Innovative approaches to understanding and limiting the public health risks of Cryptosporidium and Giardia in animals in Australian catchments. Sophisticated molecular typing and modelling will be used to determine if chlorine-resistant parasites in animals in catchments are responsible for infection in humans. Improved catchment management and risk mitigation strategies will be developed during this project, which will make a substantial contribution to the provision of safe drinking water acro ....Innovative approaches to understanding and limiting the public health risks of Cryptosporidium and Giardia in animals in Australian catchments. Sophisticated molecular typing and modelling will be used to determine if chlorine-resistant parasites in animals in catchments are responsible for infection in humans. Improved catchment management and risk mitigation strategies will be developed during this project, which will make a substantial contribution to the provision of safe drinking water across Australia.Read moreRead less
From economic benefit to social cost: Antecedents of irresponsible gambling. The social impact of gambling is a challenge for policy-makers. Australia's gambling expenditure in 2001 contributed $4.4 billion in tax revenue. This economic benefit however, is offset by significant social costs ($1.8 to $5.6 billion). We will identify when and how distorted memory for previous gambling outcomes and gaming machine accessibility can cause irresponsible gambling. The results can be used to make informe ....From economic benefit to social cost: Antecedents of irresponsible gambling. The social impact of gambling is a challenge for policy-makers. Australia's gambling expenditure in 2001 contributed $4.4 billion in tax revenue. This economic benefit however, is offset by significant social costs ($1.8 to $5.6 billion). We will identify when and how distorted memory for previous gambling outcomes and gaming machine accessibility can cause irresponsible gambling. The results can be used to make informed assessments of the social impact of increasing the accessibility of gambling opportunities on local communities. The results can also be used to understand how gambling that contributes to the economy of a community becomes a social cost.Read moreRead less
Executive functioning, gender, age and medication as predictors of developmental well-being among students with ADHD. This study constructs social-cognitive phenotypes of ADHD, evaluates mental health and investigates ADHD student perceptions of classroom environment and achievement in science as functions of executive functioning, gender, age and medication. The effect of standard psychostimulant intervention and a novel nonpsychostimulant option on executive function, developmental and educati ....Executive functioning, gender, age and medication as predictors of developmental well-being among students with ADHD. This study constructs social-cognitive phenotypes of ADHD, evaluates mental health and investigates ADHD student perceptions of classroom environment and achievement in science as functions of executive functioning, gender, age and medication. The effect of standard psychostimulant intervention and a novel nonpsychostimulant option on executive function, developmental and educational outcomes will be investigated. The expected outcomes will inform more effective teacher professional development, and reduce school problems associated with psychostimulant medication and its illicit distribution by students. The linkage of health and education partners meets a nationally identified need for more effective collaboration to improve education outcomes for ADHD students.Read moreRead less
Mechanism of action of an anti-inflammatory compound which targets alternatively activated macrophages. The project will study the mechanism by which a novel anti-inflammatory compound, developed by our commercial partner, suppresses the activity of a population of cells known as alternatively activated macrophages. These cells play a key role in driving allergic inflammation, including the inflammation associated with asthma.
Troublesome ticks: a new molecular toolkit to investigate zoonotic tick-borne pathogens in Australia. This project will use the latest molecular diagnostic techniques to address unanswered questions about potential tick-transmitted diseases of humans and companion animals in Australia. The study will identify 'hot-spots' for tick-borne pathogens, identify areas of potential risk for humans, and investigate vector-host-pathogen interactions nationwide.
Ecology and transmission of tick-borne disease in Australia. Ecology and transmission of tick-borne disease in Australia. This project aims to determine the bacterial, protozoal and viral biodiversity in wildlife ticks and their native mammal hosts, and provide new information about the biology and transmission dynamics of these microorganisms and their potential to cause disease in wildlife, domesticated animals and humans. Anticipated outcomes are improved diagnostic tests and management proto ....Ecology and transmission of tick-borne disease in Australia. Ecology and transmission of tick-borne disease in Australia. This project aims to determine the bacterial, protozoal and viral biodiversity in wildlife ticks and their native mammal hosts, and provide new information about the biology and transmission dynamics of these microorganisms and their potential to cause disease in wildlife, domesticated animals and humans. Anticipated outcomes are improved diagnostic tests and management protocols for tick-borne disease in Australia.Read moreRead less
Identification of novel markers of inflammation. This project will benefit Australia as it will increase basic understanding of inflammatory processes, result in a new generation of diagnostics for inflammatory diseases that could lead to earlier diagnosis and to monitor treatment, resulting in large economic and health benefit. It may lead to development of novel new therapies using monoclonal antibodies to regulate processes in immune, cardiovascular and infectious diseases. The work will gene ....Identification of novel markers of inflammation. This project will benefit Australia as it will increase basic understanding of inflammatory processes, result in a new generation of diagnostics for inflammatory diseases that could lead to earlier diagnosis and to monitor treatment, resulting in large economic and health benefit. It may lead to development of novel new therapies using monoclonal antibodies to regulate processes in immune, cardiovascular and infectious diseases. The work will generate significant economic spin-offs to the Australian biotechnology industry and will further relationships and training between research and development.Read moreRead less
NOVEL THERAPEUTICS FOR AUTOIMMUNE DISEASE USING MOUSE SCREENING MODELS. The project aims to use experimental models of human autoimmune disease in the mouse for the testing of developmental isoflavonoid compounds produced by the Industry Partner, for protective effects against autoimmunity. The murine models proposed will duplicate human autoimmune cardiomyopathy, systemic lupus erythematosus and multiple sclerosis, encompassing both organ-specific and systemic autoimmune diseases. Isoflavonoi ....NOVEL THERAPEUTICS FOR AUTOIMMUNE DISEASE USING MOUSE SCREENING MODELS. The project aims to use experimental models of human autoimmune disease in the mouse for the testing of developmental isoflavonoid compounds produced by the Industry Partner, for protective effects against autoimmunity. The murine models proposed will duplicate human autoimmune cardiomyopathy, systemic lupus erythematosus and multiple sclerosis, encompassing both organ-specific and systemic autoimmune diseases. Isoflavonoid protection is anticipated from the antioxidant, anti-inflammatory and oestrogenic characteristics of these compounds/Read moreRead less
Chemo-prevention of tropical canine parasitoses and vector-borne diseases. This project will determine the prevalence and diversity of established, emerging and novel canine vector-borne agents and endoparasites in a tropical setting by using conventional and next generation molecular diagnostic tools. It will fill an important gap by providing independently-verified evidence on how well canine anti-parasitic products marketed in Australia and Asia by Bayer Animal Health, perform in high-infecti ....Chemo-prevention of tropical canine parasitoses and vector-borne diseases. This project will determine the prevalence and diversity of established, emerging and novel canine vector-borne agents and endoparasites in a tropical setting by using conventional and next generation molecular diagnostic tools. It will fill an important gap by providing independently-verified evidence on how well canine anti-parasitic products marketed in Australia and Asia by Bayer Animal Health, perform in high-infection pressure settings, as a chemo-preventative for these disease agents. Tropical regions spanning northern Australia and Southern Asia are highly conducive to a plethora of canine vector-borne and parasitic pathogens that cause significant morbidity and mortality in dogs. Many of these agents also pose a risk to public health. The outcomes will be directly translated to best-practice guidelines for the advancement of companion animal (and indirectly human) health and welfare.Read moreRead less
Training for Adaptability: The role of errors, exceptions and rules of thumb. This project involving collaboration among three fire services across two states and two universities aims to develop theoretical and evidenced-based error and exceptions training in the prediction of fire behaviour among novices and experts. The project will advance significantly our understanding of ways of adapting knowledge and updating and improving rules of thumb for complex decision-making. An innovative new cri ....Training for Adaptability: The role of errors, exceptions and rules of thumb. This project involving collaboration among three fire services across two states and two universities aims to develop theoretical and evidenced-based error and exceptions training in the prediction of fire behaviour among novices and experts. The project will advance significantly our understanding of ways of adapting knowledge and updating and improving rules of thumb for complex decision-making. An innovative new critical incident recording system will be developed that identifies the cognitive determinants of errors. Tightly controlled laboratory studies will be combined with field studies leading to improved theoretical understanding as well as practical outcomes for the fire services.Read moreRead less