Media Formulations To Enhance Embryo Formation In Assisted Reproduction
Funder
National Health and Medical Research Council
Funding Amount
$660,133.00
Summary
The increasing age of parenthood has led to an explosion in the demand for assisted reproductive technologies such as in vitro fertilisation (IVF). This procedure has a poor success rate and is limited by the ability of fertilised eggs to mature into early embryos in the lab prior to being transferred into women. We will develop new compounds that improve embryo growth in the clinic, which will improve IVF success rates.
Nicotinamide Adenine Dinucleotide (NAD+)-raising Agents For Improving Oocyte Quality
Funder
National Health and Medical Research Council
Funding Amount
$445,827.00
Summary
Many women cannot have children because of suboptimal egg quality, often due to aging. Currently, the only option is to use better quality eggs donated from another woman. This project will use pharmacological agents to promote recently discovered pathways in eggs central to determining quality. Importantly, we will investigate a simple and practical approach that can be used in clinics for augmenting these pathways to improve oocyte quality for the first time.
Integrating choice set formation and taste heterogeneity in market segmentation. This project develops a new model of consumer decision-making to provide managerial insights related to market segmentation, product portfolio optimisation and marketing communication strategies. The model can be specified for a particular product category using data collected from a novel elicitation instrument developed as part of this project.
Molecular force sensing mechanisms of PIEZO channels. The aim of this project is to characterise the gating mechanism of Piezo mechanosensitive ion channels recently identified in animals and humans. Mechanotransduction is ancient, as indicated by the presence of mechanosensitive channels in bacteria where these channels are activated by the bilayer mechanism according to the force-from-lipids paradigm possibly applicable to gating of the Piezo channels as well. Piezo channels play a crucial rol ....Molecular force sensing mechanisms of PIEZO channels. The aim of this project is to characterise the gating mechanism of Piezo mechanosensitive ion channels recently identified in animals and humans. Mechanotransduction is ancient, as indicated by the presence of mechanosensitive channels in bacteria where these channels are activated by the bilayer mechanism according to the force-from-lipids paradigm possibly applicable to gating of the Piezo channels as well. Piezo channels play a crucial role in senses of touch and pain, and mutations in Piezo1 have been shown to cause Xerocytosis – a hereditary genetic disorder manifested in haemolytic anemia. This project aims to help answer fundamental questions in mechanotransduction in vertebrates.Read moreRead less
Exploration, Generalisation and the Development of Learning Traps. This project addresses three fundamental questions about human decision-making; 1) how does exploratory choice lead to “learning traps”, persistent patterns of poor decision-making that cause us to miss rewards and experience losses? 2) how does susceptibility to traps change with age? 3) what strategies prevent traps or facilitate escape? The project will advance our understanding of the cognitive processes underlying adult and ....Exploration, Generalisation and the Development of Learning Traps. This project addresses three fundamental questions about human decision-making; 1) how does exploratory choice lead to “learning traps”, persistent patterns of poor decision-making that cause us to miss rewards and experience losses? 2) how does susceptibility to traps change with age? 3) what strategies prevent traps or facilitate escape? The project will advance our understanding of the cognitive processes underlying adult and child decision-making, using innovative experimental paradigms and computational modeling. Expected outcomes include a novel computational model that explains developmental change in trap formation. The results will guide strategies for improved decision-making in educational, financial, and social settings.Read moreRead less
The value of time during decisions. This project aims to investigate how people value time during decision making. Using an innovative combination of carefully designed experiments and state-of-the-art mathematical cognitive models, this project expects to generate new knowledge regarding how efficiently people allocate time when making decisions, the factors that allow people to perform optimally and those that lead to suboptimal performance. The anticipated outcome of the project is a new fram ....The value of time during decisions. This project aims to investigate how people value time during decision making. Using an innovative combination of carefully designed experiments and state-of-the-art mathematical cognitive models, this project expects to generate new knowledge regarding how efficiently people allocate time when making decisions, the factors that allow people to perform optimally and those that lead to suboptimal performance. The anticipated outcome of the project is a new framework for understanding the optimality of human decision making. This outcome has the potential benefit of providing insight into decision mechanisms across a range of contexts, particularly ageing and models of applied decision making.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100177
Funder
Australian Research Council
Funding Amount
$365,000.00
Summary
Cognitive models of mental architectures in consumer preference. This project aims to characterise the mental architecture of consumer preference, the decision mechanisms and strategies that people use to select products or service options. It uses carefully designed experiments and cognitive modelling of mental architectures that capitalise on the information in the product decisions people make and the time taken to make them. The project provides insight into how people reason with and use in ....Cognitive models of mental architectures in consumer preference. This project aims to characterise the mental architecture of consumer preference, the decision mechanisms and strategies that people use to select products or service options. It uses carefully designed experiments and cognitive modelling of mental architectures that capitalise on the information in the product decisions people make and the time taken to make them. The project provides insight into how people reason with and use information to inform their decisions. This will help organisations to improve products and services and engage with consumers, to create competitive advantage, improve customer service and ultimately stimulate the economy.Read moreRead less
The role of households, neighbourhoods and networks in social statistics. Many issues affect the social progress of the country. Social research can determine the factors affecting issues such as unemployment, poverty, educational attainment, crime victimization and poor health. Survey and other data are used extensively to examine these conditions and their association with attributes of people. This project will provide methods to better determine the impact of effects associated with the h ....The role of households, neighbourhoods and networks in social statistics. Many issues affect the social progress of the country. Social research can determine the factors affecting issues such as unemployment, poverty, educational attainment, crime victimization and poor health. Survey and other data are used extensively to examine these conditions and their association with attributes of people. This project will provide methods to better determine the impact of effects associated with the household structure and other groups and social networks. The improved ability to assess the impact of these factors will have economic and social benefits. These benefits will arise from improved analysis leading to better decisions and improvements in the design of research studies improving their cost efficiency.Read moreRead less
Poor Women and Lonely Men: Examining Gendered Social Inclusion and Connection in Australia. This project directly supports the national research priority goal of 'strengthening Australia's social and economic fabric' (as part of Promoting and Maintaining Good Health). Inclusive societies reap many benefits (economic, education, crime, health etc), and information revealed about relevant gendered patterns will help build social inclusion and connection in Australia by informing inclusive strategi ....Poor Women and Lonely Men: Examining Gendered Social Inclusion and Connection in Australia. This project directly supports the national research priority goal of 'strengthening Australia's social and economic fabric' (as part of Promoting and Maintaining Good Health). Inclusive societies reap many benefits (economic, education, crime, health etc), and information revealed about relevant gendered patterns will help build social inclusion and connection in Australia by informing inclusive strategies and policies. The project also supports the national research priority goal 'ageing well and productively', by informing policy-contexts of specific disadvantage, such as amongst those ageing alone. The project will also add to broader understandings about the links between social inclusion, connection and wellbeing.Read moreRead less
Everyday autism: bridging the gap between lab and life. Recent research demonstrates that autistic people, their families and professionals often feel that there remains a sharp divide between autism science and key aspects of everyday autistic life, despite significant public investment in that science. This proposed research investigates reasons for this divide and proposes ways in which it might be overcome. Expected outcomes include greater opportunities for autistic people to play active ro ....Everyday autism: bridging the gap between lab and life. Recent research demonstrates that autistic people, their families and professionals often feel that there remains a sharp divide between autism science and key aspects of everyday autistic life, despite significant public investment in that science. This proposed research investigates reasons for this divide and proposes ways in which it might be overcome. Expected outcomes include greater opportunities for autistic people to play active roles in the research process and more scientific experimentation that moves out of the laboratory and into more true-to-life settings. Bridging the gap between lab and life will result in better theory-building on autism, better translation of scientific discoveries and more robust policy recommendations.Read moreRead less