration to improve education outcomes for ADHD students.Read moreRead less
Mechanism of action of an anti-inflammatory compound which targets alternatively activated macrophages. The project will study the mechanism by which a novel anti-inflammatory compound, developed by our commercial partner, suppresses the activity of a population of cells known as alternatively activated macrophages. These cells play a key role in driving allergic inflammation, including the inflammation associated with asthma.
Identification of novel markers of inflammation. This project will benefit Australia as it will increase basic understanding of inflammatory processes, result in a new generation of diagnostics for inflammatory diseases that could lead to earlier diagnosis and to monitor treatment, resulting in large economic and health benefit. It may lead to development of novel new therapies using monoclonal antibodies to regulate processes in immune, cardiovascular and infectious diseases. The work will gene ....Identification of novel markers of inflammation. This project will benefit Australia as it will increase basic understanding of inflammatory processes, result in a new generation of diagnostics for inflammatory diseases that could lead to earlier diagnosis and to monitor treatment, resulting in large economic and health benefit. It may lead to development of novel new therapies using monoclonal antibodies to regulate processes in immune, cardiovascular and infectious diseases. The work will generate significant economic spin-offs to the Australian biotechnology industry and will further relationships and training between research and development.Read moreRead less
NOVEL THERAPEUTICS FOR AUTOIMMUNE DISEASE USING MOUSE SCREENING MODELS. The project aims to use experimental models of human autoimmune disease in the mouse for the testing of developmental isoflavonoid compounds produced by the Industry Partner, for protective effects against autoimmunity. The murine models proposed will duplicate human autoimmune cardiomyopathy, systemic lupus erythematosus and multiple sclerosis, encompassing both organ-specific and systemic autoimmune diseases. Isoflavonoi ....NOVEL THERAPEUTICS FOR AUTOIMMUNE DISEASE USING MOUSE SCREENING MODELS. The project aims to use experimental models of human autoimmune disease in the mouse for the testing of developmental isoflavonoid compounds produced by the Industry Partner, for protective effects against autoimmunity. The murine models proposed will duplicate human autoimmune cardiomyopathy, systemic lupus erythematosus and multiple sclerosis, encompassing both organ-specific and systemic autoimmune diseases. Isoflavonoid protection is anticipated from the antioxidant, anti-inflammatory and oestrogenic characteristics of these compounds/Read moreRead less
Training for Adaptability: The role of errors, exceptions and rules of thumb. This project involving collaboration among three fire services across two states and two universities aims to develop theoretical and evidenced-based error and exceptions training in the prediction of fire behaviour among novices and experts. The project will advance significantly our understanding of ways of adapting knowledge and updating and improving rules of thumb for complex decision-making. An innovative new cri ....Training for Adaptability: The role of errors, exceptions and rules of thumb. This project involving collaboration among three fire services across two states and two universities aims to develop theoretical and evidenced-based error and exceptions training in the prediction of fire behaviour among novices and experts. The project will advance significantly our understanding of ways of adapting knowledge and updating and improving rules of thumb for complex decision-making. An innovative new critical incident recording system will be developed that identifies the cognitive determinants of errors. Tightly controlled laboratory studies will be combined with field studies leading to improved theoretical understanding as well as practical outcomes for the fire services.Read moreRead less
Towards a high density silicon phase change memory device. This project builds upon our exciting recent findings that amorphous silicon can be transformed to a conducting crystalline phase following small-scale indentation. Furthermore the process is reversible as re-indentation can induce a transformation back to insulating amorphous silicon. This process appears to occur in extremely small (nanoscale) volumes of silicon. We plan to explore the viability of exploiting this behaviour to develo ....Towards a high density silicon phase change memory device. This project builds upon our exciting recent findings that amorphous silicon can be transformed to a conducting crystalline phase following small-scale indentation. Furthermore the process is reversible as re-indentation can induce a transformation back to insulating amorphous silicon. This process appears to occur in extremely small (nanoscale) volumes of silicon. We plan to explore the viability of exploiting this behaviour to develop an entirely new information storage system: a high-density silicon phase change memory. This project aims to study small-scale transformation behaviour in silicon and to design demonstrator memory devices based on both micro-electromechanical systems and solid state technologies.Read moreRead less
Novel lipid-based adjuvants for induction of mucosal immunity. The project will determine if needle-free oral and transcutaneous immunisation using LipoVax, a novel lipid-based antigen delivery system developed by the industry partner, can protect mice against the mucosal pathogens Chlamydia and Helicobacter. We expect to show that this immunisation method can induce protective mucosal immunity against two of the most common infectious organisms affecting mankind. If successful this will allow u ....Novel lipid-based adjuvants for induction of mucosal immunity. The project will determine if needle-free oral and transcutaneous immunisation using LipoVax, a novel lipid-based antigen delivery system developed by the industry partner, can protect mice against the mucosal pathogens Chlamydia and Helicobacter. We expect to show that this immunisation method can induce protective mucosal immunity against two of the most common infectious organisms affecting mankind. If successful this will allow us to develop LipoVax as a new platform technology that can be applied to the development of human vaccines, veterinary vaccines, vaccines for companion animals and vaccines to target infections in feral animals and native wildlife population populations.Read moreRead less
Characterisation of nanobubbles. Surprisingly, nano-sized bubbles have recently been found to exist in aqueous solutions. Classical theory tells us they should rapidly dissolve, yet they are stable for several days, a phenomenon which has only recently been explained. Despite this, nanobubbles are already used in cleaning processes and appear to have significant health benefits. They are being investigated in treatments for asthma and neurodegenerative diseases. In collaboration with a pharmaceu ....Characterisation of nanobubbles. Surprisingly, nano-sized bubbles have recently been found to exist in aqueous solutions. Classical theory tells us they should rapidly dissolve, yet they are stable for several days, a phenomenon which has only recently been explained. Despite this, nanobubbles are already used in cleaning processes and appear to have significant health benefits. They are being investigated in treatments for asthma and neurodegenerative diseases. In collaboration with a pharmaceutical company, the best means to produce and characterise nanobubbles will be investigated, as well as the conditions governing their stability. The project also aims to determine how the nanobubbles interact with surfaces in order to better control their properties and achieve a better understanding of these bubbles.Read moreRead less
Determination of the mechanisms of immune system regulation of inflammation by the human protein, chaperonin 10. The aim of this project is to determine the mechanisms by which a human protein, chaperonin 10 (Cpn10), regulates the immune system and suppresses inflammation. When cells of the human immune system are challenged with lipopolysaccharide (LPS) (a product of bacterial infection), the pro-inflammatory cytokine TNF is released. Cpn10 has been shown to suppress production of TNF on chall ....Determination of the mechanisms of immune system regulation of inflammation by the human protein, chaperonin 10. The aim of this project is to determine the mechanisms by which a human protein, chaperonin 10 (Cpn10), regulates the immune system and suppresses inflammation. When cells of the human immune system are challenged with lipopolysaccharide (LPS) (a product of bacterial infection), the pro-inflammatory cytokine TNF is released. Cpn10 has been shown to suppress production of TNF on challenge of cells with LPS, while increasing the levels of the anti-inflammatory cytokine IL-10. Investigating the role of Cpn10 in modulating inflammation will contribute to the understanding and treatment of diseases associated with inflammation, including multiple sclerosis and rheumatoid arthritis.Read moreRead less