microRNAs and the control of T lymphocyte differentiation, function and malignant transformation. The molecular mechanism of the immune system is not completely understood. This project will investigate how transcription factors and microRNAs, two major types of regulatory molecules work together to control immune responses. The results from this research will assist in the design of better vaccination strategies and treat certain lymphomas.
RNA-binding proteins rewire transcriptomes in immune cell differentiation. This project aims to combine advanced computational and experimental techniques to investigate a new layer of gene regulation by novel RNA binding proteins (RBP) which control messenger RNA length in immune cells. This project expects to demonstrate that these RBPs have a profound effect on immune cell differentiation and response to infection. Expected outcomes include the discovery of new RBPs regulating immunity, with ....RNA-binding proteins rewire transcriptomes in immune cell differentiation. This project aims to combine advanced computational and experimental techniques to investigate a new layer of gene regulation by novel RNA binding proteins (RBP) which control messenger RNA length in immune cells. This project expects to demonstrate that these RBPs have a profound effect on immune cell differentiation and response to infection. Expected outcomes include the discovery of new RBPs regulating immunity, with mechanism and function determined by novel CRISPR editing of a transgenic mouse model. The significant benefit will be a more complete understanding of RNA mechanisms of immune response, which will be critical in informing future advances in the rapidly developing areas of RNA-based biotechnologies and synthetic immunology.Read moreRead less
The epigenetic blueprint for T cell differentiation: a genomic view. A cardinal feature of adaptive immune cell activation is the initiation of a program of differentiation that results in acquisition and long term maintenance of lineage-speci?c effector function. This proposal aims to map and dissect genome wide molecular changes that occur at different stages of immune cell differentiation and identify key factors that regulating these changes. It is expected that distinct genomic signatures, ....The epigenetic blueprint for T cell differentiation: a genomic view. A cardinal feature of adaptive immune cell activation is the initiation of a program of differentiation that results in acquisition and long term maintenance of lineage-speci?c effector function. This proposal aims to map and dissect genome wide molecular changes that occur at different stages of immune cell differentiation and identify key factors that regulating these changes. It is expected that distinct genomic signatures, and the mechanisms indicative of effective immune cell differentiation will be identified. This proposal will provide insights into key mechanisms that result in reprogramming of immune cell function and memory and have implications for understanding general cellular differentiation.Read moreRead less
Indonesian Democracy: The Politics of Failed Reform and Regime Viability. Despite high hopes following the fall of Indonesia's authoritarian regime, political reform has been limited. The project examines the reasons for slow progress. Among the areas to be studied are constitutional and electoral reform, military reform, judicial reform, decentralisation, preservation of order and economic reform. It will argue that the weakness of the state in carrying out reforms is largely due to the penetra ....Indonesian Democracy: The Politics of Failed Reform and Regime Viability. Despite high hopes following the fall of Indonesia's authoritarian regime, political reform has been limited. The project examines the reasons for slow progress. Among the areas to be studied are constitutional and electoral reform, military reform, judicial reform, decentralisation, preservation of order and economic reform. It will argue that the weakness of the state in carrying out reforms is largely due to the penetration of the state itself by vested interests. Limited reforms have only been implemented when the viability of the regime itself has been at stake. This research is significant for Indonesian politics and political theory.Read moreRead less
Expectations and commitments in the Australia-USA alliance. This project aims to investigate the gap between the high expectations of mutual support and the lack of detailed security commitments in the Australia-US Alliance. The project intends to use a focused approach that captures thematic aspects of the alliance through project frames and historical slices across time. Expected outcomes can advance understanding of how alliances operate as security institutions. The outcomes can help to prom ....Expectations and commitments in the Australia-USA alliance. This project aims to investigate the gap between the high expectations of mutual support and the lack of detailed security commitments in the Australia-US Alliance. The project intends to use a focused approach that captures thematic aspects of the alliance through project frames and historical slices across time. Expected outcomes can advance understanding of how alliances operate as security institutions. The outcomes can help to promote a more informed national conversation about the costs and benefits of Australia's security relationship with the United States of America (USA) and contribute to debates over the future of the Australia-USA Alliance during a period of strategic uncertainty.Read moreRead less
Impact of evaluation-based funding on the content of scientific research. Evidence suggests that evaluation-based funding mechanisms trigger adaptive behaviour in scientists, leading to unintended changes in knowledge production. However, there is no conclusive evidence about when (under what circumstances), how (by what processes) and with what effects researchers adapt to these mechanisms. This study aims to answer these crucial questions. To overcome the methodological weaknesses of earlier s ....Impact of evaluation-based funding on the content of scientific research. Evidence suggests that evaluation-based funding mechanisms trigger adaptive behaviour in scientists, leading to unintended changes in knowledge production. However, there is no conclusive evidence about when (under what circumstances), how (by what processes) and with what effects researchers adapt to these mechanisms. This study aims to answer these crucial questions. To overcome the methodological weaknesses of earlier studies, a comparative investigation of several research fields and universities will be conducted, combining for the first time: qualitative interviews, ethnographic observations and bibliometric studies. It will enhance Australian research policy with a critical assessment of existing research funding models.Read moreRead less
Towards Generalisable and Unbiased Dynamic Recommender Systems. This project aims to develop the foundations, including models, methodology, and algorithms for building generalisable and unbiased dynamic recommender systems to facilitate intelligent decision-making, prompt contextualised and personalised strategic plans, and support context-aware action recourse. To ensure that fundamental principles, such as fairness and transparency, are respected, a set of algorithms and techniques are propos ....Towards Generalisable and Unbiased Dynamic Recommender Systems. This project aims to develop the foundations, including models, methodology, and algorithms for building generalisable and unbiased dynamic recommender systems to facilitate intelligent decision-making, prompt contextualised and personalised strategic plans, and support context-aware action recourse. To ensure that fundamental principles, such as fairness and transparency, are respected, a set of algorithms and techniques are proposed to develop recommender systems in a more responsible manner. The result of this project will not only maintain Australia's leadership in this frontier research area, but also serve as an excellent vehicle for the education and training of Australia's next generation of scholars and engineers.Read moreRead less
Radical right populist parties. This project aims to explain why some radical right-wing populists in Western democracies enter governmental alliances with mainstream parties while others remain isolated. The emergence, spread and electoral success of radical right populists is a problem facing liberal democracy in the twenty-first century. While these parties’ policies, ideologies and rhetoric are similar, their relationships with mainstream parties are different. By examining explanatory facto ....Radical right populist parties. This project aims to explain why some radical right-wing populists in Western democracies enter governmental alliances with mainstream parties while others remain isolated. The emergence, spread and electoral success of radical right populists is a problem facing liberal democracy in the twenty-first century. While these parties’ policies, ideologies and rhetoric are similar, their relationships with mainstream parties are different. By examining explanatory factors that Political Science studies have so far been neglected, this project seeks to explain this variation and explore its implications for coalition theory.Read moreRead less
Australian Parliamentary Speech: How Deliberative? How Representative? . This project aims to assess the Australian Parliament’s representativeness and quality of debate from 1901-2020. It expects to generate new tools and knowledge about the development and workings of parliament using innovative quantitative text analysis methods. Expected outcomes include analysis of the relationship between representation (class, gender etc) and policy outcomes, an information-based measure of parliamentary ....Australian Parliamentary Speech: How Deliberative? How Representative? . This project aims to assess the Australian Parliament’s representativeness and quality of debate from 1901-2020. It expects to generate new tools and knowledge about the development and workings of parliament using innovative quantitative text analysis methods. Expected outcomes include analysis of the relationship between representation (class, gender etc) and policy outcomes, an information-based measure of parliamentary speech and a standardised dataset of Hansard. This should provide significant benefits to the scholarly community by removing cost and time barriers and build capacity for international collaborations. The objective information generated can contribute to public discussion about the efficacy of parliamentary debate.Read moreRead less
An Empirical Study of Agenda Setting in the High Court of Australia. This project aims to undertake the first comprehensive study of institutional and individual factors that facilitate and constrain access to judicial power via the High Court’s agenda setting process, special leave. Using quantitative methods, the project expects to generate new and advanced knowledge about the High Court’s role as the gatekeeper of judicial power. Expected outcomes include foundational knowledge on the nature ....An Empirical Study of Agenda Setting in the High Court of Australia. This project aims to undertake the first comprehensive study of institutional and individual factors that facilitate and constrain access to judicial power via the High Court’s agenda setting process, special leave. Using quantitative methods, the project expects to generate new and advanced knowledge about the High Court’s role as the gatekeeper of judicial power. Expected outcomes include foundational knowledge on the nature and scope of access to judicial power in Australia via policy reports, scholarly articles and datasets. This should provide significant benefits such as important insights on the impact and influence of justices, litigants, lawyers, and governments on High Court’s decisions to grant or deny special leave to appeal.Read moreRead less