Stroke Induced Disturbances In Glymphatic Clearance: Implications For Brain Repair?
Funder
National Health and Medical Research Council
Funding Amount
$491,688.00
Summary
We have made a remarkable discovery that the ability of the brain to clear waste proteins is significantly impaired after stroke. This may have important implications for development of dementia and milder changes in thinking late after stroke. We already have some clues regarding potential mechanisms. In this project we will further investigate these mechanisms and their effects on the brain and develop our understanding of potential ways to reverse the clearance problem to develop treatments.
Restoring Microcirculatory Perfusion In ST-elevation Myocardial Infarction: The RESTORE MI Study
Funder
National Health and Medical Research Council
Funding Amount
$3,274,537.00
Summary
Current heart attack treatments have focussed on re-opening the blocked coronary artery but despite this, many patients still suffer significant heart damage because of inadequate blood flow to the heart muscle due to damage to the small blood vessels - the microcirculation. This study seeks to identify heart attack patients with damage to the microcirculation and will conduct a randomised trial of clot busting medications to reduce microcirculation damage and to improve heart function.
Defining Therapeutic Cells As Well As Establishing Cell Targeting And Tracking Technology For The Treatment Of Myocardial Infarction And Atherosclerosis.
Funder
National Health and Medical Research Council
Funding Amount
$664,611.00
Summary
Regenerative cell therapy holds great promise for many diseases. However, studies so far such as preventing and treating heart attacks, often showed limited success. We will address the current three limitations of regenerative cell therapy: 1) Identify the beneficial “therapeutic” cell type. 2) Develop a technology that selectively delivers cells to the area of need. 3) Develop cell tracking technology. This study has the potential to provide major advances in regenerative cell therapy.
Autoimmune Rheumatic Disease And Outcomes After Acute Myocardial Infarction
Funder
National Health and Medical Research Council
Funding Amount
$151,214.00
Summary
Patients with inflammatory arthritis have an increased risk of heart disease and may have worse outcomes after heart attack than the general population. This research project looks at the risk of death after heart attack in people with inflammatory arthritis. This project also compares the treatment that people with arthritis receive after a heart attack with the treatment provided to the general population.
Heparin-induced Thrombocytopenia And Thrombosis: Better Understanding Of Pathogenesis And Improving Diagnosis And Treatment
Funder
National Health and Medical Research Council
Funding Amount
$653,137.00
Summary
Heparin, a widely used drug, can cause an adverse effect which results in a fall of the platelet count and the development of serious thrombosis. This drug complication is mediated by an immune mechanism. This proposal aims to provide a better understanding of the disease mechanism. It also aims to develop a new test that will improve the diagnosis, and to produce a novel drug that will effectively suppress the immune reaction and improve the treatment.
Sex Disparities In Management Of Myocardial Infarction
Funder
National Health and Medical Research Council
Funding Amount
$624,203.00
Summary
We propose using linked routine Big Data from the NSW health system to investigate sex differences in medications prescribed following a first MI, including deviances from guideline recommendations. We will also quantify differences between women and men in subsequent adverse outcomes, such as recurrent MI, according to treatment prescribed, and will study variations in sex dif
A Randomised Evaluation Of The Appropriateness Of Anatomic Coronary Investigation In Cardiac Injury/MI Type 2
Funder
National Health and Medical Research Council
Funding Amount
$2,516,561.00
Summary
Myocardial infarction occurring in the context of another concurrent illness is associated with a higher morbidity, and mortality than patients presenting with spontaneous myocardial infarction. Significant variation in the use of coronary angiography for the investigation of these patients exists, and currently no trial evidence or guidelines define best practice. This trial will establish the optimal investigation and treatment approaches for the care of this very common clinical condition.
Degradable Nanocapsules For Thromboprophylaxis And Treatment Of Acute Thrombosis
Funder
National Health and Medical Research Council
Funding Amount
$1,158,447.00
Summary
The consequences of fat build up in vessels such as heart attacks and brain infarcts are the major cause of death in Australia. Clot busters have been proven to be beneficial for patients with heart attacks, clots in the legs or lungs and brain infarcts. However, the currently available drugs have major limitations in efficacy and in safety. The aim of this project is to develop novel drugs that have the potential to improve both significantly.
Nanoparticle And Virus Assisted Targeting Of MicroRNA And DNA For The Treatment Of Atherosclerosis, Myocardial Infarction And Other Inflammatory Diseases
Funder
National Health and Medical Research Council
Funding Amount
$663,583.00
Summary
Inflammation is an underling cause or aggravating factor of many diseases, such as heart attack and atherosclerosis, but there is a lack of effective anti-inflammatory drugs that do not cause side effects. Using advanced biotechnology, we will use viruses and nanoparticles to selectively target gene therapeutics to areas of inflammation, resulting in high efficacy with low side effects. We will test these broadly usable therapeutics in mouse models of heart attack and atherosclerosis.
Targeted Direct Reprogramming Of Adult Cardiac Fibroblasts To Functional Cardiomyocytes
Funder
National Health and Medical Research Council
Funding Amount
$618,493.00
Summary
Ischemic Heart Disease (IHD) is the leading cause of mortality in Australia, accounting for ~ 22,000 Australians each year. Regenerating a damaged heart remains a major challenge, requiring us to rethink the problem and develop new innovative and readily translatable strategies. This proposal will develop a targeted, cell-free approach to directly reprogram resident cardiac fibroblasts into functional cardiomyocytes post a heart attack, paving the way for a new therapy for IHD sufferers.