The Relationship Between Maternal And Infant Dietary Intake Of Fermentable Fibre, Gut Microbiota, Short Chain Fatty Acids And Allergic Disease And Asthma: A Population-derived Birth Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$871,700.00
Summary
The proposed study will involve the Barwon Infant Study (BIS) cohort of 1074 infants to provide the first systematic investigation of the hypotheses that the epidemic of allergic disease and asthma in many parts of the world relates to the paucity of fermentable fibre in the modern diet, and that the protective effect of fermentable fibre is mediated by changes in the organisms that colonise the gut and the metabolites that they produce.
Understanding The Role Of The Putative Phospholipid Translocase ATP11c In B Cell Development
Funder
National Health and Medical Research Council
Funding Amount
$455,153.00
Summary
The immune system protects humans against recurrent infections with a wide range of pathogens. Formation of antibodies is a crucial element of the immune response. Defects in the production of antibodies can lead to recurrent and often life-threatening infections. This project seeks to understand a genetic defect in mice resulting in an almost complete absence of antibody producing cells, thereby causing a disease that is similar to some forms of human immunodeficiency.
A Population-based Cohort Investigation Of Postnatal Microbial Experience, Immune Programming And Allergic Disease Risk
Funder
National Health and Medical Research Council
Funding Amount
$1,511,471.00
Summary
This is a population-based longitudinal investigation of the early life host-environment interactions that influence development of the immune system, and the risk of allergic disease. Importantly, this is one of the first studies designed to examine epigenetic programming of the infant immune system in the population setting. Thus we will be able to conduct robust tests of several critical hypotheses that will inform the prevention of allergic disease.
A socio-ecological comparison of nations making a transition to renewable energy. This project aims to use ethnography to investigate how legitimacy for renewable energy can be won or lost. The project will focus on Germany, India and Australia, regions that are undergoing ‘energy transition.’ It, conducts in-depth studies of changing socio-ecological relations, theorising through comparative analysis, and creating new data on the socio-cultural forces for emission reduction. The project will an ....A socio-ecological comparison of nations making a transition to renewable energy. This project aims to use ethnography to investigate how legitimacy for renewable energy can be won or lost. The project will focus on Germany, India and Australia, regions that are undergoing ‘energy transition.’ It, conducts in-depth studies of changing socio-ecological relations, theorising through comparative analysis, and creating new data on the socio-cultural forces for emission reduction. The project will analyse what can be done to enhance the transition to renewable energy. The expected outcomes are grounded in the comparative study of regions that are making a transition to renewable power.Read moreRead less
'Digital Natives': Growing up with new and old media in Australia. Developing a sophisticated digital literacy is important for both the future of children, the cultural, social and economic well-being of the nation. Digital literacy requires not only communications infrastructure but targeted investment in human skills. Investing in the development of a digitally literate Australian population has become an explicit means for promoting the future economic and social well-being of the nation. Th ....'Digital Natives': Growing up with new and old media in Australia. Developing a sophisticated digital literacy is important for both the future of children, the cultural, social and economic well-being of the nation. Digital literacy requires not only communications infrastructure but targeted investment in human skills. Investing in the development of a digitally literate Australian population has become an explicit means for promoting the future economic and social well-being of the nation. The information provided by this project has the potential to contribute significantly to giving children 'a healthy start to life' in their early years. Read moreRead less
Discovering genes and mechanisms regulating immune responses. The Fellowship will retain and expand a pioneering Australian research program, and attract to Australia major international investment and technology linkages, making use of the DNA sequence of humans and other mammals to advance understanding of immunity and infection control in public health, agriculture and industry. The program will build on Australia's pre-eminent research strengths in the field of immunity and infection, and w ....Discovering genes and mechanisms regulating immune responses. The Fellowship will retain and expand a pioneering Australian research program, and attract to Australia major international investment and technology linkages, making use of the DNA sequence of humans and other mammals to advance understanding of immunity and infection control in public health, agriculture and industry. The program will build on Australia's pre-eminent research strengths in the field of immunity and infection, and will create new knowledge and resources to improve human and animal health through vaccines, pharmaceuticals and public health policy. Read moreRead less
The vision we rely on every day to read and recognise faces depends upon the health of the central portion of our retina, the macula. Age-related Macular Degeneration (AMD) is the leading cause of blindness in Australia and the western world. Researchers at the Australian National University are collaborating to bring a new test for AMD severity to the market within 3 years. The objective is to provide doctors with a rapid, cost-effective tool to help them manage treatment.
Epigenetic Programming Of Immune Development In Utero: Role Of The Maternal Environment In The Allergy Epidemic
Funder
National Health and Medical Research Council
Funding Amount
$764,463.00
Summary
This study will provide new insights into the development of allergic disease. Specifically, we will explore the hypothesis that allergic disease and other disorders or immune dysregulation occur as a result of gene-environmental interactions in early life, and that these events begin in pregnancy when the developing fetus is still developing and most susceptible to these effects.
Energy transitions: past, present and future. Uncertainty about the costs of transitioning to a low carbon economy in Australia and other countries will be reduced by improving our knowledge of the costs of reducing fossil fuel use and the role of energy in economic growth. Energy economics research capabilities in Australia will be enhanced.
Observe, Reflect, Improve: a tool to enrich Children’s Learning (ORICL). This project aims to address long-standing concerns about the quality of education and care for children during their critical first two years. It will introduce a promising, future-focused digital tool, co-designed with practitioners and providers of early childhood services, to support infant-toddler educators’ planning and practice. Building on ground-breaking pilot work, we will undertake a national implementation and e ....Observe, Reflect, Improve: a tool to enrich Children’s Learning (ORICL). This project aims to address long-standing concerns about the quality of education and care for children during their critical first two years. It will introduce a promising, future-focused digital tool, co-designed with practitioners and providers of early childhood services, to support infant-toddler educators’ planning and practice. Building on ground-breaking pilot work, we will undertake a national implementation and evaluation of the Observe, Reflect and Improve Children’s Learning (ORICL) tool. Expected outcomes include: enhanced pedagogical practices; enriched learning experiences for children birth-two; effective communication with families; and improved resourcing for providers of early childhood education and care services. Read moreRead less