Improving Treatment Strategies For Chronic Alphaviral Arthritic Diseases
Funder
National Health and Medical Research Council
Funding Amount
$643,624.00
Summary
Chikungunya virus and Ross River virus cause epidemics of acute and chronic arthritic disease in humans, which is often poorly managed with current treatments. This grant seeks to understand the mechanisms that give rise to disease in order to identify improved treatment strategies. Both the persistence of viral replication in joint tissues and unnecessary inflammatory responses appear to be important factors driving chronic disease.
Non-equilibrium material phases. This project aims to synthesise and characterise exotic materials produced in the laboratory under conditions that replicate those inside planets and stars. Highly non-equilibrium processing methods are needed to find entirely new material forms of elements and compounds created under extreme pressure and temperature. The project will use its laser-based synthesis method to explore and understand the non-equilibrium pathways and develop new materials. Understandi ....Non-equilibrium material phases. This project aims to synthesise and characterise exotic materials produced in the laboratory under conditions that replicate those inside planets and stars. Highly non-equilibrium processing methods are needed to find entirely new material forms of elements and compounds created under extreme pressure and temperature. The project will use its laser-based synthesis method to explore and understand the non-equilibrium pathways and develop new materials. Understanding how these materials form could lead to the next materials revolution. This research will lead to materials that industry sectors can exploit for commercial benefits.Read moreRead less
Plant use at the dawn of agriculture in central Anatolia. The project will increase collaboration with researchers in the UK, and Turkish archaeological authorities. It will refine our understanding of the process, rate and direction of agricultural origins in Western Asia and improve Australia's profile in origins of agriculture research. It will increase Australia's knowledge base about other regions and help to consolidate and promote archaeobotany/archaeological science in Australia's resear ....Plant use at the dawn of agriculture in central Anatolia. The project will increase collaboration with researchers in the UK, and Turkish archaeological authorities. It will refine our understanding of the process, rate and direction of agricultural origins in Western Asia and improve Australia's profile in origins of agriculture research. It will increase Australia's knowledge base about other regions and help to consolidate and promote archaeobotany/archaeological science in Australia's research community.Read moreRead less
Beyond migration and diffusion: The prehistoric mobility of people & ideas. The project plans to build on the strength of current collaborations between archaeologists and geochemists to ask novel questions about the movement of people and ideas in prehistory. The project plans to examine spatial and temporal patterns in population mobility to clarify their relationship with the appearance of new and exotic materials, technologies and practices. The project focuses on the ways in which the movem ....Beyond migration and diffusion: The prehistoric mobility of people & ideas. The project plans to build on the strength of current collaborations between archaeologists and geochemists to ask novel questions about the movement of people and ideas in prehistory. The project plans to examine spatial and temporal patterns in population mobility to clarify their relationship with the appearance of new and exotic materials, technologies and practices. The project focuses on the ways in which the movement of individuals and groups of people is both an instigator and a response to sociocultural change, using both key European and Pacific Island examples, to help build a comparative archaeology of phenomena of rapid social and economic change, with pertinence to general theories of innovation and adoption.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC200100023
Funder
Australian Research Council
Funding Amount
$4,920,490.00
Summary
ARC Training Centre for The Global Hydrogen Economy. The centre aims to transform Australia into a hydrogen powerhouse by building enabling capacity in hydrogen innovation in a short timeframe. Australia is well-positioned to capitalise on the emerging global growth of hydrogen, however to be competitive and produce at scale, we need cost-effective hydrogen technologies and capabilities for transitioning hydrogen into industries. This innovative, five-year program will generate new technologies ....ARC Training Centre for The Global Hydrogen Economy. The centre aims to transform Australia into a hydrogen powerhouse by building enabling capacity in hydrogen innovation in a short timeframe. Australia is well-positioned to capitalise on the emerging global growth of hydrogen, however to be competitive and produce at scale, we need cost-effective hydrogen technologies and capabilities for transitioning hydrogen into industries. This innovative, five-year program will generate new technologies and equip a future workforce of industry-focused engineers with advanced skills for development and scaling-up of hydrogen generation and transport. Benefits include: export of hydrogen fuel and advanced technologies; job creation; and a lower emissions domestic energy industry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100023
Funder
Australian Research Council
Funding Amount
$650,000.00
Summary
Australian high field electron paramagnetic resonance facility. This project aims to establish Australia’s first a high-field (3 T, 94 GHz) high-field pulse electron paramagnetic resonance (EPR) facility. EPR is a powerful technique to study chemical, biological and materials systems. It represents a sensitive, non-invasive, site-selective spectroscopy for the analysis of both molecular and macroscopic properties. This facility will allow the further development and implementation of new multidi ....Australian high field electron paramagnetic resonance facility. This project aims to establish Australia’s first a high-field (3 T, 94 GHz) high-field pulse electron paramagnetic resonance (EPR) facility. EPR is a powerful technique to study chemical, biological and materials systems. It represents a sensitive, non-invasive, site-selective spectroscopy for the analysis of both molecular and macroscopic properties. This facility will allow the further development and implementation of new multidimensional pulse EPR techniques, enabling domestic and international collaborations with diverse applications in structural biology, solvation science and catalysis.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100112
Funder
Australian Research Council
Funding Amount
$275,000.00
Summary
A Raman facility for advanced research supporting Australia’s natural gas, oil, coal and minerals industries. This modern Raman Spectroscopy facility will support the science and engineering that underpins the production and processing of Australia’s natural resources. Using high-pressure fibre optics, novel lasers and advanced imaging, the facility will enable the monitoring and improvement of processes and materials under extreme conditions.
Vapour phase detection of chemical warfare agents. This project aims to create luminescent plastic optoelectronic materials that can detect airborne chemical warfare agents, particularly nerve agents. Such agents are often odourless and invisible at lethal concentrations, so technology must detect and identify them before exposure. The intended outcomes are design rules for sensitive and selective materials that can be used in a handheld infield detector to sense chemical warfare agents based on ....Vapour phase detection of chemical warfare agents. This project aims to create luminescent plastic optoelectronic materials that can detect airborne chemical warfare agents, particularly nerve agents. Such agents are often odourless and invisible at lethal concentrations, so technology must detect and identify them before exposure. The intended outcomes are design rules for sensitive and selective materials that can be used in a handheld infield detector to sense chemical warfare agents based on the materials’ photophysical properties, and new analytical methods and sensing protocols. This research will be of interest to security agencies in Australia and internationally, and will better protect our military.Read moreRead less
The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which ....The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which sex genes are targets? Epigenetic enzymes are astonishingly conserved, providing exciting opportunities to draw from human systems to unravel novel signatures of temperature-induced sex switching in reptiles. This project will advance knowledge of developmental programming generally.Read moreRead less
Modern human origins and early behavioural complexity in Australia and Southeast Asia. This project tackles a fundamental issue in world prehistory: how and when did humans first cross from Southeast Asia into Australia. Three new archaeological excavations using novel methods of analysis will assess the nature of behavioural complexity and human evolution at the time when Australia was first colonised over 45,000 years ago.