Neurobiological mechanisms of the interaction between pain and sleep. The project aims to reveal the brain mechanisms behind the interaction between such fundamental biological phenomena as sleep and pain. This highly interdisciplinary project expects to deliver significant insights into how poor sleep changes the brain to increase pain sensitivity in healthy adults, by combining novel lab-based mechanistic sleep and pain manipulations and naturalistic longitudinal observation. The rich multimod ....Neurobiological mechanisms of the interaction between pain and sleep. The project aims to reveal the brain mechanisms behind the interaction between such fundamental biological phenomena as sleep and pain. This highly interdisciplinary project expects to deliver significant insights into how poor sleep changes the brain to increase pain sensitivity in healthy adults, by combining novel lab-based mechanistic sleep and pain manipulations and naturalistic longitudinal observation. The rich multimodal dataset generated by the project will be made publicly available to enhance research transparency and international collaboration. This should provide significant benefits, ultimately opening up ways to improve quality of life and wellbeing of the Australian population.
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Faecal Microbiota Transplantation And Other Novel Therapeutic Microbial Manipulation Strategies In Inflammatory Bowel Disease
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
There is growing interest in the role of microbial-based strategies including faecal microbiota transplantation (FMT) for the treatment of inflammatory bowel disease. This project will develop such strategies into valid treatment options through a combination of clinical & basic science work including (1) characterising viral & fungal factors of importance, (2) evaluation of novel orally-delivered formulations of FMT, and (3) development of better defined, more reproducible microbial treatments.
Discovery Early Career Researcher Award - Grant ID: DE230100206
Funder
Australian Research Council
Funding Amount
$423,154.00
Summary
Pain: Open to interpretation? This project aims to determine how pain interpretation drives pain experience, using rigorous state-of-the-art lab research. This project expects to generate new knowledge about the psychological mechanisms maintaining pain experience and avoidance behaviour, using novel techniques to measure interpretation of pain sensations. Expected outcomes include the development of an evidence-based psychological model of pain interpretation, enhanced capacity to build interna ....Pain: Open to interpretation? This project aims to determine how pain interpretation drives pain experience, using rigorous state-of-the-art lab research. This project expects to generate new knowledge about the psychological mechanisms maintaining pain experience and avoidance behaviour, using novel techniques to measure interpretation of pain sensations. Expected outcomes include the development of an evidence-based psychological model of pain interpretation, enhanced capacity to build international collaborations, and ecologically valid methods for measuring pain interpretation. This research forms a solid platform for further translational research, to build novel, scalable interventions to improve outcomes for the one in five Australians living with chronic pain.Read moreRead less