Development of purified antibodies that kill virus infected cells. This proposal will develop panels of purified and monoclonal antibodies that kill virus infected cells. These antibodies may show efficacy in preventing HIV infection. This is new technology that could subsequently be harnessed to protect or limit the devastating effects of chronic viruses such as HIV.
Enhancing immunogenicity of DNA vaccines by targeted delivery to antigen presenting cells. Vaccines have proven to be one of the most effective means of preventing infection and also provide promise as a treatment for cancer. However, the range of effective technologies that make possible the delivery of vaccines that can protect against a broad range of infections is limited. DNA based vaccines are attractive because they are relatively easy to produce against a wide range of infections. Howeve ....Enhancing immunogenicity of DNA vaccines by targeted delivery to antigen presenting cells. Vaccines have proven to be one of the most effective means of preventing infection and also provide promise as a treatment for cancer. However, the range of effective technologies that make possible the delivery of vaccines that can protect against a broad range of infections is limited. DNA based vaccines are attractive because they are relatively easy to produce against a wide range of infections. However, DNA vaccines often provide poor protection against infections. This project will explore a unique technology developed in Australia and that will greatly improve the effectiveness of DNA vaccines against a broad range of diseases. Read moreRead less
The measurement and prediction of police interviewing performance and the dissemination of good practice through a distributive workplace learning system. This research aims to develop the first ever standardised measures of police interviewers' performance, focusing on interviews about sexual offences. Standardised measures are essential for quality control evaluation, identifying training needs, assigning workload, predicting case outcome and benchmarking organisation capabilities. By improvin ....The measurement and prediction of police interviewing performance and the dissemination of good practice through a distributive workplace learning system. This research aims to develop the first ever standardised measures of police interviewers' performance, focusing on interviews about sexual offences. Standardised measures are essential for quality control evaluation, identifying training needs, assigning workload, predicting case outcome and benchmarking organisation capabilities. By improving the quality of police interviews about sexual offences, this research will improve the reporting, prosecution and conviction rates of sexual offences, which will have a deterrent effect on potential offenders. Further, this research will reduce the stress of witnesses and suspects involved in the legal process and reduce burnout of police interviewers by increasing competency and job satisfaction.Read moreRead less
Characterisation of nanobubbles. Surprisingly, nano-sized bubbles have recently been found to exist in aqueous solutions. Classical theory tells us they should rapidly dissolve, yet they are stable for several days, a phenomenon which has only recently been explained. Despite this, nanobubbles are already used in cleaning processes and appear to have significant health benefits. They are being investigated in treatments for asthma and neurodegenerative diseases. In collaboration with a pharmaceu ....Characterisation of nanobubbles. Surprisingly, nano-sized bubbles have recently been found to exist in aqueous solutions. Classical theory tells us they should rapidly dissolve, yet they are stable for several days, a phenomenon which has only recently been explained. Despite this, nanobubbles are already used in cleaning processes and appear to have significant health benefits. They are being investigated in treatments for asthma and neurodegenerative diseases. In collaboration with a pharmaceutical company, the best means to produce and characterise nanobubbles will be investigated, as well as the conditions governing their stability. The project also aims to determine how the nanobubbles interact with surfaces in order to better control their properties and achieve a better understanding of these bubbles.Read moreRead less
A longitudinal study of language learning to assess early intervention outcomes in pre-school children with impaired hearing. Overseas research suggests that young children with impaired hearing and normal non-verbal cognition can develop normal language if hearing aid fitting and intervention occur before 6 months of age. Australian studies show considerable language delays in most hearing-impaired children of primary-school age. We will study the spoken language learning of hearing-impaired ....A longitudinal study of language learning to assess early intervention outcomes in pre-school children with impaired hearing. Overseas research suggests that young children with impaired hearing and normal non-verbal cognition can develop normal language if hearing aid fitting and intervention occur before 6 months of age. Australian studies show considerable language delays in most hearing-impaired children of primary-school age. We will study the spoken language learning of hearing-impaired children up to age 6 years in Victoria. The project will investigate crucial factors in achieving normal language learning in hard-of-hearing children and the role of early intervention. Normal language outcomes would enhance the educational and career prospects of hearing-impaired children and result in community cost savings.
Read moreRead less
Rational structure-based drug design of protein tyrosine kinase inhibitors. Protein tyrosine kinases (PTK) are a large, pivotal family of signalling molecules implicated in diseases such as cancer and immune-related disorders, that cause significant morbidity and mortality within the population. This research proposal aims to develop PTK-specific small molecule inhibitors to combat such diseases. Cytopia's drug discovery capability, coupled with the X-ray crystallographic expertise within Monas ....Rational structure-based drug design of protein tyrosine kinase inhibitors. Protein tyrosine kinases (PTK) are a large, pivotal family of signalling molecules implicated in diseases such as cancer and immune-related disorders, that cause significant morbidity and mortality within the population. This research proposal aims to develop PTK-specific small molecule inhibitors to combat such diseases. Cytopia's drug discovery capability, coupled with the X-ray crystallographic expertise within Monash University, will permit a rational, structure-based drug discovery platform to be established. The ultimate goal of this innovative and mutlidisciplinary approach, namely a portfolio of phase I therapeutics, will be of substantial benefit in the medical health area.Read moreRead less
Rational structure-based drug design of protein tyrosine kinase inhibitors. This research project is focussed on understanding the physiological roles of a group of enzymes within the cell, as well as developing therapeutics to combat significant diseases. It will achieve this by developing compounds to enzymes that are implicated in the disease process. The research project represents a continuation of a collaboration between academic researchers at Monash University, and an Australian biotec ....Rational structure-based drug design of protein tyrosine kinase inhibitors. This research project is focussed on understanding the physiological roles of a group of enzymes within the cell, as well as developing therapeutics to combat significant diseases. It will achieve this by developing compounds to enzymes that are implicated in the disease process. The research project represents a continuation of a collaboration between academic researchers at Monash University, and an Australian biotechnology company, Cytopia Ltd.Read moreRead less
Improving the competency of police officers in conducting investigative interviews of children. The current research program aims to identify factors that promote and sustain competent police interviewing of children. Although 'best-practice' guidelines in investigative interviewing have been developed, these guidelines are under-utilised by police officers in practice. Research is therefore needed to identify barriers to the implementation of these 'best-practice' guidelines and to test interve ....Improving the competency of police officers in conducting investigative interviews of children. The current research program aims to identify factors that promote and sustain competent police interviewing of children. Although 'best-practice' guidelines in investigative interviewing have been developed, these guidelines are under-utilised by police officers in practice. Research is therefore needed to identify barriers to the implementation of these 'best-practice' guidelines and to test interventions designed to improve their uptake. The expected outcome of this project is the development of interventions that will improve the quality of police training in investigative interviewing. This will increase the quality of evidence obtained from children, especially those who are victims of child abuse.Read moreRead less
A Regional Perspective on Work & Family Balance and Changes in Employment Regulation. Work/family balance is a focus of significant attention at the community, national and international level. This project will generate new knowledge about the ways in which employment regulation directly and indirectly impacts on employee work/family balance outcomes within different regional and industry contexts. A growing body of research recognises the linkages between employment regulation and effects on c ....A Regional Perspective on Work & Family Balance and Changes in Employment Regulation. Work/family balance is a focus of significant attention at the community, national and international level. This project will generate new knowledge about the ways in which employment regulation directly and indirectly impacts on employee work/family balance outcomes within different regional and industry contexts. A growing body of research recognises the linkages between employment regulation and effects on child and parent well-being and health, labour force supply and economic outcomes. However, little is known about how geographical location shapes work/family balance. The research will thus contribute to improved understandings and to better social policy at the local, state and federal levels.Read moreRead less
Investigating the atomic structure of an immune cell inhibitory receptor. T cells play a key role in the adaptive immune system, whose reactivity must be controlled to prevent aberrant reactivity. Central to the function of T cells is the T cell antigen receptor, and a host of co-stimulatory molecules, co-receptors and inhibitory receptors. This proposal, in partnership with Immutep Ltd, aims to gain a basic understanding of the structure and function of a key inhibitory receptor found on T cel ....Investigating the atomic structure of an immune cell inhibitory receptor. T cells play a key role in the adaptive immune system, whose reactivity must be controlled to prevent aberrant reactivity. Central to the function of T cells is the T cell antigen receptor, and a host of co-stimulatory molecules, co-receptors and inhibitory receptors. This proposal, in partnership with Immutep Ltd, aims to gain a basic understanding of the structure and function of a key inhibitory receptor found on T cells, termed the Lymphocyte activation gene-3 (LAG-3). The proposal utilises a combination of cellular immunology and structural biology to gain insight into the form and function of the LAG-3 molecule. Ultimately this fundamental knowledge can be used by the biotechnology industry.Read moreRead less