It is feasible to sequence patient genomes but we need to know more about how genetic variants cause complex disease. We have sequenced genomes from patients with immune deficiency and will test the idea that genetic variation causes consistent changes in particular white blood cells, thus providing a bridge between genomic information and clinical diagnosis. Outcomes will include more accurate diagnosis, better understanding of immunity, and a strategy for using whole genome information.
RNAi Therapeutic Intervention Of Human Viral Respiratory Disease
Funder
National Health and Medical Research Council
Funding Amount
$584,117.00
Summary
Human metapneumovirus (HMPV), causes clinical disease that is very similar to human respiratory syncytial virus (RSV) and co-circulates with RSV. HMPV is emerging as a major cause of morbidity and life-threatening respiratory tract disease in infants, young children and the elderly worldwide. No treatment is currently available. The objectives of this proposal are to develop novel antiviral drugs that silence the expression of viral genes and to examine protection against the disease.
A Transmission-Blocking Vaccine To Prevent Toxoplasmosis
Funder
National Health and Medical Research Council
Funding Amount
$850,225.00
Summary
Toxoplasma gondii causes a globally important zoonotic disease. It is transmitted by cats, and finds its way into our food chain via infected meat and contaminated water. We have used a unique functional genomics pipeline to discover proteins crucial for reproduction of Toxoplasma in the cat. We will now test combinations of these proteins to immunise cats and prove that we can develop a vaccine that blocks transmission of this highly significant parasitic disease.
Mechanism/s Of Disease Caused By Respiratory Viral Infections
Funder
National Health and Medical Research Council
Funding Amount
$479,517.00
Summary
A newly discovered respiratory virus, human metapneumovirus (HMPV), causes clinical disease that is very similar to human respiratory syncytial virus (RSV) and co-circulates with RSV. Human RSV is a major cause of morbidity and life-threatening respiratory tract disease in infants and young children worldwide, and is recognised as an important respiratory pathogen in elderly adults and immune compromised patients. The recent isolation of HMPV from children hospitalised with respiratory tract ill ....A newly discovered respiratory virus, human metapneumovirus (HMPV), causes clinical disease that is very similar to human respiratory syncytial virus (RSV) and co-circulates with RSV. Human RSV is a major cause of morbidity and life-threatening respiratory tract disease in infants and young children worldwide, and is recognised as an important respiratory pathogen in elderly adults and immune compromised patients. The recent isolation of HMPV from children hospitalised with respiratory tract illness similar to RSV, but with an unknown etiology, suggests that HMPV may mediate similar clinical pathology. Nothing is currently known about the immune response to HMPV, or the association of these responses with lung disease. The objectives of this proposal are to elucidate the mechanisms of immunity and disease pathogenesis associated with human metapneumovirus (HMPV) and to investigate the use of a novel vaccine to protect against HMPV infection. Once this data is obtained, the study will provide the foundation for further research in the development of vaccines or therapeutic protocols to treat HMPV. It will also provide valuable information for understanding the disease in humans. Also,it is likely that HMPV, like hRSV, may prove to be an agent associated with long-term decreased pulmonary function and airflow limitation perhaps developing to asthma.Read moreRead less
Inhibition Of IFN-?/? By Human Metapneumovirus And The Induction Of Inflammation
Funder
National Health and Medical Research Council
Funding Amount
$605,251.00
Summary
The newly isolated human metapneumovirus (hMPV) causes significant respiratory illness in infants, young children and the elderly. The virus can persist long-term and may predispose individuals to chronic lung disease. This proposal aims to determine the mechanisms by which hMPV infection causes respiratory disease, with a view to improving treatments and preventing disease.
Review the preconditions and the underpinning industry and government structures necessary for the successful implementation of co management Objectives: 1. To investigate the resilience of the various co-management approaches to a changing fishing operational environment (biophysical and socio-governance) 2. To look at the lessons learnt, and the challenges arising from, the implementation of co-management in all jurisdictions; with a view to identifying positive and negati ....Review the preconditions and the underpinning industry and government structures necessary for the successful implementation of co management Objectives: 1. To investigate the resilience of the various co-management approaches to a changing fishing operational environment (biophysical and socio-governance) 2. To look at the lessons learnt, and the challenges arising from, the implementation of co-management in all jurisdictions; with a view to identifying positive and negative drivers 3. To assess the skill sets needed to successfully implement co-management 4. To assess how to resource co-management once the fishery has moved past the RD&E phase 5. To identify the relevant RD&E questions to inform future investment 6. To document recommendations for the future implementation of co management Read moreRead less
Managing human resources in an advanced economy from the perspective of emerging Chinese multinationals: the case of NWII in Australia. This project will investigate human resource management practices in the resources sector in Australia and China. The outcomes of this study will provide important theoretical and operational insights into Chinese foreign direct investment for stakeholders such as the Australian government, community, employees and their representatives.
Aquatic Animal Health Subprogram: Technical Guidelines For The Translocation Of Live Aquatic Animals
Funder
Fisheries Research and Development Corporation
Funding Amount
$18,000.00
Summary
There is an existing National Policy for the Translocation of Live Aquatic Organisms. published by the Ministerial Council of Forestry, Fisheries and Aquaculture (1999). This provides the policy basis for translocation within Australia. Industry concern about the practical processes for achieving translocation approval lead to the funding of FRDC 2002/080. In addition, recent concern among jurisdictions over VER outbreaks has emphasised the need to develop technical guidelines to underpin test ....There is an existing National Policy for the Translocation of Live Aquatic Organisms. published by the Ministerial Council of Forestry, Fisheries and Aquaculture (1999). This provides the policy basis for translocation within Australia. Industry concern about the practical processes for achieving translocation approval lead to the funding of FRDC 2002/080. In addition, recent concern among jurisdictions over VER outbreaks has emphasised the need to develop technical guidelines to underpin testing, as well as policy guidelines, for finfish. Objectives: 1. To progress a common approach to the translocation of live finfish across Australia for aquaculture and restocking purposes. Read moreRead less
Mechanisms Of Induction And Progression Of Childhood Asthma: Investigations In A Mouse Model
Funder
National Health and Medical Research Council
Funding Amount
$517,586.00
Summary
This project investigates how certain respiratory viral infections in very young children might predispose to developing asthma, and how inflammation in the airways in asthma might then worsen. The experimental work, which will use unique mouse models developed in the laboratories of the chief investigators, will focus on changes in genes that control the pattern of immune response to allergens and that regulate the progression of inflammation.