Proteomics of the Influenza Virus for In-field Surveillance. The influenza virus continues to pose a serious health risk to Australians and remains a leading cause of death. The molecular characterisation of emerging strains of the virus lies at the heart of current surveillance procedures vital to vaccine preparation and the development of new anti-viral drugs. This research will advance a world-first proteomics surveillance of the virus developed in this laboratory that will enable it to be ch ....Proteomics of the Influenza Virus for In-field Surveillance. The influenza virus continues to pose a serious health risk to Australians and remains a leading cause of death. The molecular characterisation of emerging strains of the virus lies at the heart of current surveillance procedures vital to vaccine preparation and the development of new anti-viral drugs. This research will advance a world-first proteomics surveillance of the virus developed in this laboratory that will enable it to be characterised in-field at the site(s) of infection outbreaks. This rapid response is vital, particularly in the event of a pandemic or a deliberate release of the virus in a bioterrorist attack.Read moreRead less
Aptamer imaging mass spectrometry for biomarker quantification. This project aims to develop novel methods for quantifying bio-markers in histological specimens using aptamers, lanthanide visualising tags and laser ablation plasma mass spectrometry. Aptamers are short synthetic strands of nucleic acid with complex three dimensional structures that bind targets with exquisite specificity. This technology meets a major gap in current imaging modalities, has wide application to basic biology and di ....Aptamer imaging mass spectrometry for biomarker quantification. This project aims to develop novel methods for quantifying bio-markers in histological specimens using aptamers, lanthanide visualising tags and laser ablation plasma mass spectrometry. Aptamers are short synthetic strands of nucleic acid with complex three dimensional structures that bind targets with exquisite specificity. This technology meets a major gap in current imaging modalities, has wide application to basic biology and diagnostics, and will eliminate the subjective interpretation of immunohistochemical stains.Read moreRead less
Endocrine Disrupting Compounds: Novel tests for Analysis and Field Validation. This project will give community benefits from new analytical technology and research data to help minimise the threat of environmental contamination with endocrine-disrupting compounds (EDCs). Both urban and rural communities may feel the impacts of EDCs, with potential contamination occurring globally, affecting both wildlife and humans. The main means of transport of EDCs is as contaminants in water and it is ess ....Endocrine Disrupting Compounds: Novel tests for Analysis and Field Validation. This project will give community benefits from new analytical technology and research data to help minimise the threat of environmental contamination with endocrine-disrupting compounds (EDCs). Both urban and rural communities may feel the impacts of EDCs, with potential contamination occurring globally, affecting both wildlife and humans. The main means of transport of EDCs is as contaminants in water and it is essential to learn the extent of contamination occurring in urban and rural water supplies to decide its significance. The research will involve a multi-disciplinary approach, with benefits falling into all four National Research Priorities of sustainability, good health, frontier analytical technology and national safety.Read moreRead less
Single cell glycomics: mapping the surface glycan signature of cells. This project aims to develop a platform technology for multiplexed glycan mapping of the surface of a single cell to address challenges of functional glycomics by utilising a conceptually new approach. By combining newly designed plasmonic nanoparticles with surface-enhanced Raman scattering tags and multiple specific carbohydrate-recognising lectins, this project expects to produce a generic technology that is capable of non- ....Single cell glycomics: mapping the surface glycan signature of cells. This project aims to develop a platform technology for multiplexed glycan mapping of the surface of a single cell to address challenges of functional glycomics by utilising a conceptually new approach. By combining newly designed plasmonic nanoparticles with surface-enhanced Raman scattering tags and multiple specific carbohydrate-recognising lectins, this project expects to produce a generic technology that is capable of non-destructive barcoding of the surface glycan signature of single cells in their native state and in response to metabolic perturbations. Expected project outcomes include advancing knowledge in nanobiotechnology, glycobiology and cell biology by being able to easily monitor changes to the surface of single cells.Read moreRead less
Bioinorganic chemistry between immune cell and pathogen. This project aims to investigate the bioinorganic chemistry that occurs when immune system cells encounter pathogens and they try to kill one another, or in the case of a pathogen, to also modify the genetics of the mammalian cell to enable its intracellular survival. Pathogenic bacteria and fungi accumulate chromium (Cr) in their membranes and it was recently discovered that Cr is likely to be an important virulence factor. Similarly, H ....Bioinorganic chemistry between immune cell and pathogen. This project aims to investigate the bioinorganic chemistry that occurs when immune system cells encounter pathogens and they try to kill one another, or in the case of a pathogen, to also modify the genetics of the mammalian cell to enable its intracellular survival. Pathogenic bacteria and fungi accumulate chromium (Cr) in their membranes and it was recently discovered that Cr is likely to be an important virulence factor. Similarly, Hyperaccummulation of Nickel (Ni) is also involved in virulence. The project will investigate the roles of Cr and Ni in virulence using advanced spectroscopic imaging and biochemical techniques. These insights will provide new knowledge on the innate immune system and may lead to more efficacious treatments for serious infections.Read moreRead less
Architectural Design Across Spaces and Cultures: Technology and Language. This project addresses two significant productivity barriers facing Australia’s architectural practices; designing in spatially distributed and culturally diverse teams.
While design practices are central to sustaining Australia’s creative export sector, growing concerns associated with online, multilingual design teams have been identified.
Directly responding to Australia’s COVID-19 recovery plans, this research seeks ....Architectural Design Across Spaces and Cultures: Technology and Language. This project addresses two significant productivity barriers facing Australia’s architectural practices; designing in spatially distributed and culturally diverse teams.
While design practices are central to sustaining Australia’s creative export sector, growing concerns associated with online, multilingual design teams have been identified.
Directly responding to Australia’s COVID-19 recovery plans, this research seeks to develop new knowledge about the cognitive, social and technical factors that shape the effectiveness of online international design teamwork. Its goal is to leverage the opportunities provided through technological advances and multicultural practices, to remove barriers to design productivity and enhance creativity.Read moreRead less
Development of new methods to measure in vivo properties of human body tissues. This project will develop new methods of noninvasively measuring the viscoelastic properties of soft tissues in live humans, using a novel magnetic resonance elastography technique. These methods will be applied to study the operation of the human muscle-tendon system, differences in neck muscle properties with age and gender and to measure the properties of the human brain, kidney and liver in vivo. These techniques ....Development of new methods to measure in vivo properties of human body tissues. This project will develop new methods of noninvasively measuring the viscoelastic properties of soft tissues in live humans, using a novel magnetic resonance elastography technique. These methods will be applied to study the operation of the human muscle-tendon system, differences in neck muscle properties with age and gender and to measure the properties of the human brain, kidney and liver in vivo. These techniques may be useful in diagnosing soft tissue disease or injury which are currently difficult to detect using standard imaging techniques. It will also explain how the muscle-tendon unit moves during normal motion in live humans.Read moreRead less
Latent variable modelling of discrete choice experiments. Discrete choice experiments and models are used to forecast consumer responses to changes in products policies and programs worldwide. Recent research suggests key model assumptions are violated because error variances covary with observed and unobserved factors. In order to address this, we will model systematic relationships between error variances and observed (eg, prices, survey length) and unobserved (eg, 'convenience', 'reputation') ....Latent variable modelling of discrete choice experiments. Discrete choice experiments and models are used to forecast consumer responses to changes in products policies and programs worldwide. Recent research suggests key model assumptions are violated because error variances covary with observed and unobserved factors. In order to address this, we will model systematic relationships between error variances and observed (eg, prices, survey length) and unobserved (eg, 'convenience', 'reputation') factors to improve model reliability and accuracy. This should lead to more accurate models/forecasts, benefitting business and government, which addresses the national priority of 'frontier technologies, promoting an innovative culture and economy'.Read moreRead less
Smart Information Use for PET-CT Quantitative Molecular Imaging. This project aims to use advanced computing algorithms to tackle
challenging problems associated with a new medical technology called
PET-CT which combines two imaging modalities in one device. While this technology is very new and has great potential in cancer and brain disorders, it also poses major challenges for information processing and transmission. We will address these challenges by developing advanced algorithms that op ....Smart Information Use for PET-CT Quantitative Molecular Imaging. This project aims to use advanced computing algorithms to tackle
challenging problems associated with a new medical technology called
PET-CT which combines two imaging modalities in one device. While this technology is very new and has great potential in cancer and brain disorders, it also poses major challenges for information processing and transmission. We will address these challenges by developing advanced algorithms that optimally extract information from PET and CT using mathematical models that correct for the various sources of inaccuracy. Our research will put Australian biomedical researchers and healthcare professionals at the forefront of advanced medical imaging technology.Read moreRead less
Bayesian Inference for Flexible Parametric Multivariate Econometric Modelling. The anticipated outcomes include the development of enhanced multivariate econometric models and innovative computationally intensive methods for their estimation. These models are used in numerous and diverse applications which are data-intensive and where more complete models will greatly enhance data-based decision-making. Results include improved information use in the wholesale electricity markets, in financial m ....Bayesian Inference for Flexible Parametric Multivariate Econometric Modelling. The anticipated outcomes include the development of enhanced multivariate econometric models and innovative computationally intensive methods for their estimation. These models are used in numerous and diverse applications which are data-intensive and where more complete models will greatly enhance data-based decision-making. Results include improved information use in the wholesale electricity markets, in financial market investment decision-making and for the assessment of the impact of internet advertising.Read moreRead less