Development And Evaluation Of Novel Anti-inflammatory Products Derived From An Indigenous Medicinal Plant
Funder
National Health and Medical Research Council
Funding Amount
$276,598.00
Summary
This collaborative project between researchers at the University of South Australia and Indigenous traditional owners from Northern Kaanju homelands (Cape York Peninsula, Qld) will develop and evaluate products derived from the Northern Kaanju medicinal plant Dodonaea polyandra. Extracts of the plant and novel compounds isolated from it have anti-inflammatory activity. These have the potential to be used in inflammatory diseases such as dermatitis, arthritis and inflammatory bowel disease.
Catalytic Degardation of Emerging Microplastic Pollutants. This project aims to develop robust and low-cost nanocarbon hybrids and advanced remediation technology to address globally emerging microplastic contaminations. The project expects to boost innovations in development of novel magnetic nanomaterials, process of microplastic purification, and green catalysis. Expected outcomes of this project will include efficient strategies in materials fabrication and a cutting-edge nanotechnology. The ....Catalytic Degardation of Emerging Microplastic Pollutants. This project aims to develop robust and low-cost nanocarbon hybrids and advanced remediation technology to address globally emerging microplastic contaminations. The project expects to boost innovations in development of novel magnetic nanomaterials, process of microplastic purification, and green catalysis. Expected outcomes of this project will include efficient strategies in materials fabrication and a cutting-edge nanotechnology. The success of the project will underpin the scientific bases of carbocatalysis, provide significant benefits to the Australian industry and society for a sustainable future with clean water, and increase the leading capacity of Australia in fundamental research and frontier technology.Read moreRead less
How Does Inflammation Of The Gut Change Its Sensory Innervation?
Funder
National Health and Medical Research Council
Funding Amount
$613,767.00
Summary
A large number of patients that are referred to gastroenterologists for pain and discomfort from the bowel are offered no effective treatment. This has a large impact on quality of life and often involves invasive tests to rule out inflammatory or cancerous causes. These patients are classified as suffering from irritable bowel syndrome (IBS). Patients who have diagnosable inflammatory bowel disease (IBD) where colonoscopy is positive may suffer similar symptoms but also have no treatment for th ....A large number of patients that are referred to gastroenterologists for pain and discomfort from the bowel are offered no effective treatment. This has a large impact on quality of life and often involves invasive tests to rule out inflammatory or cancerous causes. These patients are classified as suffering from irritable bowel syndrome (IBS). Patients who have diagnosable inflammatory bowel disease (IBD) where colonoscopy is positive may suffer similar symptoms but also have no treatment for this type of symptom. It is becoming apparent that a large subgroup of IBS patients have undergone prior infection or inflammation, and that there are in fact changes in the types of cells in biopsies from their gut. Thus there are common features to IBS and inflammation. These may provide a means for us to find new treatments for IBS and IBD symptoms. Mice develop similar microscopic changes in the colon after experimental inflammation to those seen in humans, so we can discover more from this model. We have recently established that there are several types of sensory nerve fibres from the mouse colon and rectum that convey information about contractions, distension and chemical mediators released from tissue to the central nervous system. These are almost certainly responsible for generating symptoms in patients. We aim in this project to discover how these sensory nerves change in their responsiveness to mechanical and chemical stimuli in experimental inflammation. Importantly we shall investigate the mediators that are present in the tissue which may activate sensory nerves and-or the receptors on sensory nerves that may be increased. These experiments we hope will provide a target at which to aim novel drug treatments for symptoms of IBS and IBD.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100253
Funder
Australian Research Council
Funding Amount
$450,948.00
Summary
Functional carbon hybrids for green catalysis and clean water. This project aims to develop a family of structure-tailored, robust and metal-free carbon hybrids and environmental-benign processes for catalytic degradation of emerging microcontaminants in water. Innovations are expected in the design of reaction-oriented nanocarbons, new concept in atomic level carbocatalysis from computation and in-situ characterisation, advanced purification technology, and breakthroughs in material engineering ....Functional carbon hybrids for green catalysis and clean water. This project aims to develop a family of structure-tailored, robust and metal-free carbon hybrids and environmental-benign processes for catalytic degradation of emerging microcontaminants in water. Innovations are expected in the design of reaction-oriented nanocarbons, new concept in atomic level carbocatalysis from computation and in-situ characterisation, advanced purification technology, and breakthroughs in material engineering. The anticipated outcomes will be the scientific basis for functional nanomaterials, nanotechnology, and green remediation technologies. Success will provide significant benefits in securing a sustainable future for Australia, with clean water and strategies for advanced manufacturing in related areas. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220101074
Funder
Australian Research Council
Funding Amount
$424,500.00
Summary
Conversion of biowastes to porous carbon materials for green catalysis. This project aims to develop a family of biowaste-derived porous carbon and single-atom-anchored porous carbon catalysts for the degradation of emerging microcontaminants in water. Innovations are expected in systematically developing affordable, facile, productive, and sustainable approaches. Via reaction-oriented structure design, new concept will be defined at the atomic level using calculations and in situ characterisati ....Conversion of biowastes to porous carbon materials for green catalysis. This project aims to develop a family of biowaste-derived porous carbon and single-atom-anchored porous carbon catalysts for the degradation of emerging microcontaminants in water. Innovations are expected in systematically developing affordable, facile, productive, and sustainable approaches. Via reaction-oriented structure design, new concept will be defined at the atomic level using calculations and in situ characterisations in material engineering and advanced purification technology. The anticipated outcomes will provide fundamental knowledge in green nanotechnologies for water remediation. Success will secure a sustainable future for Australia with clean water and strategies for advanced manufacturing in relevant areas.Read moreRead less
Testosterone Intervention For The Prevention Of Diabetes Mellitus In High Risk Men: A Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$5,054,654.00
Summary
Type 2 diabetes (T2DM) is increasingly common, costly and deadly. Some men at risk of T2DM have low testosterone (T) levels. Our preliminary data suggests that T treatment may prevent the development of T2DM, and improve cardiovascular and sexual function, body composition and bone density, and mood. This remains to be fully tested in a randomized placebo-controlled trial, and this project will do so in a 2-year study of T treatment compared to placebo in men at risk of T2DM participating in a l ....Type 2 diabetes (T2DM) is increasingly common, costly and deadly. Some men at risk of T2DM have low testosterone (T) levels. Our preliminary data suggests that T treatment may prevent the development of T2DM, and improve cardiovascular and sexual function, body composition and bone density, and mood. This remains to be fully tested in a randomized placebo-controlled trial, and this project will do so in a 2-year study of T treatment compared to placebo in men at risk of T2DM participating in a lifestyle program.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100208
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
An advanced computational facility based on a graphic processing unit for particulate research. The graphic processing unit (GPU) is becoming an engine for the next generation of supercomputers for scientific research. The technology at this new facility will be exploited to perform large-scale, real time simulations of complex particulate material processing which is critical to Australia’s mineral/metallurgical/material industries.
Controllable Synthesis of Defects in Catalysts for Electrocatalysis . This project aims to address the most critical issue of electrocatalysis: identification of active sites for carbon-based metal free catalysts (CMFCs). Through the development of new methodologies, this proposal will, for the first time, controllably synthesise the vacancy defects that are the major active sites for CMFCs. The expected outcomes from this project include in-depth understanding of the fundamentals of electrocata ....Controllable Synthesis of Defects in Catalysts for Electrocatalysis . This project aims to address the most critical issue of electrocatalysis: identification of active sites for carbon-based metal free catalysts (CMFCs). Through the development of new methodologies, this proposal will, for the first time, controllably synthesise the vacancy defects that are the major active sites for CMFCs. The expected outcomes from this project include in-depth understanding of the fundamentals of electrocatalysis: the reactivity of active sites and the catalytic performance with the number of active sites; which will not only significantly advance knowledge but also achieve breakthrough technologies that greatly benefit to the society and economy both for Australia and worldwide.Read moreRead less
Chronic inflammation underlies common and debilitating diseases and causes pain by unknown mechanisms. There is an urgent need to gain a deeper understanding of the mechanisms of chronic pain, which will allow the development of improved therapies with fewer side-effects. Our research program investigates the mechanisms of pain that are associated with inflammatory bowel disease and irritable bowel syndrome, with the goal of developing more effective and selective therapies.
Neuroimmune Interactions In Functional And Organic Gastrointestinal Diseases
Funder
National Health and Medical Research Council
Funding Amount
$419,180.00
Summary
Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD) are chronic, incurable diseases of the lower gastrointestinal tract with unknown causes and poor treatment options. Both the immune and nervous systems are altered in GI disease, but have traditionally been studied in isolation. My research investigates how the neuro-immune axis is altered in these diseases, using animal models and human tissue samples to identify novel treatment options for these debilitating diseases.