A Randomised Controlled Trial Of Prophylactic Hypothermia In Severe Traumatic Brain Injury.
Funder
National Health and Medical Research Council
Funding Amount
$2,061,506.00
Summary
Patients who suffer from a severe head injury (traumatic brain injury) have a 50% chance of having severe long term neurological disability or death. Some of this damage occurs after the initial injury and may be reduced by artificially lowering the body termperature for up to 7 days to protect the brain from further damage. This project will determine if early, sustained cooling is safe and if it can improve the long term neurological outcomes of patients with traumatic brain injury.
Understanding Tissue Responses To Fluid Resuscitation And Blood Transfusion During Ovine Sepsis To Improve Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$980,810.00
Summary
Annually, sepsis affects up to 30 million patients, killing more patients than the combined totals of breast, prostate and lung cancer. Fluid resuscitation is a cornerstone of sepsis therapy, aimed at improving oxygen delivery to key organs. Data now indicates that blood and non-blood fluids may worsen mortality. This study will investigate the mechanism of sepsis and the effect of blood and non-blood fluids, to provide data to clinicians which may reduce the vast global burden of this disease.
The Prophylactic Hypothermia To Lessen Traumatic Brain Injury-randomised Controlled Trial : Continuation Of Funding Request
Funder
National Health and Medical Research Council
Funding Amount
$266,321.00
Summary
Traumatic brain injury (TBI) is a major cause of death and long term disability. About half with severe TBI will die or have a poor outcome. The social and economic costs to the community are high. Treatment focuses on optimising oxygen and blood flow to the brain. Cooling may protect the brain. POLAR is a randomised trial of early cooling in patients with TBI. Cooling is started within 3 hours of injury. Data about the injury management and safety is collected. Recovery is measured at 6 months.