Signalling pathways for sexual differentiation of apicomplexan parasites. This project aims to study the sexual development of apicomplexan parasites, which cause major diseases in humans, livestock and wildlife, including malaria. Only sexually differentiated cells can survive in the mosquito vector and hence this development is essential for the parasite's life-cycle. This project will employ a new approach that separates female from male parasites, thus enabling new information to be gleaned ....Signalling pathways for sexual differentiation of apicomplexan parasites. This project aims to study the sexual development of apicomplexan parasites, which cause major diseases in humans, livestock and wildlife, including malaria. Only sexually differentiated cells can survive in the mosquito vector and hence this development is essential for the parasite's life-cycle. This project will employ a new approach that separates female from male parasites, thus enabling new information to be gleaned about the development of these parasites. The expected outcomes are an understanding of the mechanisms of sexual differentiation and a functional characterisation of novel sex-specific molecules. This will provide significant benefits, such as pivotal prerequisites for new approaches to parasite intervention.Read moreRead less
Integrated Planning for Uncertainty-Centric Pilot Assistance Systems. This project aims to deliver a novel pilot assistance system to improve the viability, speed and safety of Helicopter Emergency Medical Services (HEMS) and Search and Rescue (SAR) missions. It will advance fundamental algorithms for probabilistic planning in partially observable scenarios to form the core technology of a pilot assistance system that accounts the various types of uncertainty faced by pilots in a typical HEMS/S ....Integrated Planning for Uncertainty-Centric Pilot Assistance Systems. This project aims to deliver a novel pilot assistance system to improve the viability, speed and safety of Helicopter Emergency Medical Services (HEMS) and Search and Rescue (SAR) missions. It will advance fundamental algorithms for probabilistic planning in partially observable scenarios to form the core technology of a pilot assistance system that accounts the various types of uncertainty faced by pilots in a typical HEMS/SAR missions. It will exploit recent advances in Partially Observable Markov Decision Processes (POMDPs) to recommend robust, safe, and pilot-aware mission and manoeuvring strategies to make HEMS/SAR operations safer for helicopter crews, and more effective for those in need of the service.Read moreRead less