Biomarkers To Define The Treatment End-point For Pulmonary Exacerbations In Cystic Fibrosis
Funder
National Health and Medical Research Council
Funding Amount
$1,031,371.00
Summary
Sensitive and reliable tests are required to monitor lung disease severity in cystic fibrosis. A number of potential methods have emerged in recent years. We will investigate how these tests track an acute episode of lung disease and determine whether, following a typical course of treatment, there is evidence of residual damage that contributes to overall progression of lung disease.
Blocking IL-6 Trans-signaling: A Therapeutic Strategy To Prevent Metabolic Disease
Funder
National Health and Medical Research Council
Funding Amount
$540,636.00
Summary
It is well known that blocking the recruitment of specific immune cells namely macrophages to adipose tissue of obese patients will improve their metabolic health. However, to date, a viable drug to do this has remained elusive. We have developed such a drug called sgp130Fc. This project will test the effectiveness of this drug in a pre-clinical setting.
Influence Of In Utero Environment On Diaphragm Structure And Function
Funder
National Health and Medical Research Council
Funding Amount
$494,966.00
Summary
The diaphragm is the major muscle involved in breathing. Normal function of the diaphragm is essential to survival. Preterm babies may be exposed to infection and other agents that interfere with diaphragm development and make breathing efforts weaker after birth, potentially leading to respiratory failure. This study will study diaphragms of preterm lambs to determine how fetal exposure to infection and steroids affect fetal diaphragm development, and if adverse effects are prevented by fetal t ....The diaphragm is the major muscle involved in breathing. Normal function of the diaphragm is essential to survival. Preterm babies may be exposed to infection and other agents that interfere with diaphragm development and make breathing efforts weaker after birth, potentially leading to respiratory failure. This study will study diaphragms of preterm lambs to determine how fetal exposure to infection and steroids affect fetal diaphragm development, and if adverse effects are prevented by fetal treatment with blocking agents.Read moreRead less