SCALE-C: Strategies For Hepatitis C Testing And Treatment In Aboriginal Communities That Lead To Elimination
Funder
National Health and Medical Research Council
Funding Amount
$2,175,170.00
Summary
Prevalence of hepatitis C infection within the Aboriginal population is among the highest of any identifiable population in Australia. Highly effective, direct-acting antiviral (DAA) therapy, and their listing on the PBS in 2016 has revolutionised HCV clinical management in Australia. The SCALE-C study will evaluate an established test and treat model to rapidly scale-up DAA within four Aboriginal communities to determine both impact on community prevalence and ongoing transmission.
Just spaces: security without prejudice in the wireless courtroom. How do jurors respond to seeing defendants in a glass cage, in a traditional wooden dock or at the Bar table? The project will examine how courtroom design shapes attitudes; and, bringing together court executives, architects and researchers, will show how flexible wireless courtrooms can meet both security and human rights standards.
Imaging The Hepatitis C Virus Life Cycle In Real-time
Funder
National Health and Medical Research Council
Funding Amount
$477,504.00
Summary
Hepatitis C virus (HCV) is a serious viral pathogen that causes significant liver disease. This proposal plans to examine how two proteins from the HCV, core and NS5A, interact with host proteins and pathways to facilitate viral replication and release of HCV; two processes that are poorly understood. Specifically we will tag viral proteins to allow us to investigate the HCV life cycle in living cells and determine the role of core and NS5A in facilitating HCV replication. This proposal may unco ....Hepatitis C virus (HCV) is a serious viral pathogen that causes significant liver disease. This proposal plans to examine how two proteins from the HCV, core and NS5A, interact with host proteins and pathways to facilitate viral replication and release of HCV; two processes that are poorly understood. Specifically we will tag viral proteins to allow us to investigate the HCV life cycle in living cells and determine the role of core and NS5A in facilitating HCV replication. This proposal may uncover novel therapeutic strategies to combat HCV.Read moreRead less
The Ontogeny of Pain Behaviour: A Novel Neuroimmune Pathway. In Australia, 20% of the population report suffering from chronic pain. The cost of pain to Australian business per year is over $3 billion. Attempts to explain many chronic pain states, based on current knowledge, have failed. The central hypothesis of this project is that pain sensitivity is determined by programming of the fetal immune system during pregnancy. This research proposal will determine whether exposure to infection early ....The Ontogeny of Pain Behaviour: A Novel Neuroimmune Pathway. In Australia, 20% of the population report suffering from chronic pain. The cost of pain to Australian business per year is over $3 billion. Attempts to explain many chronic pain states, based on current knowledge, have failed. The central hypothesis of this project is that pain sensitivity is determined by programming of the fetal immune system during pregnancy. This research proposal will determine whether exposure to infection early in life determines sensitivity to pain in adult life. In doing so, this research offers a new theoretical explanation for the ontogeny of pain and may begin to account for the many forms of chronic pain that are currently not only unexplainable from current pain theory, but difficult to manage clinically.Read moreRead less
The Cambrian Population Explosion of Arthropods in Australia: Ediacaran origins, evolution and biodiversity. This project addresses key questions on the origin and diversification of life, by investigating the evolution of the most important fossil group (arthropods) across arguably the most important event after the origin of life (the Cambrian explosion of macroscopic life). It will also excavate, promote and conserve two key geological resources of national importance, in the Flinders Ranges ....The Cambrian Population Explosion of Arthropods in Australia: Ediacaran origins, evolution and biodiversity. This project addresses key questions on the origin and diversification of life, by investigating the evolution of the most important fossil group (arthropods) across arguably the most important event after the origin of life (the Cambrian explosion of macroscopic life). It will also excavate, promote and conserve two key geological resources of national importance, in the Flinders Ranges and Kangaroo Island. Also, it will lead to increased knowledge of the palaeoecology and geology of the economically-important Adelaide geosyncline, and benefit rural SA communities through ecotourism, a rural schools education program, and public outreach.Read moreRead less
How climate-resilient are our temperate fisheries species? This project assesses the resilience of our temperate fisheries species to climate change. Using natural warming hotspots and volcanic CO2 vents we study populations of fisheries species that are already pre-adapted to future climate, and therefore could act as key populations for replenishment of future fisheries stocks. An innovative and interdisciplinary approach combines the ecology, genetics, behaviour, and physiology of fisheries s ....How climate-resilient are our temperate fisheries species? This project assesses the resilience of our temperate fisheries species to climate change. Using natural warming hotspots and volcanic CO2 vents we study populations of fisheries species that are already pre-adapted to future climate, and therefore could act as key populations for replenishment of future fisheries stocks. An innovative and interdisciplinary approach combines the ecology, genetics, behaviour, and physiology of fisheries species to evaluate their climate resilience. An advanced food web model will be developed to forecast changes to fisheries production in a future world. This provides a much-improved forecast of climate adaptation and managing future biodiversity and fisheries species through resilient genes and populations.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100022
Funder
Australian Research Council
Funding Amount
$580,000.00
Summary
New frontier in Geoscience: A tandem trace element and isotopes facility. The project aims to integrate a multicollector mass spectrometer with the existing laser ablation laboratory at Southern Cross University to establish a unique facility offering tandem trace element and isotopes analysis. This will provide new methodological advancement by expanding the analytical range and obtaining information otherwise inaccessible to stand-alone instruments using traditional standardisation methods. Sp ....New frontier in Geoscience: A tandem trace element and isotopes facility. The project aims to integrate a multicollector mass spectrometer with the existing laser ablation laboratory at Southern Cross University to establish a unique facility offering tandem trace element and isotopes analysis. This will provide new methodological advancement by expanding the analytical range and obtaining information otherwise inaccessible to stand-alone instruments using traditional standardisation methods. Specifically, the integration of an innovative split stream system allows precise matching of elemental concentration with isotopic ratios, crucial for microscale resolution and data accuracy. The new infrastructure will confirm Australia’s leadership role and maintain its competitive advantage in geosciences.Read moreRead less
Improved management of coastal plankton systems by ancient DNA technology. This project aims to assemble comprehensive long term Australian plankton records spanning 50 to 1000 years, by applying ancient DNA technology to dated sediment depth cores. Long-term data for Australian coastal and estuarine waters are sparse, so cannot be used for management of fisheries, tourism or urban development. Long-term records are essential to understand how disruptive algal and jellyfish blooms, introduced sp ....Improved management of coastal plankton systems by ancient DNA technology. This project aims to assemble comprehensive long term Australian plankton records spanning 50 to 1000 years, by applying ancient DNA technology to dated sediment depth cores. Long-term data for Australian coastal and estuarine waters are sparse, so cannot be used for management of fisheries, tourism or urban development. Long-term records are essential to understand how disruptive algal and jellyfish blooms, introduced species and increased human use of coastal resources affect dynamic plankton ecosystems. This project’s findings are expected to explore cyclical patterns, define range expansions and understand and manage how dynamic coastal ecosystems respond to multistressor anthropogenic change. Findings will improve understanding of how dynamic marine environments retain their biodiversity values and critical ecological functions.Read moreRead less
Special Research Initiatives - Grant ID: SR0354734
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
The Australian Research Network for Medical Devices: advanced technology solutions for patients and practitioners. Medical Device technologies embrace a wide range of scientific, engineering and medical knowledge, with the goal of assisting a clinical professional (doctor or nurse) deliver a service to a patient in an efficacious, cost effective manner. Development of appropriate medical devices, whether for diagnosis, treatment or prevention of disease or disability, is critical to improving h ....The Australian Research Network for Medical Devices: advanced technology solutions for patients and practitioners. Medical Device technologies embrace a wide range of scientific, engineering and medical knowledge, with the goal of assisting a clinical professional (doctor or nurse) deliver a service to a patient in an efficacious, cost effective manner. Development of appropriate medical devices, whether for diagnosis, treatment or prevention of disease or disability, is critical to improving health care and reducing health care costs. To be successful, a device must include all relevant disciplines in the research, development and testing phases. This network will bring together these groups, promoting knowledge sharing and cross-disciplinary investigations that illuminate current device limitations and potential solutions.Read moreRead less
Parent involvement goes online: New ecologies of school-home relations. This project aims to: identify forms of digital exclusion and inclusion impacting on parents’ ability to support their children’s education; produce a new conceptual model of technologically mediated school-home relationships; and provide a comprehensive map of school-home connected digital tools and services. Combining a detailed survey of 500 school leaders with innovative networked case studies across three schools and 18 ....Parent involvement goes online: New ecologies of school-home relations. This project aims to: identify forms of digital exclusion and inclusion impacting on parents’ ability to support their children’s education; produce a new conceptual model of technologically mediated school-home relationships; and provide a comprehensive map of school-home connected digital tools and services. Combining a detailed survey of 500 school leaders with innovative networked case studies across three schools and 18 families, this will be the first national study to comprehensively describe and analyse home-school partnerships in the digital age. It will provide policy and educational leadership with a roadmap for addressing barriers to digital inclusion, as schools advance their integration of digital platforms. Read moreRead less