Targeted Pelvic Floor Muscle Training For Urinary Incontinence After Radical Prostatectomy: A Randomised Controlled Trial With Embedded Physiological Studies
Funder
National Health and Medical Research Council
Funding Amount
$966,377.00
Summary
Prostatectomy is a common treatment for the most common cancer in men. Survival is good, but many develop debilitating urinary incontinence. Past pelvic floor muscle training has had limited effect, but recent work has changed understanding of how muscles control continence and compensate for surgery. This clinical trial compares innovative training individually tailored to optimise continence, usual exercise and no treatment, and aims to identify men most likely to benefit from treatment.
Role Of Sensory Neurons In Obstruction-induced Bladder Overactivity
Funder
National Health and Medical Research Council
Funding Amount
$340,986.00
Summary
About 20% of people over the age of 40 have the clinical syndrome of an “overactive bladder”, which causes symptoms of urgency, frequency and incontinence. The mechanisms causing bladder overactivity are not known. This project will identify sensory neurons, which become overexcited, and determine which mediators and ionic channels are responsible for this. Our new data will identify selective pharmacological targets for new therapies and diagnostic tools for these distressing bladder disorders.