Developing orthogonal synthetic signaling cascades. This project proposes a generic approach for the construction of molecular switches based on artificially autoinhibited proteases. The bottom-up design of protein-based signaling networks is a key goal of synthetic biology. Yet, this remains elusive due to our inability to tailor-make signal transducers and receptors that can be readily compiled into defined signaling networks. Using structure-guided design and directed protein evolution, a set ....Developing orthogonal synthetic signaling cascades. This project proposes a generic approach for the construction of molecular switches based on artificially autoinhibited proteases. The bottom-up design of protein-based signaling networks is a key goal of synthetic biology. Yet, this remains elusive due to our inability to tailor-make signal transducers and receptors that can be readily compiled into defined signaling networks. Using structure-guided design and directed protein evolution, a set of protease-based signal transducers and ligand activated allosteric receptors will be created. The developed components are intended to be used to construct artificial signaling networks in mammalian cells that are orthogonal to the endogenous signaling cascades.Read moreRead less
Rotating Radiofrequency Phased-array for 7 Tesla Magnetic Resonance Imaging. This project aims to develop a new type of radiofrequency coil array to ensure high-field magnetic resonance imaging (MRI), with all its benefits, is available for a broader range of applications. High-field MRI offers faster scans with more detailed images than lower field systems. This enhanced sensitivity potentially enables smaller structures to be resolved in the body. At high fields, however, standard radiofrequen ....Rotating Radiofrequency Phased-array for 7 Tesla Magnetic Resonance Imaging. This project aims to develop a new type of radiofrequency coil array to ensure high-field magnetic resonance imaging (MRI), with all its benefits, is available for a broader range of applications. High-field MRI offers faster scans with more detailed images than lower field systems. This enhanced sensitivity potentially enables smaller structures to be resolved in the body. At high fields, however, standard radiofrequency coils, an essential component of MRI systems, can distort images and induce potentially harmful tissue heating. The aim is to design and develop a rotating multi-channel radiofrequency coil array, with dedicated image reconstruction software, to overcome these limitations. This would facilitate detailed images that can be obtained quickly and safely.Read moreRead less
Engineering the Next Generation of Broadband Terahertz Technologies. This project proposes a new broadband, high-power, laser technology for THz sensing. This semiconductor laser based THz technology is crucial for a wide range of applications requiring the acquisition of THz spectral signatures of materials and high-frame rate hyper-spectral THz imaging. We propose two pathways to engineer this novel THz technology: using a tuneable, coupled-cavity quantum cascade semiconductor laser and by c ....Engineering the Next Generation of Broadband Terahertz Technologies. This project proposes a new broadband, high-power, laser technology for THz sensing. This semiconductor laser based THz technology is crucial for a wide range of applications requiring the acquisition of THz spectral signatures of materials and high-frame rate hyper-spectral THz imaging. We propose two pathways to engineer this novel THz technology: using a tuneable, coupled-cavity quantum cascade semiconductor laser and by creating the broad emission spectra through active mode locking in a THz semiconductor laser. The THz laser coupled with the self-detection technique is the key to realising this, and will be explored both in model and experiment.Read moreRead less
Silicon-germanium-carbon - a novel opto-mechanic material for optical micro-electromechanical systems. Evolving from past black-and-white images, through present red-green-blue multi-spectral capability, future remote imaging systems promise spectroscopic functionality across much broader wavelength ranges in a low-cost system. However, the high cost of multiple materials and technologies for each specific spectral band limits them to high-cost industry sectors. This project proposes a simple, l ....Silicon-germanium-carbon - a novel opto-mechanic material for optical micro-electromechanical systems. Evolving from past black-and-white images, through present red-green-blue multi-spectral capability, future remote imaging systems promise spectroscopic functionality across much broader wavelength ranges in a low-cost system. However, the high cost of multiple materials and technologies for each specific spectral band limits them to high-cost industry sectors. This project proposes a simple, low-cost, single material technology based on silicon-germanium-carbon thin films for mechanical and optical applications from ultraviolet to long-wave infrared, enabling widespread application of spectroscopic imaging to multiple fields extending from climate change research, through resource exploration, to cancer detection, and aerospace/defense.Read moreRead less
Re-Theorising Employee Voice in Times of Change. This project aims to generate new knowledge of the concept of employee voice as a part of organisational realignment throughout and following the CoVid-19 pandemic. The project aims to build a better theoretical modelling of efficient, effective “employee voice pathways” for the first time, including a understanding how voice changes over time. When confronted with a major external calamity, employee voice can play a critical role in any organisat ....Re-Theorising Employee Voice in Times of Change. This project aims to generate new knowledge of the concept of employee voice as a part of organisational realignment throughout and following the CoVid-19 pandemic. The project aims to build a better theoretical modelling of efficient, effective “employee voice pathways” for the first time, including a understanding how voice changes over time. When confronted with a major external calamity, employee voice can play a critical role in any organisation's success, as well as the employee wellbeing. Expected outcomes include rigorous empirical evidence and theoretical developments to inform new policy and support organisations' capacity to survive and thrive, as well a support employee wellbeing.Read moreRead less
Dielectric contrast imaging for 7 Tesla magnetic resonance applications. This project aims to develop novel radio-frequency (RF) technology, ensuring that the benefits of high-field magnetic resonance imaging (MRI) are available for a broader range of applications. This project will develop a new contrast mechanism directly related to the RF properties of individual tissue types, circumventing a limitation of intensity based imaging. This technology will enhance Australia’s global impact the dev ....Dielectric contrast imaging for 7 Tesla magnetic resonance applications. This project aims to develop novel radio-frequency (RF) technology, ensuring that the benefits of high-field magnetic resonance imaging (MRI) are available for a broader range of applications. This project will develop a new contrast mechanism directly related to the RF properties of individual tissue types, circumventing a limitation of intensity based imaging. This technology will enhance Australia’s global impact the development of imaging technology for healthcare, biomedical research and advanced diagnostics.Read moreRead less
How Can High-Performance Human Resource Management Improve Workforce Retention in Hospitals? Workforce shortages in hospitals are a major problem in Australia and internationally. Shortages may lead to a reduced provision of health services, lengthy waiting lists for treatment, excessive workloads for staff and increased likelihood of adverse outcomes. Despite a growth in labour supply, workforce shortages reflect, in part, an inability of hospitals to retain trained staff. Benefits to the com ....How Can High-Performance Human Resource Management Improve Workforce Retention in Hospitals? Workforce shortages in hospitals are a major problem in Australia and internationally. Shortages may lead to a reduced provision of health services, lengthy waiting lists for treatment, excessive workloads for staff and increased likelihood of adverse outcomes. Despite a growth in labour supply, workforce shortages reflect, in part, an inability of hospitals to retain trained staff. Benefits to the community of increasing workforce retention include: improved continuity and quality of care; increased throughput of patients; lower workforce recruitment costs; less staff burnout; and lower costs for training and educating new staff. Read moreRead less
The Role of Employment Relations in the Competitive Strategies of Low Cost Airlines in Australia. Employment-relations issues are key determinants of an airline's performance. Air transport is important for Australia. Australia has experienced failing airlines (e.g. Ansett, Compass); its most successful airline, Qantas, charges high fares and one of its priorities is improving its employment relations. This project will investigate airlines' critical success factors with special attention to the ....The Role of Employment Relations in the Competitive Strategies of Low Cost Airlines in Australia. Employment-relations issues are key determinants of an airline's performance. Air transport is important for Australia. Australia has experienced failing airlines (e.g. Ansett, Compass); its most successful airline, Qantas, charges high fares and one of its priorities is improving its employment relations. This project will investigate airlines' critical success factors with special attention to the links between corporate strategies and employment relations. Besides investigating Qantas, it will link with MIT's Global Airline Industry Program to consider the transformation of Australia's aviation industry and, in particular, the innovations pioneered by low-cost airlines: JetStar and Virgin Blue.Read moreRead less
Advanced Magnetic Resonance Imaging at 7 Tesla: Resolving the fundamental radiofrequency field-tissue interaction problem at ultra-high field. Ultra-high-field Magnetic Resonance Imaging (MRI) systems offer the potential for faster, more accurate diagnostic imaging. However, current applications are limited by the fundamental challenge of strong interactions between the electromagnetic field and human tissues, which result in poor image quality and/or compromised patient safety. Using a novel, s ....Advanced Magnetic Resonance Imaging at 7 Tesla: Resolving the fundamental radiofrequency field-tissue interaction problem at ultra-high field. Ultra-high-field Magnetic Resonance Imaging (MRI) systems offer the potential for faster, more accurate diagnostic imaging. However, current applications are limited by the fundamental challenge of strong interactions between the electromagnetic field and human tissues, which result in poor image quality and/or compromised patient safety. Using a novel, subject-specific imaging approach, this research will design and develop an ultra-high-field radiofrequency technology capable of offering high-performance imaging without jeopardising patient safety. This research will lay the groundwork for the translation of ultra-high field MRI research into clinical practice, generating new capabilities for diagnostic technologies.Read moreRead less
Towards direct imaging of neuronal currents with MRI. This project aims to develop novel neuronal current magnetic resonance imaging (nc-MRI) methods that harness the oscillatory behaviour of neuronal magnetic fields. Current methods of detecting neuronal activity in the living human brain have limited spatial and temporal resolution. Use of nc-MRI aims to overcome these limitations by imaging the effects on the MRI signal of small transient magnetic fields associated with neuronal activity. Sig ....Towards direct imaging of neuronal currents with MRI. This project aims to develop novel neuronal current magnetic resonance imaging (nc-MRI) methods that harness the oscillatory behaviour of neuronal magnetic fields. Current methods of detecting neuronal activity in the living human brain have limited spatial and temporal resolution. Use of nc-MRI aims to overcome these limitations by imaging the effects on the MRI signal of small transient magnetic fields associated with neuronal activity. Signal-to-noise ratio is at the limits of detectability using current imaging systems and nc-MRI is yet to be convincingly demonstrated. An integrated framework for simulating nc-MRI in the visual cortex is expected to be developed.Read moreRead less