From shape to function: how structured RNA defines insect flaviviruses. The goal of this project is to obtain an understanding of how insect-specific flaviviruses (ISFs) utilise viral noncoding RNAs to enable their replication in mosquitoes. These viruses only replicate in mosquitoes, and not in humans or animals. They can be employed as the biocontrol agents for mosquito-borne diseases as they make mosquitoes incapable of disease transmission. However, it is currently unknown how exactly insect ....From shape to function: how structured RNA defines insect flaviviruses. The goal of this project is to obtain an understanding of how insect-specific flaviviruses (ISFs) utilise viral noncoding RNAs to enable their replication in mosquitoes. These viruses only replicate in mosquitoes, and not in humans or animals. They can be employed as the biocontrol agents for mosquito-borne diseases as they make mosquitoes incapable of disease transmission. However, it is currently unknown how exactly insect-specific flaviviruses affect mosquitoes and this information is vital for informed design of ISF-based interventions. The project will generate new knowledge on functions of noncoding RNAs in ISFs that are hypothesised to have immunomodulatory role in mosquitoes. It will also train students and ECRs.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100433
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Cortical layer specific functional imaging of the human brain. This project aims to record layer specific cortical activity in humans by leveraging ultra-high field magnetic resonance imaging. It expects to yield robust techniques for the general analysis of neuroimaging-based, layer-specific measurements. This project will progress the fields of cognitive neuroscience and neuroimaging as well as bring the field of neuroimaging closer to that of neurophysiology and thus facilitate collaboration ....Cortical layer specific functional imaging of the human brain. This project aims to record layer specific cortical activity in humans by leveraging ultra-high field magnetic resonance imaging. It expects to yield robust techniques for the general analysis of neuroimaging-based, layer-specific measurements. This project will progress the fields of cognitive neuroscience and neuroimaging as well as bring the field of neuroimaging closer to that of neurophysiology and thus facilitate collaboration among researchers.Read moreRead less
Determining principles for successful episode retrieval of repeated events. This project aims to develop the first-ever set of explanatory principles for how people successfully retain and retrieve individual episode memories from repeated experiences (e.g., one occurrence of a routine social encounter or job-related activity). By deepening our understanding of how memory works, this new knowledge is expected to lay the foundation for interview guidance and ongoing research aimed at enhancing th ....Determining principles for successful episode retrieval of repeated events. This project aims to develop the first-ever set of explanatory principles for how people successfully retain and retrieve individual episode memories from repeated experiences (e.g., one occurrence of a routine social encounter or job-related activity). By deepening our understanding of how memory works, this new knowledge is expected to lay the foundation for interview guidance and ongoing research aimed at enhancing the proficiency of investigations into matters that rely on detailed and accurate accounts of specific episodes. This includes workplace or traffic accident investigations, infectious disease contact tracing, as well as prosecution of repeated sexual offences.Read moreRead less
Reducing health disparities for culturally and linguistically diverse peoples. This project aims to develop a greater understanding of migrants and the factors that predict poor health outcomes related to blood-borne viruses and sexually transmitted infections. The delayed access by migrants to healthcare from culturally and linguistically diverse backgrounds results in late diagnosis, low treatment uptake, and poorer health outcomes, with enhanced risk of infection and increased burden on the h ....Reducing health disparities for culturally and linguistically diverse peoples. This project aims to develop a greater understanding of migrants and the factors that predict poor health outcomes related to blood-borne viruses and sexually transmitted infections. The delayed access by migrants to healthcare from culturally and linguistically diverse backgrounds results in late diagnosis, low treatment uptake, and poorer health outcomes, with enhanced risk of infection and increased burden on the health system. The data collected in this project will assist in developing health services to meet these needs.Read moreRead less
Social, economic and health vulnerabilities in Indonesia. This project aims to study and provide ways to overcome vulnerability in Indonesia. Half the Indonesian population is still clustered around the poverty line, contributing to their vulnerability. This project will identify vulnerable groups and why they are vulnerable. Using a common framework of the life course in eight Indonesian field sites, this project will investigate whether social networks and welfare programs reduce vulnerability ....Social, economic and health vulnerabilities in Indonesia. This project aims to study and provide ways to overcome vulnerability in Indonesia. Half the Indonesian population is still clustered around the poverty line, contributing to their vulnerability. This project will identify vulnerable groups and why they are vulnerable. Using a common framework of the life course in eight Indonesian field sites, this project will investigate whether social networks and welfare programs reduce vulnerability, and pinpoint strategies for reducing vulnerabilities in the future. The project expects to show how vulnerable citizens in Indonesia can be made more secure, helping to build a more stable and prosperous region.Read moreRead less
A new model of teamwork for Human-Autonomy Teams (HATs). Human-Autonomy Teams (HATs) could potentially enhance most aspects of our daily lives; however, there are key knowledge gaps around HAT functioning and how to achieve optimal HAT performance. This research will apply a novel integration of systems analysis and computational modelling methods to develop, test, and validate a new model of teamwork in HATs. The model will clarify the processes and behaviours that support optimal HAT functioni ....A new model of teamwork for Human-Autonomy Teams (HATs). Human-Autonomy Teams (HATs) could potentially enhance most aspects of our daily lives; however, there are key knowledge gaps around HAT functioning and how to achieve optimal HAT performance. This research will apply a novel integration of systems analysis and computational modelling methods to develop, test, and validate a new model of teamwork in HATs. The model will clarify the processes and behaviours that support optimal HAT functioning, delineate HAT performance measures, and help to identify strategies to optimise HAT performance. The outcomes will provide a basis for future HAT research and ensure that the potential benefits of HATs are realised in areas such as defence, transport, healthcare, manufacturing, and disaster response.Read moreRead less
Information support tools for the trauma patient pathway. Processes such as critical supply chain management, disaster management, and trauma patient pathways need people, resources, and information to be smoothly transferred between jurisdictions, but problems can occur at each handover. This project focuses on the prehospital to hospital patient pathway and aims to develop technologies, devices, and displays to support more effective handover of patients between jurisdictions. The project will ....Information support tools for the trauma patient pathway. Processes such as critical supply chain management, disaster management, and trauma patient pathways need people, resources, and information to be smoothly transferred between jurisdictions, but problems can occur at each handover. This project focuses on the prehospital to hospital patient pathway and aims to develop technologies, devices, and displays to support more effective handover of patients between jurisdictions. The project will conduct field research, design activities, and simulation-based evaluation of prototypes with healthcare professionals. Expected outcomes are designs, technologies, and guidelines that will generalise to other multi-jurisdictional processes. Benefits are safer and more efficient handover processes.Read moreRead less
A global platform for identifying emerging chemical threats. This project aims to develop an automated early warning social network to systematically detect newly identified emerging chemical threats. Rapid identification of chemical exposures is key to managing chemical threats and associated risks. Global collaboration and sharing of archived, high-resolution mass spectrometry data through open/social platforms will revolutionise data processing and chemical threat identification. This project ....A global platform for identifying emerging chemical threats. This project aims to develop an automated early warning social network to systematically detect newly identified emerging chemical threats. Rapid identification of chemical exposures is key to managing chemical threats and associated risks. Global collaboration and sharing of archived, high-resolution mass spectrometry data through open/social platforms will revolutionise data processing and chemical threat identification. This project will result in a new and cost-effective approach for the identification, tracking and prioritisation of emerging chemical threats and address key national and global health risks. The outcomes include the first spatial and temporal distribution of new emerging chemical threats in Australia.Read moreRead less
Why certain viruses don't get along in mosquitoes. The molecular mechanism. The overall goal of this project is to obtain an understanding of how certain insect-only viruses make mosquitoes incapable of transmitting diseases. These viruses, called insect-specific flaviviruses, can be employed as biocontrol agents for mosquito-borne human and veterinary diseases. However as it is currently unknown how exactly they affect mosquitoes, the safety and efficacy of their use can't be predicted. The pro ....Why certain viruses don't get along in mosquitoes. The molecular mechanism. The overall goal of this project is to obtain an understanding of how certain insect-only viruses make mosquitoes incapable of transmitting diseases. These viruses, called insect-specific flaviviruses, can be employed as biocontrol agents for mosquito-borne human and veterinary diseases. However as it is currently unknown how exactly they affect mosquitoes, the safety and efficacy of their use can't be predicted. The proposed project will dissect the very intricate mechanisms of interactions between insect-specific flaviviruses and mosquitoes and explain how exactly they prevent disease transmission. It should generate novel fundamental knowledge, implement innovative methodologies and provide training for students and junior scientist. Read moreRead less
Can the Relational Account predict search in multiple-element displays? . This project provides evidence of a novel mechanism that guides visual attention. Our results confirm the existence of a mechanism that can rapidly and automatically assess the dominant feature(s) in a visual scene and radically change how attention is tuned to a target object. Moreover, this attention-guiding target template can change systematically as observers search through different items in visual search, possibly d ....Can the Relational Account predict search in multiple-element displays? . This project provides evidence of a novel mechanism that guides visual attention. Our results confirm the existence of a mechanism that can rapidly and automatically assess the dominant feature(s) in a visual scene and radically change how attention is tuned to a target object. Moreover, this attention-guiding target template can change systematically as observers search through different items in visual search, possibly due to a re-shaping and narrowing of the target template. These are both ground-breaking discoveries that have not been described before. Work on this project promises to lead to important theoretical breakthroughs, resolve current discrepancies in the literature and advance methods of Cognitive Psychology and Neuroscience.Read moreRead less