Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100001
Funder
Australian Research Council
Funding Amount
$875,000.00
Summary
A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected out ....A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected outcomes to include the generation of new knowledge of major biological systems, including the immune system and the nervous system. This will provide significant benefits to fundamental interdisciplinary research into immunology, infectious disease, neuroscience, mechanobiology and engineering.Read moreRead less
Electrical properties of human dendrites. This project aims to determine the electrical properties of dendrites in human neurons. Dendrites are the primary site of synaptic input to neurons and their electrical properties play a key role in information processing in the brain. While we know much about the electrical properties of dendrites in other species, primarily rodents, little is known about the electrical properties of human dendrites. This project aims to address this gap in knowledge fo ....Electrical properties of human dendrites. This project aims to determine the electrical properties of dendrites in human neurons. Dendrites are the primary site of synaptic input to neurons and their electrical properties play a key role in information processing in the brain. While we know much about the electrical properties of dendrites in other species, primarily rodents, little is known about the electrical properties of human dendrites. This project aims to address this gap in knowledge for the first time. The results obtained will shed light on the mechanisms the brain uses to process information, and therefore will bring us a step closer to truly understanding ourselves.Read moreRead less
Role of the superior colliculus in sensory processing. The ability of an organism to attend to, and orient towards, stimuli in the environment is critical for survival. In the mammalian brain, the principal brain region performing this function is the superior colliculus. Despite its importance, little is known about the role the superior colliculus plays in sensory perception. This project addresses this issue by leveraging revolutionary new recording techniques to determine how the superior co ....Role of the superior colliculus in sensory processing. The ability of an organism to attend to, and orient towards, stimuli in the environment is critical for survival. In the mammalian brain, the principal brain region performing this function is the superior colliculus. Despite its importance, little is known about the role the superior colliculus plays in sensory perception. This project addresses this issue by leveraging revolutionary new recording techniques to determine how the superior colliculus codes sensory information and ultimately drives behaviour. The outcomes will be of immediate benefit to scientists studying sensory processing and perceptual decision making, and will help keep Australia at the forefront of brain-inspired engineering and the neuroscience-based knowledge economy.Read moreRead less
Coding of olfactory information in the piriform cortex. This project aims to understand how electrical activity in the primary olfactory (piriform) cortex enables mice to recognise and remember odours. By using optical recording techniques together with genetic tools, the project expects to generate new knowledge about how the mammalian brain builds internal representations of the external world. Specific outcomes of the project include new insights into the functional architecture of the pirifo ....Coding of olfactory information in the piriform cortex. This project aims to understand how electrical activity in the primary olfactory (piriform) cortex enables mice to recognise and remember odours. By using optical recording techniques together with genetic tools, the project expects to generate new knowledge about how the mammalian brain builds internal representations of the external world. Specific outcomes of the project include new insights into the functional architecture of the piriform cortex and fresh understanding of how olfactory information is encoded and stored in neural circuits. More broadly, the project aims to advance our understanding of how the brain works, with benefits for future improvements in artificial intelligence and brain-machine interfaces.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100085
Funder
Australian Research Council
Funding Amount
$440,954.00
Summary
Forensic genomic toolkit for tracking the illegal wildlife trade. This project aims to analyse the illegal parrot trade by utilising conservation genomic approaches. The project will reveal wildlife trade routes in South-east Asia by developing cutting-edge forensic genomic techniques and criminological methods. Expected outcomes of this project include new field-deployable sequencing technology to provide in-situ genetic information for identifying the taxonomy and provenance of confiscated spe ....Forensic genomic toolkit for tracking the illegal wildlife trade. This project aims to analyse the illegal parrot trade by utilising conservation genomic approaches. The project will reveal wildlife trade routes in South-east Asia by developing cutting-edge forensic genomic techniques and criminological methods. Expected outcomes of this project include new field-deployable sequencing technology to provide in-situ genetic information for identifying the taxonomy and provenance of confiscated specimens, and a first ever genetic database of traded wildlife. The project will facilitate important countermeasures to the illegal wildlife trade including confiscation, reintroduction, improved law enforcement, and education for better biodiversity outcomes in our region.Read moreRead less
The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling f ....The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling for a synergistic defence to adapt to the nanoparticle toxicity. The pioneering knowledge is the foundation for technologies targeting the interspecies metabolite cross-talking to overcome the resistance phenomena, ensuring a long-term efficacy of the alternative antimicrobial on the difficult-to-control pathogenic growth.Read moreRead less
Counter-COVID public policies and the impacts on Australian children. This project aims to identify the causal effects of counter-COVID school closures, stay-at-home mandates and government support payments on the educational and developmental outcomes of Australian children. It will establish, for the first time, a comprehensive causal evidence base on the average and distributional impacts of these policies on children across the spectrum of schooling years from preschool to secondary school c ....Counter-COVID public policies and the impacts on Australian children. This project aims to identify the causal effects of counter-COVID school closures, stay-at-home mandates and government support payments on the educational and developmental outcomes of Australian children. It will establish, for the first time, a comprehensive causal evidence base on the average and distributional impacts of these policies on children across the spectrum of schooling years from preschool to secondary school completion. This project expects to advance our understanding of child skill accumulation and the relative importance of schools, parents, peers and government intervention. Anticipated benefits include providing policy recommendations to restore student learning outcomes and reduce educational inequality in Australia.Read moreRead less
Reducing health disparities for culturally and linguistically diverse peoples. This project aims to develop a greater understanding of migrants and the factors that predict poor health outcomes related to blood-borne viruses and sexually transmitted infections. The delayed access by migrants to healthcare from culturally and linguistically diverse backgrounds results in late diagnosis, low treatment uptake, and poorer health outcomes, with enhanced risk of infection and increased burden on the h ....Reducing health disparities for culturally and linguistically diverse peoples. This project aims to develop a greater understanding of migrants and the factors that predict poor health outcomes related to blood-borne viruses and sexually transmitted infections. The delayed access by migrants to healthcare from culturally and linguistically diverse backgrounds results in late diagnosis, low treatment uptake, and poorer health outcomes, with enhanced risk of infection and increased burden on the health system. The data collected in this project will assist in developing health services to meet these needs.Read moreRead less
Social, economic and health vulnerabilities in Indonesia. This project aims to study and provide ways to overcome vulnerability in Indonesia. Half the Indonesian population is still clustered around the poverty line, contributing to their vulnerability. This project will identify vulnerable groups and why they are vulnerable. Using a common framework of the life course in eight Indonesian field sites, this project will investigate whether social networks and welfare programs reduce vulnerability ....Social, economic and health vulnerabilities in Indonesia. This project aims to study and provide ways to overcome vulnerability in Indonesia. Half the Indonesian population is still clustered around the poverty line, contributing to their vulnerability. This project will identify vulnerable groups and why they are vulnerable. Using a common framework of the life course in eight Indonesian field sites, this project will investigate whether social networks and welfare programs reduce vulnerability, and pinpoint strategies for reducing vulnerabilities in the future. The project expects to show how vulnerable citizens in Indonesia can be made more secure, helping to build a more stable and prosperous region.Read moreRead less