Targeting A Bacterial Glyco-Achilles Heel To Make New Vaccines For Haemophilus Influenzae And Neisseria Gonorrhoeae.
Funder
National Health and Medical Research Council
Funding Amount
$526,950.00
Summary
The bacteria that cause gonorrhoea (N. gonorrhoeae), middle ear infections and exacerbations of chronic obstructive lung disease (H. influenzae) have become multi-drug resistant. These diseases are a major health and economic burden. In the absence of new drugs, a vaccine to prevent these diseases has emerged as a major unmet need in human health. In this grant, we will develop a new vaccine that targets a bacterial-specific sugar that we have discovered is the Achilles heel of these bacteria.
Advancing Enhanced Biosecurity Of Major Arboviral And Other Vector-borne Diseases In Australia Through Near Infrared Spectroscopy Technology
Funder
National Health and Medical Research Council
Funding Amount
$754,983.00
Summary
Infectious diseases transmitted by mosquitoes and ticks represent a significant health threat to the Australian biosecurity. Current detection methods for these pathogens are expensive, time consuming and require highly trained personnel. We propose to conduct a set of experiments to test an innovative, real time technique based on infrared light to identify infected mosquitoes and ticks and demonstrate its capacity as surveillance tool for vector control programs against these pathogens.
Virulence Associated Small RNAs In Acinetobacter Baumannii
Funder
National Health and Medical Research Council
Funding Amount
$964,148.00
Summary
This proposal aims to understand how a superbug that causes severe infections in hospitalised patients worldwide and is known to be resistant to almost all available antibiotics, causes disease. We then plan on using this information to guide the development of a new type of therapy to treat this severe infection.