Improving Treatment Strategies For Chronic Alphaviral Arthritic Diseases
Funder
National Health and Medical Research Council
Funding Amount
$643,624.00
Summary
Chikungunya virus and Ross River virus cause epidemics of acute and chronic arthritic disease in humans, which is often poorly managed with current treatments. This grant seeks to understand the mechanisms that give rise to disease in order to identify improved treatment strategies. Both the persistence of viral replication in joint tissues and unnecessary inflammatory responses appear to be important factors driving chronic disease.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668345
Funder
Australian Research Council
Funding Amount
$390,700.00
Summary
A highly sensitive mass spectrometer for trace analysis of biomarker molecules to study changes in recent and ancient environments. Maintaining the quality of water and soil is a critically important issue for Australia's economic and social development. To be able to predict and plan the future of our natural assets, it is critical to understand their ecological past and their state before and after European settlement. We will utilize the new instrument to develop and apply innovative technolo ....A highly sensitive mass spectrometer for trace analysis of biomarker molecules to study changes in recent and ancient environments. Maintaining the quality of water and soil is a critically important issue for Australia's economic and social development. To be able to predict and plan the future of our natural assets, it is critical to understand their ecological past and their state before and after European settlement. We will utilize the new instrument to develop and apply innovative technologies providing Australia with new knowledge about the causes and effects of toxic cyanobacterial blooms, eutrophication, and contamination of reservoirs by bush-fires. The new facility will also supply advanced oil fingerprinting techniques to the petroleum industry minimizing exploration risk and increasing the chance of the discovery of new oil deposits.Read moreRead less
Unravelling the cycling of nitrogen along a subtropical freshwater-marine continuum using a multi-isotope, multi-tracer and modelling approach. This project will significantly advance our understanding of the sources, cycling and pathways of nitrogen along a sub-tropical catchment-river-estuary. As such, the findings from this research will have direct implications to the management, rehabilitation and protection of waterways (including biodiversity) in Australia.
Hyper-accumulations of monosulfidic sediments: Exploring a biogeochemical extreme to resolve fundamental sulfur biomineralisation pathways. The hyper-accumulation of monosulfidic sediments has a directsocial, economic and environmental impact on communities in many parts of Australia, including highly valued wetland systems such as the Ramsar wetlands of the lower Murray Darling Basin and internationally recognised Peel-Harvey Estuary of WA. Maintenance dredging of these materials alone costs th ....Hyper-accumulations of monosulfidic sediments: Exploring a biogeochemical extreme to resolve fundamental sulfur biomineralisation pathways. The hyper-accumulation of monosulfidic sediments has a directsocial, economic and environmental impact on communities in many parts of Australia, including highly valued wetland systems such as the Ramsar wetlands of the lower Murray Darling Basin and internationally recognised Peel-Harvey Estuary of WA. Maintenance dredging of these materials alone costs the nation millions of dollars annually. The hyper monosulfidic sediments are also linked to severe environmental impacts. This project will inform how these materials develop and accumulate. This new knowledge will be of immediate relevance for the management of eutrophic estuaries.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989731
Funder
Australian Research Council
Funding Amount
$700,000.00
Summary
Instrumentation for Innovative Marine Biogeochemistry. Rising greenhouse gases are changing the chemistry of the oceans, by altering the availability of nutrients and causing ocean acidification. Along with local pollutants, these changes pose significant threats to the productivity and sustainability of Australia's marine ecosystems. The proposed instrumentation will support world-leading research into the nature, impact, and potential for mitigating these changes. This will underpin our abilit ....Instrumentation for Innovative Marine Biogeochemistry. Rising greenhouse gases are changing the chemistry of the oceans, by altering the availability of nutrients and causing ocean acidification. Along with local pollutants, these changes pose significant threats to the productivity and sustainability of Australia's marine ecosystems. The proposed instrumentation will support world-leading research into the nature, impact, and potential for mitigating these changes. This will underpin our ability to manage and preserve the environmental, societal and economic values of our coastal and open ocean marine resources.Read moreRead less
Unlocking the secrets of the groundwater cycle using Si and Li isotopes. This project aims to determine how non-conventional lithium and silicon isotopes can be used to understand groundwater processes using an innovative source-to-target approach. The project aims to apply these isotope tracers to trace the water cycle within a well constrained system: an island aquifer with a dense borefield which has been analysed using traditional isotopic techniques. Supporting hydrochemical data will be us ....Unlocking the secrets of the groundwater cycle using Si and Li isotopes. This project aims to determine how non-conventional lithium and silicon isotopes can be used to understand groundwater processes using an innovative source-to-target approach. The project aims to apply these isotope tracers to trace the water cycle within a well constrained system: an island aquifer with a dense borefield which has been analysed using traditional isotopic techniques. Supporting hydrochemical data will be used to determine the relationship of the isotopes with environmental processes. The project impact will be the development of new methods to help understand our groundwater resource. The improved process understanding will be translated to groundwater management in general. The projects' focus on carbonate aquifer systems typical of coastal regions of southern, eastern and western Australia will have relevance to groundwater management in urban areas such as Perth and in rural areas for tourism and viticulture, and for management of natural resources in National Parks.Read moreRead less
Unravelling the drivers of greenhouse gas emissions in estuaries. The aim of this project is to understand and quantify the factors controlling the emission of carbon dioxide, methane and nitrous oxide from estuaries. Coastal systems play a disproportionately large role in the global emissions of greenhouse gases, but this is poorly quantified. The project plans to use a combination of continuous concentration and stable isotope measurements, process measurements and advanced numerical modelling ....Unravelling the drivers of greenhouse gas emissions in estuaries. The aim of this project is to understand and quantify the factors controlling the emission of carbon dioxide, methane and nitrous oxide from estuaries. Coastal systems play a disproportionately large role in the global emissions of greenhouse gases, but this is poorly quantified. The project plans to use a combination of continuous concentration and stable isotope measurements, process measurements and advanced numerical modelling across a range of undisturbed to disturbed systems. It is intended that this project will provide information for conceptualising, calibrating and verifying models, including green-house gas production. Good models, and the data that support them, such as that provided by this study, are critical for the efficient allocation of management resources in Australian coastal systems, including by our partners. The findings from this project will have direct implications to the management, rehabilitation and protection of waterways (including biodiversity) in Australia.Read moreRead less
Advanced water treatment technologies to minimise nitrogenous disinfection by-products in drinking water: understanding the role of organic nitrogen. This project will identify improved methods for treatment of drinking water to prevent the formation of potentially hazardous disinfection by-products. It will assist water resource managers and regulators to select the most economical and safe treatment for each type of water source and to plan for future demands on our limited water supplies.
Electron flow in iron hyper-enriched acidifying coastal environments: reaction paths and kinetics of iron-sulfur-carbon transformations. Iron hyper-enriched acidifying coastal lowlands have a direct social, economic and environmental impact on communities in many parts of Australia. This project will determine how iron transforms and accumulates. The new knowledge will be of immediate relevance for the remediation of coastal plains.
On-line monitoring of cyanobacteria to predict coagulant doses and powdered activated carbon application in water treatment. Cyanobacteria, more commonly known as blue-green algae, can impact water quality by releasing toxins that can be harmful to human health and imparting unpleasant taste and odours to the water. This project will support the water industry in managing these risks by providing a rapid, on-line tool to assist in their removal during water treatment.