Improving Treatment Strategies For Chronic Alphaviral Arthritic Diseases
Funder
National Health and Medical Research Council
Funding Amount
$643,624.00
Summary
Chikungunya virus and Ross River virus cause epidemics of acute and chronic arthritic disease in humans, which is often poorly managed with current treatments. This grant seeks to understand the mechanisms that give rise to disease in order to identify improved treatment strategies. Both the persistence of viral replication in joint tissues and unnecessary inflammatory responses appear to be important factors driving chronic disease.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989608
Funder
Australian Research Council
Funding Amount
$190,000.00
Summary
The Heron Island Climate Change Observatory: An In-Situ Ocean Acidification and Carbonate Chemistry Monitoring Platform. Climate change and ocean acidification are widely recognized as key threats to Australia's natural ecosystems, yet we are currently ill-equipped to respond due to poor knowledge of the scale/nature of the impacts. The Heron Island Climate Change Observatory will establish key infrastructure that will rapidly improve our understanding of the impacts of ocean acidification whic ....The Heron Island Climate Change Observatory: An In-Situ Ocean Acidification and Carbonate Chemistry Monitoring Platform. Climate change and ocean acidification are widely recognized as key threats to Australia's natural ecosystems, yet we are currently ill-equipped to respond due to poor knowledge of the scale/nature of the impacts. The Heron Island Climate Change Observatory will establish key infrastructure that will rapidly improve our understanding of the impacts of ocean acidification which is important to local communities and the nation given that coral reefs support over $6 billion in revenue (and employ 60,000 people) each year. This critically important information is essential to the management and protection of Australia's coral reefs, including the Great Barrier Reef.
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Assessing risk of oligomictic conditions in sub-tropical water supply lakes. Assessing risk of oligomictic conditions in sub-tropical water supply lakes. This project aims to assess the risk of low rates of mixing in sub-tropical drinking water supply reservoirs, using environmental monitoring and numerical modelling. Emerging evidence suggests sub-tropical drinking water supply reservoirs could transition to low mixing states with increasing age and projected changes in global climate. While th ....Assessing risk of oligomictic conditions in sub-tropical water supply lakes. Assessing risk of oligomictic conditions in sub-tropical water supply lakes. This project aims to assess the risk of low rates of mixing in sub-tropical drinking water supply reservoirs, using environmental monitoring and numerical modelling. Emerging evidence suggests sub-tropical drinking water supply reservoirs could transition to low mixing states with increasing age and projected changes in global climate. While this risk is poorly understood, it could significantly affect the long-term reliability of water supply and potable water treatment costs. Addressing this knowledge gap is expected to develop effective management responses to ensure the long term sustainable use of these water resources.Read moreRead less
Special Research Initiatives - Grant ID: SR0354797
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
The Australian Tissue Engineering Network. Driven by four key nodes across the country, the Initiative aims to bring together geographically and financially separated groups into a critical mass of cell and tissue engineering research. This new and rapidly-growing field uses a bio-synthetic approach to replace, repair or regenerate damaged tissues and organs. The Initiative will build the framework which will enable the Network to: identify appropriate expertise, manage duplication, enhance co ....The Australian Tissue Engineering Network. Driven by four key nodes across the country, the Initiative aims to bring together geographically and financially separated groups into a critical mass of cell and tissue engineering research. This new and rapidly-growing field uses a bio-synthetic approach to replace, repair or regenerate damaged tissues and organs. The Initiative will build the framework which will enable the Network to: identify appropriate expertise, manage duplication, enhance communication, bring together innovative skill sets, create linkages, generate focussed research programs and foster novel commercial opportunities. Ultimately the Initiative and Network will deliver an improved quality of life, reduced healthcare costs, and increased productivity to Australia.Read moreRead less
Bubble, Bubble CO2 is the trouble: A Natural Ocean Acidification Experiment in a coral reef setting. Carbon dioxide seep sites expose shallow coral reefs in Papua New Guinea to volcanic carbon dioxide resulting in gradients of seawater ranging from pH 8.0 (normal) to a more acidic pH of 7.5. Some areas of these reefs experience carbon dioxide exposure equivalent to IPCC predictions for 2050 and 2100. This project will reconstruct seawater pH using radiocarbon as a novel tracer of carbon dioxide ....Bubble, Bubble CO2 is the trouble: A Natural Ocean Acidification Experiment in a coral reef setting. Carbon dioxide seep sites expose shallow coral reefs in Papua New Guinea to volcanic carbon dioxide resulting in gradients of seawater ranging from pH 8.0 (normal) to a more acidic pH of 7.5. Some areas of these reefs experience carbon dioxide exposure equivalent to IPCC predictions for 2050 and 2100. This project will reconstruct seawater pH using radiocarbon as a novel tracer of carbon dioxide input at a coral reef site that has been exposed to high carbon dioxide due to volcanic seeps (seep carbon dioxide has no carbon-14) for an unknown period of time (at least many decades, but possibly centuries). These results will help to understand the time it takes to change calcifying organisms into “winners” or “losers” as an analog for Ocean Acidification due to increased atmospheric carbon dioxide input.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560940
Funder
Australian Research Council
Funding Amount
$229,326.00
Summary
Stable Isotope Ratio Mass Spectrometry Facility. This application for a Stable Isotope Ratio Mass Spectrometer Facility provides a focus for research collaboration and training in northern Australia. The Facility will enhance strong collaboration between organisations committed to increasing understanding of unique northern environments, and will include the Arafura Timor Research Facility, a Major National Research Facility. The Facility will contribute to studies of conservation biology, nat ....Stable Isotope Ratio Mass Spectrometry Facility. This application for a Stable Isotope Ratio Mass Spectrometer Facility provides a focus for research collaboration and training in northern Australia. The Facility will enhance strong collaboration between organisations committed to increasing understanding of unique northern environments, and will include the Arafura Timor Research Facility, a Major National Research Facility. The Facility will contribute to studies of conservation biology, natural resource management, environmental and marine science and resource development in the tropical north. It will help develop knowledge bases, innovative approaches to environmental management and sustainable development and high levels of research and research training for regional development.Read moreRead less
Smart management of disinfectant in chloraminated water-supply systems. Smart management of disinfectant in chloraminated water-supply systems. This project aims to develop an adaptive, real-time control system for managing disinfectant residuals in chloraminated water supply systems. While chloramine delivers microbiologically safe drinking water in warmer climates and in long distribution systems, it is largely unpredictable, costs water utilities millions of dollars annually, and has uncertai ....Smart management of disinfectant in chloraminated water-supply systems. Smart management of disinfectant in chloraminated water-supply systems. This project aims to develop an adaptive, real-time control system for managing disinfectant residuals in chloraminated water supply systems. While chloramine delivers microbiologically safe drinking water in warmer climates and in long distribution systems, it is largely unpredictable, costs water utilities millions of dollars annually, and has uncertain benefits. This project’s control system will be guided by quantitative models formulated from multi-pronged, fundamental experiments. The project will quantify microbial chloramine decay and determine mechanisms to increase predictability. The project will develop and demonstrate a real-time control technology which delivered microbiologically safe, cost-efficient drinking water to people in warmer climates, despite warming climate and increasing population.Read moreRead less
Bulk nanobubbles: from fundamentals to biomedical applications. This project aims to extend optical and acoustic tools to detect bulk nanobubbles, control their size-distributions, and understand how they interact with biomolecules. Liquids containing nanobubbles have numerous applications particularly in biomedicine. Using interdisciplinary approaches, this project expects to gain convincing evidence of the existence of bulk nanobubbles. This is expected to advance existing fundamental knowle ....Bulk nanobubbles: from fundamentals to biomedical applications. This project aims to extend optical and acoustic tools to detect bulk nanobubbles, control their size-distributions, and understand how they interact with biomolecules. Liquids containing nanobubbles have numerous applications particularly in biomedicine. Using interdisciplinary approaches, this project expects to gain convincing evidence of the existence of bulk nanobubbles. This is expected to advance existing fundamental knowledge at the forefront of soft matter research, and give Australia a decisive technological head start in a competitive and lucrative industry through patentable technology.Read moreRead less
ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory ne ....ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory networks and to address how environmental factors impinge on these regulatory networks. The formation of this National Research Network is unique, timely and strategic. It will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100159
Funder
Australian Research Council
Funding Amount
$160,000.00
Summary
Mobile Australian field isotope alliance. This project will enable a quantum leap in capacity to undertake, real-time, field-based studies of environmental processes using the natural isotope tracers of carbon, oxygen and hydrogen. This will enable the project to address a range of fundamental research questions in climate change, water resources, ecology and human impact in tropical Australia.