International Orthopaedic Multicenter Study In Fracture Care (INORMUS)
Funder
National Health and Medical Research Council
Funding Amount
$1,462,437.00
Summary
INORMUS is a global multi-centre prospective cohort study in 40,000 patients with musculoskeletal trauma (e.g. fractures or dislocations) to determine the incidence of major trauma complications (i.e. mortality, re-operations, and infections) and to examine a number of factors that may predict early complications. This study will allow us to address fundamental questions for the millions of adults worldwide who experience trauma annually and will have immense public health implications.
Improving The Measurement Of Non-fatal Injury Burden - Validating The Global Burden Of Disease (GBD) Project Through Synthesis And Analysis Of The Six Leading Injury Outcome Cohort Studies From Around The World
Funder
National Health and Medical Research Council
Funding Amount
$155,443.00
Summary
This project will use data from the six largest and most comprehensive cohort studies across five countries to evaluate methods for determining the disability associated with injury. The findings will direct how injury burden is measured for by the Global Burden of Disease (GBD) Study, and for individual country or region-specific studies. The research will have direct relevance to Australia by improving outcome measurement in ways that are critical for enhanced clinical, public health policy an ....This project will use data from the six largest and most comprehensive cohort studies across five countries to evaluate methods for determining the disability associated with injury. The findings will direct how injury burden is measured for by the Global Burden of Disease (GBD) Study, and for individual country or region-specific studies. The research will have direct relevance to Australia by improving outcome measurement in ways that are critical for enhanced clinical, public health policy and planning settings.Read moreRead less
Paediatric Validating Injury Burden Estimates Study (VIBES-Junior)
Funder
National Health and Medical Research Council
Funding Amount
$484,562.00
Summary
Injury is a leading cause of death and disability in children and adolescents, and can have lifelong effects for survivors. This study will quantify how well children recover from injury, and how long this takes, to establish better measures of the population impact of injury sustained in childhood and adolescence. The findings will be used to inform future health and social policy concerning primary prevention of injury in childhood and adolescence and the provision of services after injury.
An Individual-level Study Of Suicide Method Substitution Over Time
Funder
National Health and Medical Research Council
Funding Amount
$218,122.00
Summary
This study will explore patterns of suicide methods _ e.g., whether people who attempt suicide by hanging make subsequent attempts in the following month, and, if so, whether they use the same or different methods. It will track anonymised patients who have been hospitalised for a suicide attempt in 3 Australian states to determine the extent, method and outcome of any subsequent attempts. The study will inform questions about ïbest betsÍ in terms of restricting access to means of suicide.
Outcomes After Serious Injury: What Is The Recovery Trajectory And How Do The Priorities For Treatment And Disability Services Change Over Time?
Funder
National Health and Medical Research Council
Funding Amount
$766,630.00
Summary
Traumatic injury is a significant contributor to global disease burden, with serious injury commonly resulting in disability and profound costs to the individual, family and society. This population-based project will describe the long term consequences of injury and recovery experiences of more than 2500 seriously injured patients. This longitudinal study will use quantitative and qualitative data to provide a comprehensive overview of patient outcomes and experiences in the first 5-years after ....Traumatic injury is a significant contributor to global disease burden, with serious injury commonly resulting in disability and profound costs to the individual, family and society. This population-based project will describe the long term consequences of injury and recovery experiences of more than 2500 seriously injured patients. This longitudinal study will use quantitative and qualitative data to provide a comprehensive overview of patient outcomes and experiences in the first 5-years after injury.Read moreRead less
Understanding Causes Of The Rising Incidence Of Thyroid Cancer – What Can Mutations In The BRAF Oncogene Tell Us About Causes And Diagnostic Pathways For Thyroid Cancer?
Funder
National Health and Medical Research Council
Funding Amount
$610,222.00
Summary
The occurrence of thyroid cancer has increased rapidly over the last 25 years but the cause is unknown. The increase may reflect ‘over-diagnosis’ of less harmful cancers or greater exposure to causes of this cancer. Evidence suggests that a gene mutation (BRAF) in thyroid cancers is important in understanding the drivers of the increase. This study will examine the increase in thyroid cancer by investigating causes and diagnostic pathways considering the presence or absence of BRAF mutations.
The Epidemiology Of Multiple Myeloma In Australia (EMMA)
Funder
National Health and Medical Research Council
Funding Amount
$1,525,729.00
Summary
In Australia, over 1,000 people are diagnosed with multiple myeloma annually. Our proposal aims to identify possible environmental and genetic causes of this serious disease. People diagnosed with myeloma, and their family members, will provide detailed personal and family histories. We plan to investigate the role of sun exposure, body size and obesity, dietary factors and pesticides as well as a large range of genetic variants. The 5-year study will be conducted in Victoria and NSW.
Quantifying The Effectiveness Of Pertussis Vaccine In Older Adults
Funder
National Health and Medical Research Council
Funding Amount
$448,703.00
Summary
Pertussis is the most poorly controlled vaccine preventable disease in Australia. Childhood pertussis is a well-known public health problem but adult pertussis is also common and has a significant burden on the health system, especially in adults over 65 years. Pertussis vaccines for adults are currently not funded by our national immunisation program. This project will provide vital data to inform whether pertussis vaccination is cost-effective in older Australian adults.
A Population-based Family Study Of Follicular Lymphoma
Funder
National Health and Medical Research Council
Funding Amount
$1,703,070.00
Summary
Annually more than 900 Australians are diagnosed with follicular lymphoma. The proposed research aims identify the environmental and genetic causes of this serious blood cancer. People diagnosed with lymphoma, and a family member, will provide detailed personal and family histories, and a blood sample. Exposure to specific chemicals, types of work, sun exposure, and body size are some of the factors the study will examine. The 5-year study will be conducted in NSW, ACT and Victoria.
Collaborative Australian Renal Cell Carcinoma Epidemiology Study (CARES)
Funder
National Health and Medical Research Council
Funding Amount
$1,677,048.00
Summary
The objective of this project is to increase our knowledge of the causes of renal cell carcinoma, a relatively common, yet understudied, cancer and use this new knowledge to develop a risk prediction tool to provide a rational basis for risk counselling. The proposed project will establish a biobank and generate a research platform that, beyond the duration of the project, will allow us to identify diagnostic and prognostic biomarkers, and therapeutic targets.