Robotic microsurgery: intra-operative measurement, modelling and micromanipulation control. This research will significantly improve microsurgery and minimally invasive surgery techniques, and further produce important benefits to medicine and healthcare. The project will also open new domains in the capabilities of modelling and control of complex systems with significant impact and benefits to numerous science and engineering practices.
Imaging of properties of coherent elastic light scattering from turbid biological media. Imaging with coherent, elastically-scattered light for visualisation of thick-tissue morphology in vivo, or of cells buried deep in a turbid medium, remains a major challenge. We adopt an alternative approach of imaging of properties of light scattering based on regarding cellular tissue as a spatially-varying refractive-index continuum which encodes scattered light. We propose new methodologies to infer t ....Imaging of properties of coherent elastic light scattering from turbid biological media. Imaging with coherent, elastically-scattered light for visualisation of thick-tissue morphology in vivo, or of cells buried deep in a turbid medium, remains a major challenge. We adopt an alternative approach of imaging of properties of light scattering based on regarding cellular tissue as a spatially-varying refractive-index continuum which encodes scattered light. We propose new methodologies to infer tissue state and morphology indirectly based on phase delay, speckle, and angle-resolved scattering. We will break new ground in correlating the structure and function of in situ epithelial tissue and cells to light scattering enabling, e.g., the detection of mitosis and apoptosis in cells buried in thick, turbid media, and of cancers and precancers in vivo.Read moreRead less
Advances in optical coherence tomography. We propose to continue our research into the biomedical imaging technique of optical coherence tomography by making substantial new advances in the key areas of ultra-broad bandwidth operation, coincident confocal gate scanning, and dispersion compensation. These advances are aimed at improving resolution to the 1-5 micron range, which should allow a breakthrough to sub-cellular in vivo imaging, making visible sample histology in situ, which is currentl ....Advances in optical coherence tomography. We propose to continue our research into the biomedical imaging technique of optical coherence tomography by making substantial new advances in the key areas of ultra-broad bandwidth operation, coincident confocal gate scanning, and dispersion compensation. These advances are aimed at improving resolution to the 1-5 micron range, which should allow a breakthrough to sub-cellular in vivo imaging, making visible sample histology in situ, which is currently not possible. We also plan to make advances in the key area of scanning delay line technology by employing acousto-optics in OCT for the first time. Acousto-optics conveys advantages in no-moving-parts, scan-speed and accuracy.Read moreRead less
Silicon-germanium-carbon - a novel opto-mechanic material for optical micro-electromechanical systems. Evolving from past black-and-white images, through present red-green-blue multi-spectral capability, future remote imaging systems promise spectroscopic functionality across much broader wavelength ranges in a low-cost system. However, the high cost of multiple materials and technologies for each specific spectral band limits them to high-cost industry sectors. This project proposes a simple, l ....Silicon-germanium-carbon - a novel opto-mechanic material for optical micro-electromechanical systems. Evolving from past black-and-white images, through present red-green-blue multi-spectral capability, future remote imaging systems promise spectroscopic functionality across much broader wavelength ranges in a low-cost system. However, the high cost of multiple materials and technologies for each specific spectral band limits them to high-cost industry sectors. This project proposes a simple, low-cost, single material technology based on silicon-germanium-carbon thin films for mechanical and optical applications from ultraviolet to long-wave infrared, enabling widespread application of spectroscopic imaging to multiple fields extending from climate change research, through resource exploration, to cancer detection, and aerospace/defense.Read moreRead less
Dynamic Mechano-Microscopy for use in Mechanobiology . We will develop an innovative microscope that will enable new discoveries in biology. Most microscopes form images of a sample's optical properties, instead we will image a sample's mechanical properties. The reason our novel approach is needed is that cell behaviour depends on the stiffness of it's environment, but current microscopes are unable to image this. Our microscope will provide insights in biology that can improve our understandi ....Dynamic Mechano-Microscopy for use in Mechanobiology . We will develop an innovative microscope that will enable new discoveries in biology. Most microscopes form images of a sample's optical properties, instead we will image a sample's mechanical properties. The reason our novel approach is needed is that cell behaviour depends on the stiffness of it's environment, but current microscopes are unable to image this. Our microscope will provide insights in biology that can improve our understanding of cells, the building blocks of life. We will achieve this by: 1. Developing a microscope that combines microscopic resolution with rapid imaging; 2: Developing the capability to image both within the cell and its surrounding environment; and 3. Using our microscope to make discoveries in biology.Read moreRead less
Light Activated Electrochemistry: Microelectrode Arrays with just one wire. Electrochemistry requires each electrode to be connected to the external circuit by a wire. With many electrodes this means many wires. Wires limit electrode density in arrays and dictate that the electrode architecture must be predetermined. This project aims to remove the need for a wire for each electrode by using light to sequentially connect each electrode to a single wire. This will be achieved using modified silic ....Light Activated Electrochemistry: Microelectrode Arrays with just one wire. Electrochemistry requires each electrode to be connected to the external circuit by a wire. With many electrodes this means many wires. Wires limit electrode density in arrays and dictate that the electrode architecture must be predetermined. This project aims to remove the need for a wire for each electrode by using light to sequentially connect each electrode to a single wire. This will be achieved using modified silicon electrodes where irradiating with light causes an increase in conductivity at the illumination spot. The project will explore the variables that influence the spatial resolution and apply the ideas to making soft connects for nanoelectronics and making high density electrode arrays for electroanalysis.Read moreRead less
Experiments with Advanced Isolation Systems, Suspension and Test Masses Using ACIGA's High Optical Power Test Facility. This proposal will allow experimental verification of the performcane of of sapphire test masses and their associated isolation and suspension system in ACIGA's high optical power test facility at Gingin. The work will contribute to the worldwide effort to increase the sensitivity of laser interferometers to the level where known sources of gravitational waves can be detected ....Experiments with Advanced Isolation Systems, Suspension and Test Masses Using ACIGA's High Optical Power Test Facility. This proposal will allow experimental verification of the performcane of of sapphire test masses and their associated isolation and suspension system in ACIGA's high optical power test facility at Gingin. The work will contribute to the worldwide effort to increase the sensitivity of laser interferometers to the level where known sources of gravitational waves can be detected at a reasonable rate.Read moreRead less
Private Health Insurance and Utilisation of Health Care in Australia. The breakdown of activity between the Australian public and private health sectors is currently subject to considerable scrutiny. The combination of a comprehensive public system with minimal co-payments, but considerable waiting times for some treatment, and a private system with minimal waiting but sizeable co-payments has interesting economic implications for both consumer and provider behaviour. This research project will ....Private Health Insurance and Utilisation of Health Care in Australia. The breakdown of activity between the Australian public and private health sectors is currently subject to considerable scrutiny. The combination of a comprehensive public system with minimal co-payments, but considerable waiting times for some treatment, and a private system with minimal waiting but sizeable co-payments has interesting economic implications for both consumer and provider behaviour. This research project will explore the relationship between insurance status and utilisation of health care in Australia. Because insurance reduces the out-of-pocket price for consumers, they tend to purchase more care than they would without insurance.Read moreRead less
Enhancing biopharmaceuticals: A disruptive bioseparation resin technology. This project aims to develop an innovative and disruptive platform technology for designing and manufacturing tailor-made high-performance bioseparation resins to enhance biopharmaceuticals manufacturing. Bacterial cell factories will be developed to enable biotechnological production of innovative polyester bead-based bioseparation resins, which will revolutionise manufacturing of biopharmaceuticals. Expected outcomes o ....Enhancing biopharmaceuticals: A disruptive bioseparation resin technology. This project aims to develop an innovative and disruptive platform technology for designing and manufacturing tailor-made high-performance bioseparation resins to enhance biopharmaceuticals manufacturing. Bacterial cell factories will be developed to enable biotechnological production of innovative polyester bead-based bioseparation resins, which will revolutionise manufacturing of biopharmaceuticals. Expected outcomes of this project are cost-effective and strongly enhanced approaches for biopharmaceuticals recovery, thereby providing significant benefits to accelerate research and development in early stage discovery and manufacture of biologics, therapeutic proteins and vaccines.Read moreRead less
The production of pay (in)equity for women: a study of emerging occupations. The aims of this project are to extend understanding of current impediments to pay equity for women, and to elaborate the ways in which pay inequality is re-created in new contexts. The focus is on emerging occupations likely to provide increasing employment opportunities in the near future. This is highly significant research at a time of structural change and when new procedures for addressing pay equity are being dev ....The production of pay (in)equity for women: a study of emerging occupations. The aims of this project are to extend understanding of current impediments to pay equity for women, and to elaborate the ways in which pay inequality is re-created in new contexts. The focus is on emerging occupations likely to provide increasing employment opportunities in the near future. This is highly significant research at a time of structural change and when new procedures for addressing pay equity are being developed in several States following pay equity inquiries. Expected outcomes include enhanced comprehension of the reproduction of pay inequality and evidence to assist the advancement of pay equity through identified mechanisms and strategies.Read moreRead less