Improving Treatment Strategies For Chronic Alphaviral Arthritic Diseases
Funder
National Health and Medical Research Council
Funding Amount
$643,624.00
Summary
Chikungunya virus and Ross River virus cause epidemics of acute and chronic arthritic disease in humans, which is often poorly managed with current treatments. This grant seeks to understand the mechanisms that give rise to disease in order to identify improved treatment strategies. Both the persistence of viral replication in joint tissues and unnecessary inflammatory responses appear to be important factors driving chronic disease.
Targeting the host lipid environment to disrupt malaria transmission. This project aims to characterise host molecules (in particular lipids) that are crucial for the transition of malaria parasites from one host to another. Malaria parasites encounter different environments upon their transition from human to the mosquito host. This project expects to generate new knowledge on physiological changes that are triggered by particular differences in micronutrient abundance that allow the parasites ....Targeting the host lipid environment to disrupt malaria transmission. This project aims to characterise host molecules (in particular lipids) that are crucial for the transition of malaria parasites from one host to another. Malaria parasites encounter different environments upon their transition from human to the mosquito host. This project expects to generate new knowledge on physiological changes that are triggered by particular differences in micronutrient abundance that allow the parasites to survive in the new host. Anticipated outcomes include the identification of new intervention strategies and improved transmission model systems for vector-borne diseases. This gained knowledge could provide benefits to future biomedical applications by informing diagnostics or treatment of lipid associated diseases.Read moreRead less
Iron sources and cycling in the Tasman Sea. Determining factors that influence the health and vitality of coastal and open-ocean regions is crucial to maintaining marine biodiversity and the Earth's climatic balance. This research project will determine the role iron plays in influencing phytoplankton growth, which ultimately regulates the drawdown of carbon dioxide by the oceans.
Eddy-resolving global ocean-sea ice modelling. Eddy-resolving global ocean-sea ice modelling. This project aims to develop a world-class global ocean-sea ice model framework through a nationwide consortium. The resulting high resolution models are expected to provide the foundation for the next decade of Australian ocean-sea ice modelling capacity. This research should lead to improved ocean and sea ice prediction, ocean reanalyses, and climate projections, enhancing Australia's capacity to pred ....Eddy-resolving global ocean-sea ice modelling. Eddy-resolving global ocean-sea ice modelling. This project aims to develop a world-class global ocean-sea ice model framework through a nationwide consortium. The resulting high resolution models are expected to provide the foundation for the next decade of Australian ocean-sea ice modelling capacity. This research should lead to improved ocean and sea ice prediction, ocean reanalyses, and climate projections, enhancing Australia's capacity to predict the ocean state on timescales of days to decades. This is expected to yield efficiencies in shipping, marine search and rescue and naval operations, and increase the accuracy of projected future changes in climate, sea level, ocean ecosystems and the cryosphere.Read moreRead less
Building Australia's next-generation ocean-sea ice model. Ocean and sea ice models are used for predicting future ocean and climate states, and for climate process research. This project aims to bring the next generation of ocean-sea ice models to Australia and configure the models for our local priorities. The ultimate goal is to create a new coupled ocean-sea ice model for Australia that includes surface waves and biogeochemistry. The model will be optimised and evaluated on Australian facilit ....Building Australia's next-generation ocean-sea ice model. Ocean and sea ice models are used for predicting future ocean and climate states, and for climate process research. This project aims to bring the next generation of ocean-sea ice models to Australia and configure the models for our local priorities. The ultimate goal is to create a new coupled ocean-sea ice model for Australia that includes surface waves and biogeochemistry. The model will be optimised and evaluated on Australian facilities, and released for community use. These developments underpin future ocean state forecasts, sea ice forecasts, wave forecasts, decadal climate prediction and climate process studies. The project will benefit search and rescue, Defence and shipping operations, and will enhance future climate projections.Read moreRead less
Improving water quality modelling by better understanding solute transport. Poor stream water quality is a critical problem in Australia and globally. Stream water quality depends directly on pathways and time taken for water to transport pollutants through catchments. Predicting these pathways is highly challenging and currently requires specialised data. This project aims to better model the movement of water from rainfall to streams, enable greatly improved use of water quality data routinely ....Improving water quality modelling by better understanding solute transport. Poor stream water quality is a critical problem in Australia and globally. Stream water quality depends directly on pathways and time taken for water to transport pollutants through catchments. Predicting these pathways is highly challenging and currently requires specialised data. This project aims to better model the movement of water from rainfall to streams, enable greatly improved use of water quality data routinely collected in Australia's catchments and thereby better predict water quality behaviour. Proposed field studies aim to support this development. The outcomes sought are improved planning and management of water quality in our rivers, lakes and estuaries, improved health of these water bodies and improved water supplies.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668345
Funder
Australian Research Council
Funding Amount
$390,700.00
Summary
A highly sensitive mass spectrometer for trace analysis of biomarker molecules to study changes in recent and ancient environments. Maintaining the quality of water and soil is a critically important issue for Australia's economic and social development. To be able to predict and plan the future of our natural assets, it is critical to understand their ecological past and their state before and after European settlement. We will utilize the new instrument to develop and apply innovative technolo ....A highly sensitive mass spectrometer for trace analysis of biomarker molecules to study changes in recent and ancient environments. Maintaining the quality of water and soil is a critically important issue for Australia's economic and social development. To be able to predict and plan the future of our natural assets, it is critical to understand their ecological past and their state before and after European settlement. We will utilize the new instrument to develop and apply innovative technologies providing Australia with new knowledge about the causes and effects of toxic cyanobacterial blooms, eutrophication, and contamination of reservoirs by bush-fires. The new facility will also supply advanced oil fingerprinting techniques to the petroleum industry minimizing exploration risk and increasing the chance of the discovery of new oil deposits.Read moreRead less
Special Research Initiatives - Grant ID: SR0354797
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
The Australian Tissue Engineering Network. Driven by four key nodes across the country, the Initiative aims to bring together geographically and financially separated groups into a critical mass of cell and tissue engineering research. This new and rapidly-growing field uses a bio-synthetic approach to replace, repair or regenerate damaged tissues and organs. The Initiative will build the framework which will enable the Network to: identify appropriate expertise, manage duplication, enhance co ....The Australian Tissue Engineering Network. Driven by four key nodes across the country, the Initiative aims to bring together geographically and financially separated groups into a critical mass of cell and tissue engineering research. This new and rapidly-growing field uses a bio-synthetic approach to replace, repair or regenerate damaged tissues and organs. The Initiative will build the framework which will enable the Network to: identify appropriate expertise, manage duplication, enhance communication, bring together innovative skill sets, create linkages, generate focussed research programs and foster novel commercial opportunities. Ultimately the Initiative and Network will deliver an improved quality of life, reduced healthcare costs, and increased productivity to Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560956
Funder
Australian Research Council
Funding Amount
$397,100.00
Summary
World-leading elemental and isotopic microanalysis and chemical speciation facilities for an environmentally sustainable Australia. We propose to establish a world-leading centre for the study of the elemental and isotopic composition of key environmental, archaeological and mineral samples. This will be based upon ultra-short wavelength laser ablation and speciation methods, combined with new advanced ICP-MS technologies developed in Australia. This will give the centre unrivalled capabilities ....World-leading elemental and isotopic microanalysis and chemical speciation facilities for an environmentally sustainable Australia. We propose to establish a world-leading centre for the study of the elemental and isotopic composition of key environmental, archaeological and mineral samples. This will be based upon ultra-short wavelength laser ablation and speciation methods, combined with new advanced ICP-MS technologies developed in Australia. This will give the centre unrivalled capabilities and allow new areas of research to be undertaken in global climate change, the impact of increased salinity and pollution on the sustainability of Australia's inland waterways and coastal environments, and the history of the first humans who inhabited Australia. This will provide a baseline and new quantitative measures to better plan for an environmentally sustainable Australia.Read moreRead less