Antigen Presentation, Recognition And The Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$14,927,045.00
Summary
This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of techniques to dissect the function of various immune cell types and to explore the relationship between structure and function of important cell surface molecules. These studies will improve our ability to design new generation vaccines for combating infectious diseases, controlling cancer, or limiting autoimmune or inflammatory diseases.
Antigen Presentation, Recognition And The Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$15,780,848.00
Summary
This program focuses on understanding the development of immune response to viruses and other infectious agents using a broad array of techniques to dissect the function of various immune cell types and to explore the relationship between structure and function of important cell surface molecules. These studies will improve our ability to design new generation vaccines for combating infectious diseases, controlling cancer, or limiting autoimmune diseases like diabetes.
An Australian storm wave damage and beach erosion early warning system. This project aims to develop a new coastal hazard early-warning system capability for Australia, to alert coastal communities, emergency managers and coastal engineers to impending storm wave damage and coastal erosion. Emergency preparedness informed by early warning is expected to significantly benefit vulnerable communities and infrastructure along Australia’s coasts.
Optimising artificial reef structures for nature-based coastal protection . This project aims to develop a novel framework for predicting how artificial reef structures can be optimally designed to protect coastlines from erosion and flooding. It will develop new theory and models to quantify how waves interact with complex reef structures to reduce wave heights and extreme water levels at the shoreline. Expected outcomes include new practical tools and design guidelines that can be adopted by c ....Optimising artificial reef structures for nature-based coastal protection . This project aims to develop a novel framework for predicting how artificial reef structures can be optimally designed to protect coastlines from erosion and flooding. It will develop new theory and models to quantify how waves interact with complex reef structures to reduce wave heights and extreme water levels at the shoreline. Expected outcomes include new practical tools and design guidelines that can be adopted by coastal engineers and managers to maximise coastal protection by reefs. This will boost Australia’s capacity to protect populations and critical infrastructure from coastal hazards and support Australian industries to lead the international development of innovative nature-based coastal protection strategies.Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100498
Funder
Australian Research Council
Funding Amount
$470,550.00
Summary
Optimising bioengineered structures for resilient shorelines and habitats. Nature-based solutions for shoreline protection through ecosystem restoration are increasingly being considered by foreshore managers. However, habitat restoration efforts are greatly hampered by the time it takes to fully revegetate an area. This project aims to develop a comprehensive understanding of wave interaction with bioengineered structures that provide shelter from wave impacts and promote revegetation and contr ....Optimising bioengineered structures for resilient shorelines and habitats. Nature-based solutions for shoreline protection through ecosystem restoration are increasingly being considered by foreshore managers. However, habitat restoration efforts are greatly hampered by the time it takes to fully revegetate an area. This project aims to develop a comprehensive understanding of wave interaction with bioengineered structures that provide shelter from wave impacts and promote revegetation and contribute to shoreline flood and erosion mitigation. Expected outcomes of this project include quantitative design guidelines and predictive tools that will help foreshore managers to develop more robust and cost-effective nature-based shoreline protection strategies. Read moreRead less
A specialised set of T lymphocytes called Mucosal Associated Invariant T (MAIT) cells react against bacteria and yeast, and reside at mucosal sites where the body's immune defences are most easily breached, e.g. respiratory tract and intestinal mucosa. This study investigates the role of MAIT cells in both protection and pathology in bacterial infections. Controlling MAIT cells could help in treating these conditions.
Engineering screw piles to secure offshore wind energy turbines. This project aims to tackle the scientific challenges of using screw piles as foundations for deep water offshore wind turbines. Current foundations for offshore infrastructure developments have reached their limits, and conventional screw piles are designed for land use. This project will use innovative geotechnical methods to develop verified designs, guidelines and numerical tools for predicting the forces required to install sc ....Engineering screw piles to secure offshore wind energy turbines. This project aims to tackle the scientific challenges of using screw piles as foundations for deep water offshore wind turbines. Current foundations for offshore infrastructure developments have reached their limits, and conventional screw piles are designed for land use. This project will use innovative geotechnical methods to develop verified designs, guidelines and numerical tools for predicting the forces required to install screw piles into the seabed and their capacity to resist extreme wind and wave forces relevant to these structures. As foundations cost up to 35% of construction, screw piles will provide significant economic and environmental benefits in reducing costs and unlocking substantial renewable energy from our oceans.Read moreRead less
Unravelling The Mechanism Of MHC Class-I Associated Drug Hypersensitivities
Funder
National Health and Medical Research Council
Funding Amount
$566,308.00
Summary
Some drugs cause adverse reactions that are life threatening. We think these reactions are mediated by killer T cells as they are genetically controlled by immune response genes that normally guide immunity to microbes. We will study immune reactions to the drug abacavir, used to treat HIV (AIDS); allopurinol used to prevent gout and carbamazepine, used to treat epilepsy. The study may also help devise better treatments for patients who experience severe forms of these reactions.