Towards Improved Respiratory Outcomes In Preterm Infants Through Rapid And Effective Aerosalisation Of Medication To The Lung
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Babies born premature are greatest at risk from increasingly common respiratory illnesses. It is possible that delivering a medication by aerosol will be the most effective method of treatment. For premature babies that need breathing support, inhaled medication could improve care. For highly infectious respiratory illnesses such as RSV, with no vaccines available, we need to protect babies very early in life. I will use an established lamb model to test fast medication delivery to the lungs.
Comparing Pneumococcal Vaccines In A High Risk Population: A Randomised Controlled Trial Of Immunogenicity, Safety And Impact On Carriage Of Pneumococcal Conjugate And Polysaccharide Vaccines In Infants In Papua New Guinea
Funder
National Health and Medical Research Council
Funding Amount
$1,042,670.00
Summary
Pneumococcal disease is a major cause of pneumonia and meningitis in infants in developing countries in particular resulting in an estimated 800,000 deaths each year. This project will study how well pneumococcal vaccines perform in 260 high-risk infants in Papua New Guinea. We will examine how well the vaccines stimulate protective immunity and reduce babies carrying the pneumococcal bacteria in their nose and how long this immunity lasts for. The study will inform global immunisation policy.
Strategies To Reduce The Burden Of Gastroenteritis In Aboriginal Children.
Funder
National Health and Medical Research Council
Funding Amount
$124,676.00
Summary
Rotavirus is the leading cause of severe gastroenteritis in children. Despite early promise, vaccines which target rotavirus seem to be less effective in low-resource settings and also amongst Australian Indigenous children. This study seeks to assess whether an extra dose of rotavirus vaccine (RV1) will improve the effectiveness of rotavirus vaccine in Aboriginal children and result in decreased admissions and clinic visits in the first three years of life.
Randomised Controlled Trial Of The Use Of Nitazoxanide Versus Placebo To Treat Gastroenteritis Among Aboriginal Children
Funder
National Health and Medical Research Council
Funding Amount
$1,324,808.00
Summary
Better treatment strategies are needed for Indigenous children with gastroenteritis. At present, most treatment is supportive only, with little effect on the duration of symptoms. Nitazoxanide appears to have effects on a broad range of pathogens which cause gastroenteritis, but it is not clear whether it will be of benefit in this population. We will compare the speed of symptom resolution in children who receive nitazoxanide with a group who receive a placebo instead.
Otitis Media, Hearing Loss And School Readiness Of Indigenous Children Followed From Birth In Two Randomised Controlled Trials Of Novel Pneumococcal Conjugate Vaccine Schedules (VOICES. Vaccines To Prevent Otitis Media In Children Entering School)
Funder
National Health and Medical Research Council
Funding Amount
$1,317,169.00
Summary
Educational and health outcomes of Indigenous children are extremely poor, particularly in remote areas. High rates of ear disease, particularly “runny ears” and “glue ear”, and hearing loss throughout early childhood contribute to developmental delay. Vaccines to prevent ear disease could be used more effectively. This project is evaluating a novel combination schedule of two different licenced vaccine formulations to maximise protection and improve ear health, hearing and school readiness.
A Multi-centre, Double-blind, Randomised Controlled Trial To Evaluate The Efficacy Of 10 Valent-pneumococcal-Protein D Conjugate Vaccine In Reducing Respiratory Exacerbations In Children Aged ? 18 Months With Suppurative Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$1,160,660.00
Summary
Chronic suppurative (ie infected) lung diseases in children are major causes of poor health and deaths worldwide. Repeated childhood infections contribute to poor lung health in adults. The most common organism causing infection is non-typeable Haemophilus influenzae (NTHi). This study aims to determine whether a vaccine against NTHi can reduce repeated respiratory infections in children. If so, vaccination may lead to substantial improvements in current/ future lung health, and considerable dir ....Chronic suppurative (ie infected) lung diseases in children are major causes of poor health and deaths worldwide. Repeated childhood infections contribute to poor lung health in adults. The most common organism causing infection is non-typeable Haemophilus influenzae (NTHi). This study aims to determine whether a vaccine against NTHi can reduce repeated respiratory infections in children. If so, vaccination may lead to substantial improvements in current/ future lung health, and considerable direct and indirect cost of disease savings.Read moreRead less
A Centre For Research Excellence In Cerebral Palsy (CRE-CP)
Funder
National Health and Medical Research Council
Funding Amount
$2,622,042.00
Summary
Cerebral palsy is the most common physical disability in childhood. Our objective is to bring about a radical improvement in the treatment of individuals with cerebral palsy, both children and adults, and to determine better ways to assist their families. Emphasis will be placed on early detection of health issues and rigorous evaluation of management options. We will train more researchers and ensure that all the knowledge generated is made available to families and health care professionals.