Arbovirus Activation And Modulation Of NLRP3 Inflammasome
Funder
National Health and Medical Research Council
Funding Amount
$779,720.00
Summary
This project aims to establish how mosquito borne viruses such as Ross River and dengue viruses interacts with the human host to cause disease, including how the virus evades the host’s immune response to persist and cause disease for prolonged periods. Knowing how differences in the virus and the host’s immune system interplay to cause asymptomatic to severely disabling disease will assist in devising new treatments and prevention programs to lessen the impact of these diseases in Australia.
Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
Special Research Initiatives - Grant ID: SR0354575
Funder
Australian Research Council
Funding Amount
$30,000.00
Summary
Earth and Ocean Informatics and Technology Network (EON-ITnet). Sustainable resource exploration and mining onshore, as well as marine planning, exploration, and defence depend on effective cross-disciplinary investigation, sharing of expertise and technologies for integration and computational analysis of multidimensional data spaces. EON-ITNET will cross-fertilise the use of artificial intelligence, advanced computing and smart information sharing for management, analysis, visualisation and me ....Earth and Ocean Informatics and Technology Network (EON-ITnet). Sustainable resource exploration and mining onshore, as well as marine planning, exploration, and defence depend on effective cross-disciplinary investigation, sharing of expertise and technologies for integration and computational analysis of multidimensional data spaces. EON-ITNET will cross-fertilise the use of artificial intelligence, advanced computing and smart information sharing for management, analysis, visualisation and metadata modelling between these traditionally separate research groups, with the outcome of improving research efficiency and lowering costs. EON-ITNET will form an alliance with the Caltech-based GeoFramework, which is advancing a novel object-oriented data analysis environment, binding community software for Earth visualisation and simulation to 4D data bases.Read moreRead less
Special Research Initiatives - Grant ID: SR0354582
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Australia-NZ Network for Vegetation Function and Futures. Plants shape our landscapes and drive ecosystem processes from local to global scale. Plant species vary widely in quantitative functional traits. Global datasets about functional variation are emerging, with Australian and NZ leadership. A network would be supported in both Australia and NZ and with strong links elsewhere. It would target seven ambitious but achievable research developments. Each of them demands intensive conversation be ....Australia-NZ Network for Vegetation Function and Futures. Plants shape our landscapes and drive ecosystem processes from local to global scale. Plant species vary widely in quantitative functional traits. Global datasets about functional variation are emerging, with Australian and NZ leadership. A network would be supported in both Australia and NZ and with strong links elsewhere. It would target seven ambitious but achievable research developments. Each of them demands intensive conversation between separate disciplines. Networking across all seven strands will create a broader linkage, spanning across palaeobiology, ecosystem function, vegetation structure, global change, ecophysiology, phylogeny, genomics, ecoinformatics and evolutionary theory.Read moreRead less
Enhanced 3-D seismic structure for Southwest Australia. The ancient cratonic lithosphere of Southwest Australia appears to have a distinct contrast in geophysical properties and complex geologic structure, while having some of the highest levels of earthquakes on the continent. The project aims to produce novel 3-D models of this region that combine new seismic data collected over two years with previously collected geophysical datasets from the partner investigators. A compilation of 3-D models ....Enhanced 3-D seismic structure for Southwest Australia. The ancient cratonic lithosphere of Southwest Australia appears to have a distinct contrast in geophysical properties and complex geologic structure, while having some of the highest levels of earthquakes on the continent. The project aims to produce novel 3-D models of this region that combine new seismic data collected over two years with previously collected geophysical datasets from the partner investigators. A compilation of 3-D models will subsequently be developed, to form an effective characterisation of the geologic structure of the craton and its margins. These models will provide enhanced assessment of seismic ground shaking from regional earthquakes and facilitate an improved understanding of mineral resource potential. Read moreRead less
ARC Australia-New Zealand Research Network for Vegetation Function. Plant species vary widely in quantitative functional traits, and in their relations to climate, soils and geography. Global generalizations are emerging. Vegetation Function network will reach from plant function into genomics and crop breeding, into palaeoecology and vegetation history, into landscape management for carbon, water and salinity outcomes, into forecasting future ecosystems under global change, and into phylogeny, ....ARC Australia-New Zealand Research Network for Vegetation Function. Plant species vary widely in quantitative functional traits, and in their relations to climate, soils and geography. Global generalizations are emerging. Vegetation Function network will reach from plant function into genomics and crop breeding, into palaeoecology and vegetation history, into landscape management for carbon, water and salinity outcomes, into forecasting future ecosystems under global change, and into phylogeny, ecoinformatics and evolutionary theory. Across this span, working groups will target nine identified opportunities for breakthrough research. Each research target needs input from two or more disciplines. Together, the nine targets link across disciplines, as a network that spans from genomic to planetary scales.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC190100031
Funder
Australian Research Council
Funding Amount
$3,973,202.00
Summary
ARC Training Centre in Data Analytics for Resources and Environments (DARE). Understanding the cumulative impact of actions regarding the use of our resources has important long-term consequences for Australia’s economic, societal and environmental health. Yet despite the importance of these cumulative impacts, and the availability of data, many decisions and policies are based on limited amounts of data and rudimentary data analysis, with little appreciation of the critical role that understand ....ARC Training Centre in Data Analytics for Resources and Environments (DARE). Understanding the cumulative impact of actions regarding the use of our resources has important long-term consequences for Australia’s economic, societal and environmental health. Yet despite the importance of these cumulative impacts, and the availability of data, many decisions and policies are based on limited amounts of data and rudimentary data analysis, with little appreciation of the critical role that understanding and quantifying uncertainty plays in the process. The aim of Data Analytics in Resources and Environment (DARE) is to develop and deliver the data science skills and tools for Australia’s resource industries to make the best possible evidence-based decisions in exploiting and stewarding the nation’s natural resources.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH210100023
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Research Hub for Functional and Sustainable Fibres. This Research Hub aims to expand Australia’s position in fibres, textiles and composites by developing next generation functional fibre materials and creating synergy between functionality and sustainability, two key attributes that have hitherto been mutually exclusive. The Hub will transform regional and national economies from traditional manufacturing to a vibrant future fibre oriented advanced manufacturing sector with functionality an ....ARC Research Hub for Functional and Sustainable Fibres. This Research Hub aims to expand Australia’s position in fibres, textiles and composites by developing next generation functional fibre materials and creating synergy between functionality and sustainability, two key attributes that have hitherto been mutually exclusive. The Hub will transform regional and national economies from traditional manufacturing to a vibrant future fibre oriented advanced manufacturing sector with functionality and sustainability as central tenets. Expected outcomes include industry adoption of novel fibre-based materials, processing and recycling technologies; creating jobs, significant environmental benefits, and positioning Australia at the front of a global shift towards functional and sustainable materials.Read moreRead less
Optimising seed sourcing for effective ecological restoration. This project aims to address the sourcing of native seed for ecological restoration under global change. The great demand for native seed to deliver ecological restoration provides a clear need and responsibility to use this seed as efficiently as possible. This project expects to develop detailed new knowledge that links plant and environmental genomics, plant physiology, seed and soil biology in embedded experiments at post-mining ....Optimising seed sourcing for effective ecological restoration. This project aims to address the sourcing of native seed for ecological restoration under global change. The great demand for native seed to deliver ecological restoration provides a clear need and responsibility to use this seed as efficiently as possible. This project expects to develop detailed new knowledge that links plant and environmental genomics, plant physiology, seed and soil biology in embedded experiments at post-mining rehabilitation sites. Expected outcomes include clear industry guidelines that refine seed sourcing strategies for ecological restoration for current and future climates. This should provide significant benefits for improved ecological restoration outcomes when using native seed today and into the future.Read moreRead less