Detection and viability of waterborne pathogens using a gut-on-chip. This project aims to resolve a significant problem for water utilities. Microbial pathogens Cryptosporidium, norovirus and adenovirus are the main public health concern for drinking water in developed nations. Water monitoring is limited by the lack of fast, reliable detection methods and viability assays for these pathogens. This project will use a novel gut-on-a-chip to develop for the first time rapid infectivity assays for ....Detection and viability of waterborne pathogens using a gut-on-chip. This project aims to resolve a significant problem for water utilities. Microbial pathogens Cryptosporidium, norovirus and adenovirus are the main public health concern for drinking water in developed nations. Water monitoring is limited by the lack of fast, reliable detection methods and viability assays for these pathogens. This project will use a novel gut-on-a-chip to develop for the first time rapid infectivity assays for Cryptosporidium, norovirus and adenovirus. Significant benefits include improved diagnostics and water disinfection assays, improved water treatment and reduced costs with global impact.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC220100050
Funder
Australian Research Council
Funding Amount
$4,508,426.00
Summary
ARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance (ARC CEA-StAR). The ARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance aims to develop industry-led solutions and train a new generation of researchers to combat the impact of antimicrobial resistance (AMR) on agribusiness and the environment.
AMR is a global health and economic threat that epitomises the need for a ‘One Health’ collaborative approach encompassi ....ARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance (ARC CEA-StAR). The ARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance aims to develop industry-led solutions and train a new generation of researchers to combat the impact of antimicrobial resistance (AMR) on agribusiness and the environment.
AMR is a global health and economic threat that epitomises the need for a ‘One Health’ collaborative approach encompassing the interconnection between people, animals, plants, and their shared environment.
Expected outcomes of this collaborative program include a cohort of researchers trained in industry-relevant techniques, furnishing solutions to partner-defined AMR challenges, and providing significant benefits by positioning Australia as a global leader in reducing AMR.Read moreRead less
Unravelling cell wall polysaccharide biosynthesis in pathogenic zygomycetes. This project aims to define mechanisms that control cell wall composition and stability in Rhizopus oryzae, a zygomycete fungus responsible for life-threatening human infections. The biochemical properties and function of vital enzymes involved in a newly discovered cell wall polysaccharide biosynthetic pathway will be determined using innovative approaches at the interface of biochemistry, microbiology, cell biology an ....Unravelling cell wall polysaccharide biosynthesis in pathogenic zygomycetes. This project aims to define mechanisms that control cell wall composition and stability in Rhizopus oryzae, a zygomycete fungus responsible for life-threatening human infections. The biochemical properties and function of vital enzymes involved in a newly discovered cell wall polysaccharide biosynthetic pathway will be determined using innovative approaches at the interface of biochemistry, microbiology, cell biology and structural biology. Expected outcomes include new knowledge on the enzymes that synthesise major fucose-based carbohydrates, to guide the future development of novel strategies for antifungal therapies. The data will also be applicable to animal protection from related zygomycete pathogens.
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Solid Oxide Electrolysis Cells with Novel Perovskite-based Cathode. The electrochemical reduction of CO2 and steam to value-added fuels in a high-temperature solid oxide electrolysis cell (SOEC) is practically promising, but technologically challenging. This project aims to develop next generation SOECs using a perovskite-based cathode and scale-up engineering for rapid, bulk production of H2, CO and syngas fuels. Expected outcomes include material engineering, new knowledge on energy conversion ....Solid Oxide Electrolysis Cells with Novel Perovskite-based Cathode. The electrochemical reduction of CO2 and steam to value-added fuels in a high-temperature solid oxide electrolysis cell (SOEC) is practically promising, but technologically challenging. This project aims to develop next generation SOECs using a perovskite-based cathode and scale-up engineering for rapid, bulk production of H2, CO and syngas fuels. Expected outcomes include material engineering, new knowledge on energy conversion technology, and advanced manufacturing technologies. The success of the project will provide a practical solution to reduce fossil CO2 emissions and potential technology for hydrogen production. These will significantly aid Australia in important climate goals and ambitions.Read moreRead less
Revealing molecular detail of DNA triplexes to underpin antigene technology. Variations from the classic DNA double helix structure are proposed to play key roles in a range of cellular processes, particularly gene regulation. However, the biological function and therapeutic potential of these unusual DNA structures are poorly explored, since the fundamental molecular details which govern their formation and interactions with cellular machinery are not well described. This project aims to develo ....Revealing molecular detail of DNA triplexes to underpin antigene technology. Variations from the classic DNA double helix structure are proposed to play key roles in a range of cellular processes, particularly gene regulation. However, the biological function and therapeutic potential of these unusual DNA structures are poorly explored, since the fundamental molecular details which govern their formation and interactions with cellular machinery are not well described. This project aims to develop innovative methods to investigate, and importantly modulate, DNA and RNA triple helix assembly, specificity and molecular interactions. Resulting insights will underpin novel approaches to gene regulation, principally in the context of designing new antibacterial agents to address the antibacterial resistance problem.Read moreRead less
Controllable Synthesis of Defects in Catalysts for Electrocatalysis . This project aims to address the most critical issue of electrocatalysis: identification of active sites for carbon-based metal free catalysts (CMFCs). Through the development of new methodologies, this proposal will, for the first time, controllably synthesise the vacancy defects that are the major active sites for CMFCs. The expected outcomes from this project include in-depth understanding of the fundamentals of electrocata ....Controllable Synthesis of Defects in Catalysts for Electrocatalysis . This project aims to address the most critical issue of electrocatalysis: identification of active sites for carbon-based metal free catalysts (CMFCs). Through the development of new methodologies, this proposal will, for the first time, controllably synthesise the vacancy defects that are the major active sites for CMFCs. The expected outcomes from this project include in-depth understanding of the fundamentals of electrocatalysis: the reactivity of active sites and the catalytic performance with the number of active sites; which will not only significantly advance knowledge but also achieve breakthrough technologies that greatly benefit to the society and economy both for Australia and worldwide.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100016
Funder
Australian Research Council
Funding Amount
$3,123,492.00
Summary
ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therap ....ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therapeutics. The use of an individual patient’s cellular and molecular research findings will ultimately enable personalised diagnostic and therapeutic decisions.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100109
Funder
Australian Research Council
Funding Amount
$240,000.00
Summary
Raman Spectroscopic System for In-Operando Electrochemical Studies. This proposal aims to establish a Raman microscopic system with real-time tracking capability, which will allow investigation of the activities of battery components during charging. An instrument that allows this level of interrogation is currently not available in Australia. Expected outcomes include advanced knowledge for improved battery technology, which will meet the increasing demand of electronic applications and provide ....Raman Spectroscopic System for In-Operando Electrochemical Studies. This proposal aims to establish a Raman microscopic system with real-time tracking capability, which will allow investigation of the activities of battery components during charging. An instrument that allows this level of interrogation is currently not available in Australia. Expected outcomes include advanced knowledge for improved battery technology, which will meet the increasing demand of electronic applications and provide commercial opportunities in Australia. This system will be highly versatile and extendable to other fields of energy and materials-related research, providing high-quality training of researchers, as well as a platform from which to enhance materials research capabilities in Australia.Read moreRead less