We are an international team committed to clinical trials to improve survival without disability in newborn babies. We plan a randomised trial to confirm if bovine lactoferrin, an inexpensive dairy protein, reduces death or major morbidity and increases total breast milk intake in 1,500 very low birthweight babies in neonatal intensive care units
A Randomised Controlled Trial Of Enhanced Parenting Capacity To Improve Developmental Outcomes In Preterm Infants
Funder
National Health and Medical Research Council
Funding Amount
$1,045,141.00
Summary
In Australia there are 2, 600 very preterm survivors each year. 50% will have education/behavioural difficulties and 10% major disability. We aim to optimise the development of infants born very preterm through a tailored Positive Parenting Program. We predict reductions in child behavioural and emotional problems at 2 years corrected age.
Docosahexaenoic Acid For The Reduction Of Bronchopulomonary Dysplasia In Preterm Infants Born At Less Than 29 Weeks Gestational Age: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,929,854.00
Summary
A major challenge in the care of very preterm babies, is dealing with the fact that the baby has very immature lungs. They are prone to an inflammatory condition known as BPD (broncho-pulmonary dysplasia) that prevents an infant from breathing, much like asthma in older children. This can result in poor health outcomes for life. Our study will test the effect of the omega 3 fat known as DHA in reducing this inflammation in the lung and result in better outcomes for the baby.
Tailoring A Brief Sleep Intervention For Autism: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$401,475.00
Summary
Up to 86% of children with Autism Spectrum Disorder (ASD) experience behavioural sleep problems which have been shown to be associated with increased core ASD symptoms, increased rates of internalizing and externalizing disorders, and increased parental stress. The “Sleeping Sound” study is a novel behavioural sleep intervention that has shown much promise as a treatment to reduce sleep problems and improve mental health outcomes in children with ASD.
Efficacy And Safety Of Omega-3 DHA Supplementation In Preterm Infants: Childhood Follow-up Of The N3RO Trial.
Funder
National Health and Medical Research Council
Funding Amount
$713,218.00
Summary
Giving babies born 3 to 4 months prematurely the omega-3 DHA has been thought to improve their mental development. But we don’t yet know if this is indeed so. In this follow-up study, we will be able to find out the important longer-term effects at 5-years of age of extra DHA in the first months of life by assessing the children’s mental development.
Primary Prevention Of Infant Food Allergy: A Randomised Controlled Trial Of Postnatal Vitamin D Supplementation
Funder
National Health and Medical Research Council
Funding Amount
$1,723,793.00
Summary
Low vitamin D has been linked to a range of health conditions but, unlike many countries, Australia does not recommend supplementing infants with vitamin D. Good quality research on the effectiveness of vitamin D supplementation to prevent disease is lacking. Our trial of 2330 infants examines whether a daily dose of vitamin D prevents the development of food allergy. Vitamin D is safe and low cost. Infant supplementation may be the first simple strategy to reduce this common childhood condition
The Impact Of Obesity On Immunological Tolerance Of The Fetus
Funder
National Health and Medical Research Council
Funding Amount
$378,366.00
Summary
Obesity increases the risk of miscarriage during pregnancy. The reasons for this are not known, although it is thought that abnormal levels of hormones and metabolic parameters are a contributing factor. We hypothesise that the immune system plays a role. In this project we will determine if obesity upsets the fine-tuning of the immune system that is crucial for successful pregnancy. Understanding the reason behind adverse pregnancy outcome will allow appropriate management of maternal obesity.
MAIT cells are a recently discovered type of lymphocyte that plays a unique and important role in the immune system. However, these cells vary widely in number between healthy individuals, for reasons that are unclear. This project is designed to understand the factors that control the development of MAIT cells as a step toward regulating their numbers and activity.
Understanding The Structure/function Relationships Of The Iron Regulatory Peptide Hepcidin
Funder
National Health and Medical Research Council
Funding Amount
$365,126.00
Summary
This project seeks to understand the interactions between the peptide hormone hepcidin and its receptor and use this information to develop new drugs. Hepcidin is the major iron-regulatory hormone in humans and a range of iron-related diseases are caused by incorrect levels of this hormone. Many Australians are affected by these diseases so the development of hepcidin-based treatments has the potential to have significant impact on the overall health of the community.
Regulatory T Cells And Cardiac Fibrosis In Hypertensive Heart Disease: Cellular And Molecular Mechanisms Of Suppression
Funder
National Health and Medical Research Council
Funding Amount
$715,316.00
Summary
Excessive accumulation of collagen in the heart, cardiac fibrosis is a major factor causing heart failure and sudden death. How collagen accumulation occurs in the heart still needs to be elucidated but recent studies in humans and animal models of cardiac fibrosis indicate a significant role for inflammation. The proposed studies are to address this issue and how to regulate inflammation in the heart to suppress cardiac fibrosis, using immune cells called regulatory T cells that suppress inflam ....Excessive accumulation of collagen in the heart, cardiac fibrosis is a major factor causing heart failure and sudden death. How collagen accumulation occurs in the heart still needs to be elucidated but recent studies in humans and animal models of cardiac fibrosis indicate a significant role for inflammation. The proposed studies are to address this issue and how to regulate inflammation in the heart to suppress cardiac fibrosis, using immune cells called regulatory T cells that suppress inflammation.Read moreRead less