Understanding And Applying Macrophage-mediated Effects On Liver Progenitor Cells To Treat Liver Disease.
Funder
National Health and Medical Research Council
Funding Amount
$628,109.00
Summary
As liver cancer risk correlates with increased liver stem/progenitor cell numbers, therapies that reduce their numbers will reduce cancer development. On the contrary, therapies to increase progenitor cell numbers will assist their use in cell therapy-based approaches or artificial liver devices to treat chronic liver disease. This project will determine how to use inflammatory cells to manipulate progenitor cell numbers.
Improving Treatment Strategies For Chronic Alphaviral Arthritic Diseases
Funder
National Health and Medical Research Council
Funding Amount
$643,624.00
Summary
Chikungunya virus and Ross River virus cause epidemics of acute and chronic arthritic disease in humans, which is often poorly managed with current treatments. This grant seeks to understand the mechanisms that give rise to disease in order to identify improved treatment strategies. Both the persistence of viral replication in joint tissues and unnecessary inflammatory responses appear to be important factors driving chronic disease.
Developmental-associated Dysregulation Of Innate Anti-microbial Immunity In Early Life As A Determinant Of Susceptibility To Atopic Asthma
Funder
National Health and Medical Research Council
Funding Amount
$570,334.00
Summary
Previous NHMRC-sponsored research from the applicants has demonstrated that one of the strongest risk factors for subsequent development of asthma is having chest infections during infancy that are so severe that they trigger symptoms of fever and wheeze. It is not known what predisposes susceptible infants to these severe infections, and this project will attempt to define the mechanisms of susceptibility.
Hydrodynamics of Fringing Reef Systems. This project aims to develop a numerical circulation model applicable to fringing reef systems, in particular, the Ningaloo reef, Western Australia. The model will include the effects of tides, winds, surface gravity waves and density. The model results will be compared to field measurements collected by the Australian Institute of Marine Science. After the model has been developed and validated, it will be used to investigate processes such as water e ....Hydrodynamics of Fringing Reef Systems. This project aims to develop a numerical circulation model applicable to fringing reef systems, in particular, the Ningaloo reef, Western Australia. The model will include the effects of tides, winds, surface gravity waves and density. The model results will be compared to field measurements collected by the Australian Institute of Marine Science. After the model has been developed and validated, it will be used to investigate processes such as water exchange between lagoons and open sea, effects of contaminant spills and recruitment within the reef systems. An understanding of these processes is essential for the sustainable management of these systems.Read moreRead less
Turbulent vertical mixing in stratified flows. The project will provide the first definitive data set to document, at the process level, the contribution of turbulance, to mixing in stratified flows and improve our understanding of how well current closure schemes mimic the buoyancy flux and the Reynolds stresses in a stratified shear flow.
Assessment of the Mass Flux in a Benthic Boundary Layer of a Stratified Lake. Understanding the underlying processes responsible for Benthic Bundary Layer (BBL) mass flux in stratified lakes is of fundamental ecological importance. By verifying the ability of the current Centre for Water Research hydrodynamics models to reproduce the dynamics of the BBL, Australia will cement its position as an international leader in the development of technologies to guide the management of lakes, reservoirs, ....Assessment of the Mass Flux in a Benthic Boundary Layer of a Stratified Lake. Understanding the underlying processes responsible for Benthic Bundary Layer (BBL) mass flux in stratified lakes is of fundamental ecological importance. By verifying the ability of the current Centre for Water Research hydrodynamics models to reproduce the dynamics of the BBL, Australia will cement its position as an international leader in the development of technologies to guide the management of lakes, reservoirs, estuaries and coastal areas. Furthermore, these water bodies are important sources and sinks of carbon and the extent to which they contribute to the national and international carbon inventory can be assessed using this technology.Read moreRead less
MODAL AND DIRECTIONAL CHARACTERISTICS OF SEASTATES AND THEIR IMPACT ON DYNAMICS OF MOORED OFFSHORE SYSTEMS. Under certain conditions a typical sea can becomes bimodal comprising of wind-driven seas and long period swells interacting from two directions. Using a nonlinear model, the occurrence and characteristics of bimodal and bi-directional seastates are quantified.
Low frequency oscillations of a moored offshore structure have profound design influence on the mooring system. A nonlinear res ....MODAL AND DIRECTIONAL CHARACTERISTICS OF SEASTATES AND THEIR IMPACT ON DYNAMICS OF MOORED OFFSHORE SYSTEMS. Under certain conditions a typical sea can becomes bimodal comprising of wind-driven seas and long period swells interacting from two directions. Using a nonlinear model, the occurrence and characteristics of bimodal and bi-directional seastates are quantified.
Low frequency oscillations of a moored offshore structure have profound design influence on the mooring system. A nonlinear response model for a floating vessel in bimodal and bi-directional seastates, will be developed using nonlinear dynamics techniques. The numerical models for the environment and the floating platform will be validated by experiments at the Ocean Basin in Canada.
The project adopts a holistic approach by considering the environment and the moored platform as a complex natural system. With excellent opportunities for technology transfer, the project also benefits from substantial in-kind contributions of the overseas PIs.
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Factors controlling phytoplankton patchiness in a seasonally stratified lake. This project will determine what processes result in the formation of phytoplankton patches in lakes, over what scale, and how they can be parameterized into models to assist in managing aquatic systems. This will allow key parameters to be measured at the correct time and space scales. The Controlled Lagrangian Drogue coupled with correctly parameterized hydrodynamic and water quality models will provide the Austra ....Factors controlling phytoplankton patchiness in a seasonally stratified lake. This project will determine what processes result in the formation of phytoplankton patches in lakes, over what scale, and how they can be parameterized into models to assist in managing aquatic systems. This will allow key parameters to be measured at the correct time and space scales. The Controlled Lagrangian Drogue coupled with correctly parameterized hydrodynamic and water quality models will provide the Australian and International water industry with tools to measure and predict phytoplankton patchiness and make decisions about water quality treatment, offtake regimes and reservoir management. This will minimize the economic costs of water quality management and enhance the security of the quality of our water resources. Read moreRead less
Evaluating the feasibility and effect of using a hospital wide coordinated approach to introduce evidence-based changes for pain management. This project will develop a comprehensive educational program and approach to pain management for public and private hospitals that could be used by other hospitals elsewhere. An educational program for hospitals staff, and specifically for Pain Resource Nurses, will be produced. This project has the potential to minimise the experience of pain and prevent ....Evaluating the feasibility and effect of using a hospital wide coordinated approach to introduce evidence-based changes for pain management. This project will develop a comprehensive educational program and approach to pain management for public and private hospitals that could be used by other hospitals elsewhere. An educational program for hospitals staff, and specifically for Pain Resource Nurses, will be produced. This project has the potential to minimise the experience of pain and prevent widespread complications associated with pain for all hospitalised patients, irrespective of diagnosis or reason for admission. It is also envisaged that this project will establish a model of change that could be used to facilitate evidence-based practice in other aspects of healthcare apart from pain.Read moreRead less
Maximizing reservoir water quality security through the use of a Lake Diagnostic System (LDS) and a Controlled Lagrangian Drogue (CLD). It is proposed to build on recent advancements in limnological research and existing measurement technologies to develop the hardware, algorithms and software to form a unique real time reservoir water quality management system, driven by minimal measurement inputs. This will remove the reliance on extensive expensive reservoir monitoring, previously necessary ....Maximizing reservoir water quality security through the use of a Lake Diagnostic System (LDS) and a Controlled Lagrangian Drogue (CLD). It is proposed to build on recent advancements in limnological research and existing measurement technologies to develop the hardware, algorithms and software to form a unique real time reservoir water quality management system, driven by minimal measurement inputs. This will remove the reliance on extensive expensive reservoir monitoring, previously necessary to characterize the lake spatial variability and seasonality, for full 3D modelling. This project will deliver to industry: two measurement tools to simplify reservoir monitoring, the LDS and CLD; and software tools to manage real time data collection, provide decision support to reservoir managers and to enable ?on-demand? scenario predictions.Read moreRead less